Navigation Links
Nipping diabetes in the blood
Date:1/27/2014

An estimated 25.8 million Americans have diabetes. Another 79 million are thought to have "prediabetes," meaning they are at risk of developing type-2 diabetes.

Now Dr. Nataly Lerner of Tel Aviv University's Sackler Faculty of Medicine and her colleagues have discovered that a simple blood test reveals an individual's risk of developing type-2 diabetes before they develop either condition far earlier than previously believed. The findings, published in the European Journal of General Practice, could help doctors provide earlier diagnosis and treatment. Dr. Michal Shani and Prof. Shlomo Vinker of the Sackler Faculty of Medicine and Clalit Health Services collaborated on the study.

"Our study supports the idea that the A1c test, used to diagnose type-2 diabetes, can also be used at a much earlier stage to screen for the disease in the high risk population, like overweight patients," said Dr. Lerner.

Testing the test

In healthy people, glucose is absorbed from the blood for use by various tissues. But the cells of people with type-2 diabetes are resistant to insulin, which is produced by the pancreas and is central to regulating carbohydrate and fat metabolism in the body. These individuals have higher-than-normal blood glucose levels. People with prediabetes have blood glucose levels somewhere between normal and diabetic.

Blood glucose can be directly tested in several ways, but these tests only provide a snapshot. To get a picture of blood glucose levels over time, doctors test for levels of glycated hemoglobin, or A1c, in the blood. When blood glucose levels are high, more A1c is formed. So A1c serves as a biomarker, indicating average blood glucose levels over a two- to three-month period.

The A1c test has long been used to monitor type-2 diabetes. And in the past few years, the American Diabetes Association and World Health Organization have added the test to their guidelines as a criterion for diagnosing type-2 diabetes. According to the ADA, having an A1c level of 6.5 percent or more is an indicator of the disease and an A1c level of between 5.7 and 6.4 percent is an indicator of prediabetes. As a bonus, the test is simpler to administer than the most common blood glucose tests, requiring neither fasting nor consuming anything.

To evaluate the A1c test's ability to screen for diabetes in high-risk patients, the researchers analyzed the medical history of 10,201 patients who were given the test in central Israel between 2002 and 2005. They found that overall, 22.5 percent of the patients developed diabetes within five to eight years. Patients with A1c levels as low as 5.5 percent below the official threshold for diagnosing diabetes were significantly more likely to develop diabetes than patients with A1c levels below 5.5 percent. Every 0.5 percent increase in A1c levels up to 7 percent doubled the patients' risk of developing diabetes. Obesity also doubled patients' risk of developing diabetes, the researchers found.

Risk management

"We were actually able to quantify how risk increases with A1c levels," said Dr. Lerner. "This could allow doctors to make more informed decisions regarding diabetes prevention."

The study, one of the most comprehensive of its kind, provides compelling new evidence that the A1c test can accurately gauge risk at an earlier stage than is currently recognized. In combination with blood glucose tests and the identification of risk factors like family history, poor diet, lack of exercise, and obesity the test could help doctors provide earlier treatment. In some cases, lifestyle changes or medication could head off the disease, which is difficult or impossible to cure once developed.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Related medicine news :

1. How a cancer drug leads to diabetes
2. Heart failure patients with diabetes may benefit from higher glucose levels
3. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
4. Mouse Study Hints at New Path for Diabetes Treatment
5. Common Plastics Chemical Might Boost Diabetes Risk
6. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Cellular pathway linked to diabetes, heart disease
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
11. Xenotransplantation as a therapy for type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... ... Texas Physical Therapy Specialists (TexPTS) is pleased to announce the opening ... is the group’s 7th location in San Antonio and 23rd in Texas. Dr. ... from the clinic, which opened March 22, 2017. , The team of ...
(Date:3/24/2017)... Pittsburgh, PA (PRWEB) , ... March 24, 2017 ... ... the Oncology Nursing Society (ONS) wanted to create a communications platform that positions ... realize this goal, Elliance and ONS reinvented their online publication as an always-on, ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... ( http://www.hygieacare.com ) announced their partnership to prep patients for colonoscopy at the ... Endoscopy Centers in 87th Ave., Miami, FL. , The HyGIeaCare® Prep, ...
(Date:3/24/2017)... ... ... “Vintage and Harvest A Cultivation of Christian Love” is the creation of published author, ... his wife, Anna Marie. He and his wife are the proud parents of four ... of “Shadow and Substance.” , “Love, the agape kind, is seen as more than ...
(Date:3/23/2017)... ... 2017 , ... The physicians of KSF Orthopaedic Center PA are proud to ... location is located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 ... provide patients living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Today Stock-Callers.com have issued research reports on four ... NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. (NYSE: EW), ... companies are part of the Healthcare sector, which gave back ... , 2017, with the NYSE Health Care Index declining 0.2% ... the S&P 500 were down about 0.4% as a group. ...
(Date:3/24/2017)... 2017  GenomeDx Biosciences today announced that six abstracts ... Prostate Cancer Classifier tests will be presented at the ... Congress held March 24 to 28, 2017 in ... is Europe,s largest urological event ... urological field. The abstract titled "Muscle invasive ...
(Date:3/24/2017)...  HealthMine surveys with 9,250 insured consumers fielded from ... members want help from their plans in five key ... health, 2) help closing gaps in care, 3) better ... 5) relevant, real-time guidance. Meeting these needs is essential ... A Reason to Stay Engaged in ...
Breaking Medicine Technology: