Navigation Links
Ninety-one Percent of BARACLUDE(R) (entecavir) Treated Patients in a Four-Year Cohort Demonstrated Virologic Suppression to Undetectable Levels
Date:11/2/2007

nical program. Patients with HBV DNA levels of greater than or equal to 300 copies/mL at weeks 48, 96, 144, 192, or at the end of dosing were genotyped and a phenotype was determined for all novel emerging substitutions. All patients experiencing a virologic breakthrough (greater than or equal to 1 log(10) increase from nadir) were phenotyped even if they did not have emerging substitutions.

Study Results

-- At week 192 of BARACLUDE(R) (entecavir) treatment, 91 percent

(n=98/108) of nucleoside-naive chronic HBeAg-positive patients in this

cohort achieved undetectable viral load (HBV DNA <300 copies/mL) and 86

percent (n=96/112) of patients achieved ALT normalization (ALT less

than or equal to 1 times the upper limit of normal).

-- During years three and four, an additional 41 percent (n=39/96) of

patients lost HBeAg and 16 percent (n=15/96) of patients achieved HBeAg

seroconversion.

-- Resistance monitoring in this cohort identified one patient with

genotypic resistance to BARACLUDE who later experienced virologic

breakthrough.

-- Safety events were consistent with previous experience. Additional

cumulative safety results of patients reported in this four-year

cohort:

-- Ninety percent of patients had any adverse event.

-- Grade 3-4 adverse events were reported in 13 percent of

patients.

-- There were no discontinuations due to adverse events in this

cohort.

-- Less than one percent of patients experienced on-treatment ALT

flares during the fourth year.

About BARACLUDE(R) (entecavir)

Discovered at Bristol-Myers Squibb, BARACLUDE is a nucleoside analogue indicated for the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication with either evidence of persistent elevations in serum aminotransferas
'/>"/>

SOURCE Bristol-Myers Squibb Company
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6

Related medicine news :

1. Pharmacia may take 51.5 percent Abbott stake
2. 45 Percent Of Errors In Cancer Diagnosis Harm The Patient
3. Zyflamend inhibits 78 percent of prostate cancer cells
4. Births Out Of Wedlock Increased To 42 Percent in 2004 in the UK
5. Community Dentists To Receive 10 Percent Salary Boost
6. NHS Forced to Borrow Money at Rates of 10 percent
7. Almost 30 Percent Dentists Refuse To Sign NHS Contracts
8. Polyunsaturated Fats And Vitamin E Cut MND Risk By 60 Percent
9. More Than 50 Percent Indians Aged Over 40 Have Diabetes, High Blood Pressure
10. Around 20 Percent Take-Out Foods Are Unhygienic
11. 47 Percent Children Suffer from Malnutrition: Survey
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... 19, 2013 As warmer weather arrives ... Brookstone Lodge on some summertime packages. , “Whether guests ... looking for a fun staycation, we think that these ... and families. Asheville is so beautiful in the summertime ... several options that guests can choose from, based on ...
(Date:6/19/2013)... Scottsdale, AZ (PRWEB) June 19, 2013 Are ... could be losing clients to the competition. , Social ... sales at your massage practice. , Included in your ... into an effective tool in building awareness and revenue for ... now over 5.5 million Twitter users worldwide. Many of these ...
(Date:6/19/2013)... CCA , America's leader in ... to Vice President, Health Services, effective June 8, 2013. ... Services for CCA. He will replace the retiring ... privilege to lead CCA's dedicated team of health care ... society and our partners as we provide effective care ...
(Date:6/19/2013)... Chrysler made news recently when it refused ... million Jeeps. The Jeep models in question are the 1993-2004 ... to the NHTSA are vulnerable to fire and explosion in ... are rear-mounted and have been alleged to catch fire or ... Cherokee with 32 rear-end crashes, which resulted in 44 deaths ...
(Date:6/19/2013)... June 19, 2013 According to a June ... Weekend Sunburn,” it is not uncommon for a person to ... months. A person is likely to forget to reapply sunscreen ... is both dry and itchy. When this occurs, it is ... goo.gl/gDyjP). , “Most people do not realize that milk contains ...
Breaking Medicine News(10 mins):Health News:Fun Depot Partners with Brookstone Lodge on Summer Packages 2Health News:If Your Massage Practice Isn’t Tweeting, It Isn’t Generating New Sales: 3 Ways Twitter Helps Grow Massage Practices from Appointment-Plus 2Health News:CCA Names Dr. John Baxter Vice President, Health Services 2Health News:Zinda & Davis PLLC: Why the Chrysler Recall Refusal Matters And May Set a Dangerous Precedent 2Health News:Zinda & Davis PLLC: Why the Chrysler Recall Refusal Matters And May Set a Dangerous Precedent 3Health News:Skin Care – How to treat Sunburn 2
... News) -- Scientists have identified common genetic variations that may ... Vitamin E is an antioxidant found in a number of ... as peppers, tomatoes and pumpkins. Previous research has found that ... the vitamin in a person,s body. It,s been suspected that ...
... October, 2010 Elsevier / MC Strategies, a pioneer ... organizations, has partnered with the Association of periOperative Registered ... Nursing Skills: Perioperative Collection, the only perioperative-specific set of ... with the Standards and Recommended Practices. ...
... (SFMU) has chosen Springer to publish its scientific research ... mdecine d,urgence . Bruno Riou, Professor on the Pierre ... Universities is editor-in-chief of this official society journal. ... d,urgence is targeted at the community of French ...
... , WEDNESDAY, Oct. 20 (HealthDay News) -- In ... your adaptability and resilience, a new study suggests. Researchers ... national survey each year from 2001 to 2004. Those who ... than those exposed to high levels of adversity or no ...
... GOLDEN, Colo. (October 20, 2010) A new independent study ... patients at 5-star rated hospitals had a 72% lower risk ... an enormous gap that has held steady over the past ... the study, if all hospitals performed at the level of ...
... , TUESDAY, Oct. 19 (HealthDay News) -- Men with ... death from heart disease and all causes, a finding that ... for cardiovascular disease, according to new research. The study ... for about seven years. At the start of the study, ...
Cached Medicine News:Health News:Elsevier/MC Strategies and AORN launch perioperative nursing skills collection 2Health News:New ratings of American hospitals released with quality study by HealthGrades 2Health News:New ratings of American hospitals released with quality study by HealthGrades 3Health News:Low Testosterone May Raise Risk of Early Death: Study 2
(Date:6/19/2013)... , 19. Juni 2013 ... mit der Entwicklung von SCS microRESIST™, ... in der Beschichtung mit Parylene gelungen ... von biokompatiblem Parylene mit antimikrobiellen Eigenschaften ... schädlicher Mikroorganismen auf beschichteten medizinischen Geräten. ...
(Date:6/18/2013)... June 19, 2013 , ... disease (PD) patients as add-on to levodopa ... in motor symptoms in fluctuating PD patients as ... Newron Pharmaceuticals S.p.A. ("Newron"), a research and development ... and its partner Zambon S.p.A., a pharmaceutical company ...
(Date:6/18/2013)... , June 18, 2013  Intercept Pharmaceuticals, Inc.  (NASDAQ: ... focused on the development and commercialization of novel bile ... the pricing of an underwritten public offering of 1,730,000 ... price of $33.01 per share.  In addition, Intercept has ... to an additional 259,500 shares of common stock. ...
Breaking Medicine Technology:Specialty Coating Systems gibt die Einführung einer neuen antimikrobiellen Parylene-Technologie bekannt 2Safinamide Phase III Study Results Presented at 2013 MDS Meeting 2Safinamide Phase III Study Results Presented at 2013 MDS Meeting 3Safinamide Phase III Study Results Presented at 2013 MDS Meeting 4Safinamide Phase III Study Results Presented at 2013 MDS Meeting 5Safinamide Phase III Study Results Presented at 2013 MDS Meeting 6Intercept Pharmaceuticals Announces Pricing of Public Offering of Common Stock 2
... Havel,s Incorporated, the Cincinnati-based market leader in ... new echogenic ultrasound needle which could help reduce ... new echogenic needles using their new, innovative Micro ... surfaces to reflect sound waves back to the ...
... Inc., a global leader in temperature-controlled biomaterial storage, ... biotechnology and pharmaceutical industries, has announced the appointment ... chain. Based at the company,s U.S. ... activities for its sample relocation services, global logistics ...
Cached Medicine Technology:Havel's Incorporated Helping to Reduce Radiation Exposure with New EchoTuohy™ Ultrasound Needle 2BioStorage Technologies Appoints New Global Director of Supply Chain 2
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... With the Symphony family of Pacemakers, ... the market. Symphony, lighter than a passport, ... follow-up, using new technologies, and delivering powerful ... also indicated for dual-chamber and atrial tracking ...
With the Symphony family of Pacemakers, Ela presents the most advanced technology on the market. Symphony, lighter than a passport, will take your patients further, offering fast follow-up, using new...
Medicine Products: