Navigation Links
Nicotine exposure in pregnant rats puts offspring at risk for learning disabilities
Date:12/3/2010

BIRMINGHAM, Ala. Exposure to nicotine during pregnancy leads to a decrease in adult stem cells and a change in synaptic plasticity in the hippocampus of the offspring, according to new research from the University of Alabama at Birmingham presented at Neuroscience 2010, the annual Society for Neuroscience meeting in San Diego in November. Researchers say this could be a possible cause for behavioral problems such as attention-deficit hyperactivity disorder (ADHD) seen in children whose mothers smoked.

Adult stem cells in the hippocampus, the area of the brain most connected to learning and memory, continue to divide and produce new cells over a lifetime. The UAB team showed that exposing rats to nicotine during pregnancy leads to a decrease in the number of new cells in the hippocampus.

"Failure to correctly incorporate newborn cells into the circuitry of the hippocampus and the resulting disruption of neural pathways essential to learning could account for some of the behavioral problems observed later in the lives of children of mothers who smoke during pregnancy," said Robin Lester, Ph.D., associate professor in the Department of Neurobiology and primary investigator. "These problems could include various cognitive deficits, learning difficulties, ADHD and an increased predisposition to drugs of abuse."

The World Health Organization reports that approximately 20 percent of women continue to smoke during pregnancy. Lester says the findings indicate that the insult resulting from gestational nicotine exposure may be one cause for learning disabilities in children and could provide a brain-circuitry mechanism accounting for these behavioral problems.

"Nicotine, along with other addictive drugs such as cocaine and morphine, have been shown to have similar effects on newborn cells when given to older animals, but our new results with nicotine suggest that these effects are more dramatic in newborns and may indicate increased risk and/or susceptibility for damage to the learning processes during pregnancy," said Shay Hyman, a doctoral student in Lester's laboratory. "These studies should provide further reasons and/or warnings to expectant mothers that they should seek help in refraining from smoking during pregnancy."

Lester says that that it will be essential to repeat these findings under conditions that more accurately resemble human smoking behavior. This can be done by allowing rats to press a lever in order to deliver nicotine when they want, thereby effectively giving them free will to "smoke" rather than continuously exposing them to the drug.


'/>"/>

Contact: Bob Shepard
bshep@uab.edu
205-934-8934
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Nicotine replacement therapy is over-promoted since most ex-smokers quit unassisted
2. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
3. Nicotine Withdrawal Can Complicate Hospital Care
4. Kids Could Overdose From Nicotine-Laced Candy
5. Berkeley study shows ozone and nicotine a bad combination for asthma
6. Nicotine binding to receptor linked to breast cancer cell growth
7. Exposure to secondhand smoke among children in England has declined since 1996
8. Jion Beijing Great Wall International Travel Agency Immediate Exposure to China Expo 2010
9. Exposure to 9/11 Fumes Tied to Chronic Headaches
10. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
11. MSU researcher links potentially deadly infection, frequent cow exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2017)... ... July 23, 2017 , ... Scientists from the University of Exeter ... of high-intensity, weight-bearing activity equivalent to a medium-paced run for pre-menopausal women, or a ... who specializes in total spine care, I understand the importance exercise can play on ...
(Date:7/23/2017)... (PRWEB) , ... July 23, 2017 , ... ... has joined Florida Pain Relief Group – Melbourne, a practice owned by Physician ... certification in interventional pain management, Dr. Stern also is certified in pediatrics, emergency ...
(Date:7/22/2017)... ... July 22, 2017 , ... The arthroscopic ... repairs the opportunity to return to sports and jobs that require heavy physical ... Sports Medicine’s Annual Meeting in Toronto, Ontario, Canada. , “We studied ...
(Date:7/21/2017)... ... July 21, 2017 , ... Roderick Crabbe ... services to families and business owners in northern Florida, is joining the First ... support to area adults with developmental challenges. , The First Coast YMCA offers ...
(Date:7/21/2017)... ... July 21, 2017 , ... Hospital M&A activity slowed in the second ... of hospital acquisitions rose to 23 in the second quarter, up 15% from the ... the 20 announced deals in the year-ago second quarter. Only four of the transactions ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... , July 10, 2017  The tenth annual ... Boston, MA at the Sheraton Boston ... and unparalleled access to global decision makers and innovative ... 800+ life science leaders during two impactful days. BioPharm ... provides delegates with additional networking opportunities with 4,500+ life ...
(Date:7/5/2017)... July 5, 2017 Oramed Pharmaceuticals ... ), a clinical-stage pharmaceutical company focused on the ... has received approval from the Israel Securities Authority to dual-list ... Oramed common stock will commence trading on the TASE on ... current market capitalization of the Company, it is expected that ...
(Date:6/30/2017)... ROCKVILLE, Md. , June 30, 2017 ... that since the start of May, at least ten ... financings include private investments, public offerings and a loan ... $3.3 million to almost $80 million.  Kalorama Information provides ... customers of its Diagnostics Knowledge Center. ...
Breaking Medicine Technology: