Navigation Links
Nicotine binding to receptor linked to breast cancer cell growth
Date:8/23/2010

When nicotine binds to the nicotinic acetylcholine receptor (nAchR), it is known to promote smoking addiction and may also directly promote the development of breast cancer, according to a study published online August 23 in The Journal of the National Cancer Institute.

While smoking is a well-known risk factor for a broad range of cancer types, non-nicotine components of tobacco have generally been thought to be the carcinogens, so little is known about how nicotine acts on cells to promote cancer cell growth. For breast cancer in particular, some large epidemiological studies have suggested that smoking is related to increased breast cancer risk, but they have not been accompanied by molecular biology studies on how that actually works.

To determine whether nicotine works on the cellular level to promote breast cancer growth, Yuan-Soon Ho, Ph.D., of the Taipei Medical University, and colleagues, looked at 276 breast tumor samples from anonymous donors to the Taipei Medical University Hospital, to see whether subunits of the nicotinic acetylcholine receptor were overexpressed in breast cancer cells compared with surrounding normal cells.

The researchers found that human breast cancer cells consistently overexpressed the alpha 9 subunit of the nAChR (α9-nAchR), and that expression was higher in advanced-stage breast cancer compared with early-stage cancer. They also found that reducing the levels of α9-nAchRs inhibited tumor growth in laboratory experiments, whereas increasing the levels of α9-nAchRs or treating more normal breast cells with nicotine promoted the development of cancer characteristics.

The authors write: "These results imply that receptor-mediated carcinogenic signals play a decisive role in biological functions related to human breast cancer development."

The authors say their study was limited by its small sample size, and the fact that it included only Asian patients. Bre
'/>"/>

Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Berkeley study shows ozone and nicotine a bad combination for asthma
2. Kids Could Overdose From Nicotine-Laced Candy
3. Nicotine Withdrawal Can Complicate Hospital Care
4. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
5. Nicotine replacement therapy is over-promoted since most ex-smokers quit unassisted
6. CD74 serves as a survival receptor on colon epithelial cells
7. Androgen receptor may explain male dominance in liver cancer
8. Estrogen receptor status of HER2+ breast cancer correlates with response to anti-HER therapies
9. Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
10. New Guidelines Issued on Hormone Receptor Testing for Breast Cancer
11. Pharmacokinetic/Pharmacodynamic Data Support Further Development of Tobiras Next-Generation CCR5 Receptor Antagonist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Texas (PRWEB) April 17, 2015 From the ... years ago, the Texas non-profit organization has empowered young people ... its effort to bring fresh water and the Gospel ... with Liberty University. Between March 17 and 27, students, faculty ... provide 7,000 Liberians with fresh water and the Good News ...
(Date:4/17/2015)... Rapids, MI (PRWEB) April 17, 2015 Enthusiasts ... CRUSH Grand Rapids, Saturday, April 25, 2015. The event will ... Reserve Wine & Food (201 Monroe Ave NW, Grand Rapids, ... from around the West Michigan area. Patrons are encouraged to ... of elegance and fun. , This year’s event will feature ...
(Date:4/17/2015)... April 17, 2015 Testosterone treatment ... class of prescription medications increases the likelihood that ... or other life-threatening cardiovascular event continue to mount ... Court, Northern District of Illinois. According to an ... Panel on Multidistrict Litigation (JPML) on April 15th, ...
(Date:4/17/2015)... 2015 The American College of Traditional Chinese Medicine ... Day on April 29. The event will be held from 11 ... 555 DeHaro St. in San Francisco, CA. , The agenda for ... at the DeHaro campus (room F), 11:10 a.m. – Introduction ... – Light lunch with current students, faculty and staff, 1 p.m. ...
(Date:4/17/2015)... Carolina (PRWEB) April 17, 2015 With ... Dental Care has spent the last four years ... care, performing procedures ranging from general cleanings to dental ... a grand opening at their new office in North ... same services as their Concord office, including denture fittings, ...
Breaking Medicine News(10 mins):Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4Health News:American College of Traditional Chinese Medicine Hosts Open House 2
... , WASHINGTON, Nov. 24 New peer-reviewed data finding ... infected with chronic hepatitis C virus have received anti-viral therapy ... needs to move urgently on bipartisan legislation to support new ... Hepatitis Roundtable (NVHR) said today. , The ...
... study by researchers from Virginia Commonwealth University Medical Center ... fatty acids (PUFA) is associated with the progression of ... The study also found significantly higher plasma monounsaturated ... and NASH. Full findings appear in the December ...
... be on the hook for the high cost of drug advertising ... led by a University of British Columbia health policy researcher. ... Medicine , examined the US sales patterns of clopidogrel, a top-selling ... blood clots after heart attack or stroke. The drug was selected ...
... , American College of Medical Genetics ... National Family History Day, Thanksgiving 2009 , BETHESDA, Md., ... Family History Day, as declared by the U.S. Surgeon General. ... know their family medical history and if they haven,t already ...
... , HATBORO, Pa., Nov. 23 InfoLogix, Inc. ... enterprise mobility solutions for the healthcare and commercial industries, ... Managed Services at Siemens Health Services, has joined InfoLogix ... http://www.newscom.com/cgi-bin/prnh/20090618/NE35135LOGO ) , As Vice President of ...
... of arsenic compounds appears to cause oxidative DNA damage ... study published online November 23 in the Journal ... was once believed to detoxify inorganic arsenic, it is ... carcinogenicity. To assess the role of ...
Cached Medicine News:Health News:NVHR: New Data Finding Fewer than 1 in 5 Hepatitis C Patients Receiving Antiviral Therapy is 'Wake-Up Call' for Washington 2Health News:NVHR: New Data Finding Fewer than 1 in 5 Hepatitis C Patients Receiving Antiviral Therapy is 'Wake-Up Call' for Washington 3Health News:Metobolomics uncovers key indicators of nonalcoholic fatty liver disease 2Health News:Drug ads ineffective for boosting sales, could cost taxpayers: UBC-Harvard study 2Health News:'Family Health History and Genetics Privacy' is the Newest Addition to the ACMG Genetics & Your Health Video Series 2Health News:Jim Way, Former Vice President at Siemens Health Services, Joins InfoLogix, Inc. as Vice President of Strategic Healthcare Services 2Health News:Jim Way, Former Vice President at Siemens Health Services, Joins InfoLogix, Inc. as Vice President of Strategic Healthcare Services 3
(Date:4/17/2015)... N.J. and DETROIT , April ... five children live in poverty, the infant mortality rate is ... at 15 per 1,000 live births. Nearly 6 of 10 ... not receive adequate prenatal care.  These are sobering statistics that ... serving the people of Metro Detroit, is poised to change ...
(Date:4/17/2015)... April 17, 2015 Today, the Pharmaceutical ... employees from 12 biopharmaceutical companies as "We Work ... policy advocacy and community service. Established ... Awards were created by the biopharmaceutical industry to ... their careers, but have also shown an outstanding ...
(Date:4/17/2015)... 17, 2015 Sigma-Aldrich Corporation ... and High Technology company, today announced the opening ... headquarters and state-of-the-art Cell Culture Technical Center in ... will provide customized support to meet customer needs, ... "Our new Technical Center will significantly enhance ...
Breaking Medicine Technology:Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 2Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 3Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 4PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 2Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 3Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 4Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 5
... HUYA Bioscience International, a company at the ... strategic partnership with the School of Pharmaceutical Sciences at ... foothold in Southern China, aiming to accelerate the development ... The agreement provides HUYA with access to ...
... a pharmacy buying group advancing the growing buying power ... three-year prime vendor agreement with H. D. Smith, a ... with the programs and services available to our members ... the growth and identity of our organization," said Emmanuel ...
Cached Medicine Technology:HUYA Biosciences Establishes Strategic Partnership with Sun Yat-sen University's School of Pharmaceutical Sciences 2HUYA Biosciences Establishes Strategic Partnership with Sun Yat-sen University's School of Pharmaceutical Sciences 3Nigerian Association of Pharmacists and Pharmaceutical Scientists in America (NAPPSA) Announces Prime Vendor Agreement with H. D. Smith 2
Lacrimal Cannula, Curved - Open End, 21gSize: 21g x 1-1/2"....
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Medicine Products: