Navigation Links
Nicotine May Help Spur 'Prediabetes'
Date:6/11/2009

Toxin ups cortisol levels, encourages insulin resistance, study finds

THURSDAY, June 11 (HealthDay News) -- The nicotine in cigarette smoke may promote insulin resistance and lead to a condition known as prediabetes, new research shows.

The finding, to be outlined Thursday at the Endocrine Society's annual meeting in Washington, D.C., could explain why smokers are at higher risk for diabetes. The same team of researchers was able to partially reverse nicotine's effect on insulin in mice by giving the rodents the nicotine-blunting drug mecamylamine.

In a society news release, study author Dr. Theodore Friedman, chief of the division of endocrinology, metabolism and molecular medicine at Charles R. Drew University of Medicine and Science in Los Angeles, noted that smokers tend to face a higher diabetes risk, even though "smoking causes weight loss, which should protect against heart disease."

But prior studies have shown smokers to be more insulin-resistant, which leads to higher blood-sugar levels. Some studies had suggested that the key factor at work was nicotine's effect on the stress hormone cortisol, since, as Friedman said, "cortisol excess is known to induce insulin resistance."

In their study, the team gave adult mice twice-daily injections of nicotine for 14 days. The mice displayed higher levels of cortisol in the blood. They also ate less and lost weight compared to mice that did not receive the shots but nonetheless developed insulin resistance and prediabetes.

Treating the mice with the nicotine-agonist drug mecamylamine blocked this process somewhat, the researchers noted.

"Our results suggest that reducing tissue glucocorticoid levels or decreasing insulin resistance may reduce the heart disease seen in smokers," said Friedman. "We anticipate that in the future there will be drugs to specifically block the effect of nicotine on glucocorticoids [such as cortisol] and insulin resistance."

More information

There's more on prediabetes at the American Diabetes Association.



-- E.J. Mundell



SOURCE: The Endocrine Society, news release, June 11, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. AUDIO from Medialink and Commit Lozenge: Wanna Quit Smoking With Therapeutic Nicotine? Just Follow the Directions
2. Nicotine in breast milk disrupts infants sleep patterns
3. Nicotine in Breast Milk Shortens Babys Naptime
4. Initial reaction to nicotine can dictate addiction
5. Rat Study Gets at Root of Nicotine Addiction
6. Nicotine, Chili Peppers Offer Post-Surgery Pain Relief
7. Parkinsons Institute research shows that nicotine reduces levodopa-induced dyskinesias
8. Genes, brain chemistry may dictate nicotine cravings, says CU-Boulder study
9. Nicotine Plus Alcohol May Be Tough to Beat
10. Nicotine addiction slashed in test of new cigarette smoking strategy
11. Nicotine-Reduced Cigarettes Could Boost Quitting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nicotine May Help Spur 'Prediabetes'
(Date:2/22/2017)... ... February 22, 2017 , ... Apptricity® Corporation, ... (SCM) and spend management, today announced that Keppel Corporation has selected Apptricity Travel ... tracking. , “We are excited to announce the partnership between Keppel and ...
(Date:2/21/2017)... ... February 21, 2017 , ... Robins & Morton celebrated the ... on Feb. 21. , The celebration began with a ribbon cutting event at ... construction team and tribal leadership. , Choctaw Nation Durant Regional Medical Clinic ...
(Date:2/21/2017)... ... 2017 , ... Doctors on Liens has announced the addition of Mendonca ... to its growing network of doctors in Central and Northern California. Dr. Mendonca specializes ... as whiplash, back pain, neck pain, hip and knee pain, and headaches. Specializing ...
(Date:2/21/2017)... ... ... Ray Insurance Agencies, a Dallas area firm providing asset protection services and ... six month charity event aimed at raising local support and donations that will be ... deadliest diseases in America; more than 7.5 million people die from cancer related disorders ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... the further expansion of its eHealth App xChange™, providing clinical researchers more ... Bioclinica’s extensive and growing eHealth platform. Applications that enable patient-centered clinical trials ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Research and Markets has announced the addition ... Industry Forecast to 2025" report to their offering. ... The Global Apheresis Equipment Market ... the next decade to reach approximately $4.5 billion by 2025.  ... for all the given segments on global as well as regional ...
(Date:2/21/2017)... 21, 2017 Centurion Medical Products, a ... care, is making a major stride in emergency ... its IRIG-8™Wound Irrigation System . ... deliver copious volumes of irrigation solution to acute ... a significant improvement to the traditional syringe with ...
(Date:2/21/2017)... Research and Markets has announced the addition of the "EEG, ... to their offering. ... report provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , Latin America , and Rest ... through 2022. Also, a six-year historic analysis is provided for these markets. ...
Breaking Medicine Technology: