Navigation Links
Niacin-Statin Combo May Cause Side Effects for Heart Patients
Date:2/26/2013

TUESDAY, Feb. 26 (HealthDay News) -- Combining the vitamin niacin with a cholesterol-lowering statin drug appears to raise side effects in heart patients, a new study indicates.

Muscle, skin and gastrointestinal problems were among the side effects that caused one-quarter of patients to stop treatment in a study looking at whether the use of niacin in combination with a statin might reduce heart disease risk.

Niacin has long been used to boost levels of "good" HDL cholesterol and decrease levels of "bad" LDL cholesterol and triglycerides (fats) in the blood in people at risk for heart disease and stroke. However, niacin also causes a number of side effects, including flushing of the skin. A drug called laropiprant can reduce the incidence of flushing in people taking niacin.

This new study included nearly 26,000 patients with narrowing of the arteries. They received either 2 grams of extended-release niacin plus 40 milligrams of laropiprant or matching placebos. All of the patients also took the statin drug Zocor (simvastatin).

The patients from China, the United Kingdom and Scandinavia were followed for an average of almost four years. By the end of the study, 25 percent of patients taking niacin plus laropiprant had stopped their treatment, compared with 17 percent of the patients taking a placebo, according to the findings published online Feb. 26 in the European Heart Journal.

"The main reason for patients stopping the treatment was because of adverse side effects, such as itching, rashes, flushing, indigestion, diarrhea, diabetes and muscle problems," Jane Armitage, professor of clinical trials and epidemiology at the University of Oxford, said in a journal news release. "We found that patients allocated to the experimental treatment were four times more likely to stop for skin-related reasons, and twice as likely to stop because of gastrointestinal problems or diabetes-related problems."

Patients taking niacin and laropiprant had a more than a fourfold increased risk of muscle pain or weakness compared to the placebo group, the team noted.

Still, the final verdict on whether niacin is worth taking is yet to come, the researchers said.

"Although 25 percent of patients stopped the treatment early, 75 percent continued on it for approximately four years," Dr. Richard Haynes, clinical coordinator at Oxford's Clinical Trial Service Unit and Epidemiological Studies Unit, said in the news release. "Currently, we are analyzing the final data on the cardiovascular outcomes from the trial, and once we have these we will know whether or not the benefits of the treatment outweigh the [risks]."

One U.S. expert was less than impressed by niacin's performance.

The trial "confirms that, for the present moment, there may be little additional benefit with the use of niacin when patients are well treated with the lipid-lowering statin drugs," said Dr. Kevin Marzo, chief of cardiology at Winthrop-University Hospital in Mineola, N.Y.

He said that the results of the new trial, along with those from a prior large study, "now may put the final nail in the coffin on niacin-based strategies to raise HDL and lower cardiovascular events."

Other tried-and-true approaches may work best, Marzo added. "In addition to statins, our focus should be on continued lifestyle changes such as a Mediterranean diet, complemented with daily exercise," he said.

The full results on the study are expected to be presented at the annual meeting of the American College of Cardiology in March, and will be published in another paper.

More information

The U.S. National Institutes of Health outlines steps you can take to reduce heart risks.

-- Robert Preidt

SOURCES: Kevin Marzo, MD, chief of cardiology, Winthrop-University Hospital, Mineola, NY; European Heart Journal, news release, Feb. 26, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Acai Plus & Detox Plus Combo Pack Now Comes with Extra Information Guide with Every Purchase
2. Combo of Avastin, second drug shows promise fighting brain cancer, Mayo Clinic finds
3. New screening approach identified potential drug combos for difficult-to-treat melanomas
4. Combo Therapy May Help Ease Sleep Apnea at High Altitude
5. HIV Drug Combo May Help Prevent Malaria Reinfection
6. Being neurotic, and conscientious, a good combo for health
7. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
8. Cooking-Oil Combo May Improve Blood Pressure
9. Double drug combo could shut down abnormal blood vessel growth that feeds disease
10. Drug combo better for common type of metastatic breast cancer, UCI-led study finds
11. Booze, Energy Drinks, Casual Sex Combo Common in College: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Niacin-Statin Combo May Cause Side Effects for Heart Patients
(Date:7/26/2017)... ... July 26, 2017 , ... Isodiol International Inc. (CSE: ... specializing in the development of pharmaceutical and consumer products, announces the operational numbers ... 30, 2017. Iso International LLC recorded unaudited fiscal Q1 profits of $897,596 based ...
(Date:7/26/2017)... Springs, FL (PRWEB) , ... July 26, 2017 ... ... the nation’s leading innovative specialty pharmacies, has released an updated version of the ... the latest guidelines for treating chronic hepatitis C virus (HCV) infection. All of ...
(Date:7/25/2017)... ... July 25, 2017 , ... Summers in Palm Springs sizzle, but there are ... homemade gourmet ice cream, sparkling pools, and mile-high fun. , At Arrive's Ice Cream ... and other must-have knick knacks. Ice cream and sorbet flavors rotate, but the classics ...
(Date:7/25/2017)... ... July 25, 2017 , ... SureVest Insurance Group, a ... communities across North Carolina, is launching a charity event in conjunction with the ... the ongoing fight against bladder cancer. , The Bladder Cancer Advocacy Network (BCAN) ...
(Date:7/25/2017)... Irving, Texas (PRWEB) , ... July 25, 2017 ... ... and fastest growing ATM provider in the United States, today announced its partnership ... to financial institutions. , The foundation of the solution lies within Hyosung’s ...
Breaking Medicine News(10 mins):
(Date:7/19/2017)... 19, 2017  Mako Medical Laboratories partnered with Secretary ... Family Assistance Fund (MFA) to bring 140 soldiers back ... with their families one last time before being deployed. ... travel and logistics needed for these soldiers. "Mako Medical ... their families. We just wish we could bring them ...
(Date:7/13/2017)... , July 13, 2017  Centurion Medical Products, a leader ... DisImpactor ® fecal impaction removal device for hospice patient care. ... Centurion ... Patient pain management and emotional ... Hospice can help alleviate patient pain while preventing unneeded emergency department ...
(Date:7/11/2017)... Research Corp., also known as ,The Epigenetics Company, announced today the release ... manner using the myDNAge ™ test. Based on Horvath,s Clock, so ... and biostatistics at the David Geffen School of Medicine at UCLA ... DNAge ™ technology is used to analyze DNA methylation patterns of ... ...
Breaking Medicine Technology: