Navigation Links
Next-generation allergy vaccines to be developed in Finland to create effective and safe desensitization therapies
Date:10/21/2011

VTT holds patents on gene technology which can be applied to alter the structure of an allergen, i.e. a protein causing allergy, so that it will cause less allergic symptoms than the original allergen, while remaining effective in desensitisation therapy.

"The vaccine helps to improve the protection to the allergen, thus, alleviating the symptoms. That's why we prefer to use the term vaccine, instead of medication," VTT's Senior Advisor Hans Sderlund explains. The research objective is to develop an orally administered vaccine.

The foundation for this development rests on a scientific breakthrough dating back five years to a co-operation project involving VTT, the University of Eastern Finland and HUCH Skin and Allergy Hospital. Researchers were able to determine how an IgE antibody binds an allergen and were the first to present a detailed 3D structure of this complex. This proved to be different from what scientists around the world had anticipated.

Initially, Desentum Oy will develop a product line of 20 to 25 new hypoallergens which could be used as vaccines for some of the most important allergies. These include pollens (birch, hay, common wormwood, etc.), allergens from pets, and proteins associated with food allergies (fish, nuts, apple, celery). Clinical testing of the first products is anticipated to start within the next three years.

Pekka Mattila, Desentum Oy's Managing Director, knows how to run a biotechnology company and increase its business opportunities. He was one of the founding members of the Finnzymes Group and acted as its CEO until 2010, when the company was sold to the American Thermo Fisher Scientific.

What is an allergy?

Allergies are caused by the immune reaction to normally harmless proteins allergens - present in environment, food or consumer and medical products. Due to sensitisation, the body generates Immunoglobulin E (IgE) antibodies. Next time when these antibodies recognise the same allergen, they trigger an allergic reaction and cause symptoms in the respiratory or digestive system, or the skin. An extreme allergic reaction may cause anaphylaxis or even death.

The prevalence of allergies and allergic reactions has increased in the industrialised countries, and they are now estimated to belong to the top five most costly disease groups. In Europe, the number of people suffering from allergies is estimated to exceed 80 million, while in the US the corresponding number is 65 million. According to further estimates, half of the European population will suffer from an allergy by 2015.

In the US alone, the market for antiallergic drugs is anticipated to exceed USD 15 billion by 2015. In 2010, the estimated market for new allergy vaccines is approximately USD 700 million.


'/>"/>

Contact: Hans Soderlund Professor
Hans.soderlund@vtt.fi
358-207-225-104
VTT Technical Research Centre of Finland
Source:Eurekalert

Related medicine news :

1. In search of cancers common ground: A next-generation view
2. Next-generation hospital design can improve health -- and save money
3. Proteins in unroasted coffee beans may become next-generation insecticides
4. Viscira™ Earns Industry Praise for Next-Generation 3D Animation Production
5. Pharmacokinetic/Pharmacodynamic Data Support Further Development of Tobiras Next-Generation CCR5 Receptor Antagonist
6. Black Children May Be More Prone to Peanut Allergy, Study Finds
7. Switch to Powder-Free Latex Gloves Cuts Health Workers Allergy Risk
8. Longer Allergy Season Means More Misery
9. Using powder-free latex gloves reduces latex allergy rate in health care workers
10. Nut-allergy sufferers face prejudice -- new study
11. Prenatal pet exposure, delivery mode, race are key factors in early allergy risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Researchers at Moffitt ... ActiGraph’s CentrePoint Data Hub in a sample of participants enrolled in an ... and sleep monitoring solutions for the global scientific community. The company’s new CentrePoint ...
(Date:4/28/2017)... ... 28, 2017 , ... NuevaCare, a leading home care agency based in San ... Alto, is proud to announce information upgrades to its blog in the form of ... on topics such as home care (generally) as well as senior care and home ...
(Date:4/27/2017)... ... April 27, 2017 , ... ... hospital, based in Denver, Colorado, announced an agreement to create the Jane and ... support of the Jane and Leonard Korman Family Foundation. The collaboration leverages the ...
(Date:4/27/2017)... ... April 27, 2017 , ... The American ... 2017 Public Leadership in Neurology Award (PLINA). The couple joins a prestigious list ... Vice President Walter Mondale, actor Michael J. Fox and former U.S. Attorney General ...
(Date:4/27/2017)... ... April 27, 2017 , ... Offering the purest product of its ... times purer and more potent than the market has seen before. Swissx uses proprietary ... well as a patented chromatography process for extraction, to produce its CBD oil--maximizing its ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017 Global Surgical Drainage Device ... tubes used to remove excess liquid and air. The ... urine, bile or lymph. Surgical drains are used in ... as orthopedics surgery, cardiovascular surgery, neurosurgery, plastic surgery etc. ... to prevent accumulation of fluid e.g. blood or pus. ...
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/18/2017)... 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Uro/Gyn and Gynecology markets with innovative and proprietary products, ... March 31, 2017 after the market close on Tuesday, ... host a conference call and webcast to discuss its ... 2017 at 4:30 p.m. Eastern Time (3:30 p.m. Central ...
Breaking Medicine Technology: