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Newsbriefs from the July issue of the journal Chest
Date:7/4/2011

COMBINATION ANTITHROMBOTIC THERAPY MAY INCREASE BLEEDING RISK

A new study suggests that the use of combination antithrombotic therapy may increase the risk of clinically relevant bleeding in patients with atrial fibrillation (AF). Researchers from the United Kingdom, the Netherlands, and France compared outcomes in 3,728 patients with AF receiving anticoagulation alone and 848 patients with AF receiving combination antithrombotic therapy (anticoagulant and antiplatelet therapy). Results showed that patients receiving combination therapy had a 2.3-fold increased risk of clinically relevant bleeding compared with anticoagulation therapy alone. Combination antithrombotic therapy also does not appear to reduce the risk of stroke. Results suggest that combination antithrombotic treatment is justified only in patients where the benefit of adding antiplatelet therapy to anticoagulant therapy outweighs bleeding risk. This article is published in the July issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians: Chest. 2011;140(1):146-155.


IDENTIFYING PULMONARY ARTERIAL HYPERTENSION EARLY REMAINS PROBLEMATIC

One in five patients diagnosed with pulmonary arterial hypertension (PAH) in the United States report symptoms for more than 2 years before diagnosis. PAH is a progressive and fatal disorder, and the disease is often advanced when recognized, especially in younger patients. Researchers from Intermountain Medical Center, the University of California, University of Pennsylvania, Baylor College of Medicine, Boston University, and Mayo Clinic studied 2,967 adult patients enrolled in the Registry to Evaluate Early Long-term PAH Disease Management (REVEAL), for an 18-month period. In 21.1% of patients, symptoms were experienced for more than two years before PAH was recognized. History of obstructive airways disease and sleep apnea were independently associated with delayed PAH recognitio
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Contact: Jennifer Stawarz
jstawarz@chestnet.org
847-498-8306
American College of Chest Physicians
Source:Eurekalert

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