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News from the Latest Issue of Molecular Medicine Kicking The Habit - It's In The Genes
Date:6/29/2009

Scientists at the National Institute on Drug Abuse (VIDA) working in collaboration with colleagues at Vector Tobacco, Inc. and Duke University Medical School have identified genes that may help predict which people will have a better chance at kicking the tobacco habit.

Manhasset, NY (Vocus) June 29, 2009 -- Scientists at the National Institute on Drug Abuse (VIDA) working in collaboration with colleagues at Vector Tobacco, Inc. and Duke University Medical School have identified genes that may help predict which people will have a better chance at kicking the tobacco habit. NIDA's Tomas Drgon, PhD, and colleagues conducted a genome-wide association study that identified patterns that may determine quitting success rates. If replicated, genetic testing could be used to tailor smoking cessation programs to individuals.

In another study, a team of Swedish investigators examined insulin signaling in fat cells of lean individuals before, during and after a month-long high fat diet. During the study, the volunteers gained an average of 10 percent of their body weight and 19 percent total body fat. While they remained lean, they did develop moderate systemic insulin resistance. Insulin resistance has become an enormous public health problem that paves the way to type 2 diabetes and other medical conditions. It is the first study to measure the effects of a short-term high fat diet, and it shows that the assault of such a diet is already causing damage to the body's ability to regulate insulin. This study suggests a path for how diabetes may develop in otherwise healthy individuals and provides further evidence that a high-calorie, high-fat diet is a significant risk factor for type 2
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