Navigation Links
News from the Latest Issue of Molecular Medicine
Date:1/12/2010

New research from the bimonthly biomedical journal, Molecular Medicine. Molecular Medicine publishes research concerned with the pathogenesis of disease at the molecular level, in order to design specific molecular tools for disease diagnosis, treatment and prevention.

(Vocus) January 12, 2010 -- By the time a person experiences symptoms of an aggressive brain tumor it is often too late. Dr. Christina Piperi and her colleagues at the University of Athens Medical School have discovered genetic fingerprints of the glioblastoma multiforme brain tumor cell that could ultimately be used to diagnosis the tumor earlier in the disease process. They found that analyzing the methylation status helps differentiate normal and disease cells. Looking at four genes activated in glioma, they found that two of them – MGMT and RAR – were significantly more methylated in 58.8% to 70.58% of analyzed glioblastoma multiforme cases. This study also highlights a potential link between methylation patterns and a potent cytokine, IL-6, suggesting a specific role for inflammation mediators in the regulation of gene methylation. The hope is that the finding could offer clues to the aggressive nature of the tumor and point to new treatment avenues.

In another study, Stephanie L. Nott, Mesut Miyan and colleagues at the University of Rochester in upstate New York have discovered a potential treatment for endocrine resistant breast cancer tumors. It is well known that the estrogen hormone 17²-estradiol (E2), is involved in the initiation and progression of some types of breast cancer. Estrogen receptors have been used as transcription factors to mediate the effects of E2. That has been the basis for the state-of-the-art treatments for ER-positive breast cancer. But they do not work for ER-negative breast tumors. Dr. Nott and her colleagues tested the idea that they could design a transcription factor that regulates the estrogen responsive elements (EREs) of genes to stop the spread of ER-negative tumors. They used adenovirus infected ER-negative tumor cells derived from a breast adenocarcinoma. The monotransregulator repressed cell proliferation and infiltration and induced cell death by turning on genes required for the estrogen responsive elements to interact. “Specific regulation of genes bearing EREs could offer a therapeutic approach for de novo endocrine-resistant breast cancers,” the scientists said.

Enclosed is a table of contents for the latest issue. You can view all of the articles in the September-October issue by visiting the journal’s Web site at www.molmed.org.

Molecular Medicine is published by The Feinstein Institute for Molecular Research. The peer-reviewed journal strives to understand normal body functioning and disease pathogenesis at the molecular level, which may allow researchers and physician-scientists to use that knowledge in the design of specific molecular tools for disease diagnosis, treatment, prognosis, and prevention. The journal, a bimonthly publication, serves as a forum through which scientists and researchers can communicate recent discoveries to a multi-disciplinary, international audience interested in understanding and curing disease.

To listen to the latest podcast on these studies visit www.molmed.org/podcast.html.

###

Read the full story at http://www.prweb.com/releases/Molecular_Medicine/News/prweb3434554.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Fewer headaches on the horizon thanks to latest guidelines
2. URACs Latest Podcast Highlights Pro-Change Behavior Systems Lifestyle Management Program
3. Failure of Drug Importation Amendment in U.S. Senate is Latest Show of Industrys Controlling Hand in Health Reform Debate, According to Consumer Watchdog
4. GemaTech Launches Portable Recovery Unit. The Latest Design in Emergency Telecoms Resilience and Continuity
5. Latest epidemic? High cholesterol, obesity in fruit flies
6. Ovid Highlights the Latest Productivity Workflow Enhancements to Ovid Universal Search(TM) and its New Psychology Lexicon at Londons Online Information 2009 Conference
7. H1N1 News Today Examines the Swine Flu Virus From a Global Perspective; Read the Latest H1N1 Virus Vaccine & Prevention News From EIN News
8. ASAP Systems Releases Latest Version of their Passport Inventory and Asset Tracking Software with New Security Features and Administrative Tools
9. Lumension Provides Enhanced Endpoint Protection and Support for The Latest Windows Platforms
10. Leaders in the Study of Allosteric Modulation to Discuss Latest Research at Allosteric and Orthosteric Modulator Congress
11. Premier Plastic Surgery of Kansas Citys Extended Website Provides Latest Information on Male and Female Cosmetic Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
News from the Latest Issue of Molecular Medicine
(Date:5/26/2016)... ... May 26, 2016 , ... An April Gallup survey found rising ... 550 employees of Sun Health Senior Living (SHSL) may not share those ... doctor and prescription copays for the year, while holding the line on increasing their ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute ... a six-week smoking cessation class starting June 6 at their clinic in downtown Tampa. ... . , Additionally, the Lung Institute has created a free downloadable 4 Week ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... Top Doc! Along with his wonderful accolades and stellar patient reviews, Dr. Batelli ... Dr. Batelli! , Dr. Eugene Batelli is a highly trained Podiatric Surgeon who ...
(Date:5/26/2016)... ... May 26, 2016 , ... A health conscious snack that doesn't ... Bar, has ignited an undeniable buzz in the protein product community by offering ... any doughnut.  These doughnuts are packed with 11 grams of protein and made from ...
(Date:5/26/2016)... York, NY (PRWEB) , ... May 26, 2016 , ... ... have lips been so central to popular cosmetic improvement efforts. Record numbers of clients ... kissers appear more prominent or pouty, says Kally Papantoniou, MD, of Advanced Dermatology ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... beide primären Endpunkte und demonstriert ... in ‚ausgezeichneter plus guter , ...    ,      (Logo: http://photos.prnewswire.com/prnh/20130829/633895-a ... heute neue positive Daten von der MORA-Studie der ...
(Date:5/24/2016)... 2016 Celsion Corporation (NASDAQ: ... provided an update on its ongoing OVATION study, ... GEN-1, the Company,s DNA-based immunotherapy, with the standard ... with advanced ovarian cancer who will undergo neoadjuvant ... an IL-12 DNA plasmid vector formulated as a ...
(Date:5/24/2016)... May 24, 2016 Open Access ... Clinical Neurophysiology  Elsevier , a world-leading ... services, today announced the launch of Clinical ... journal that focuses on clinical practice issues in clinical ... clinical series, normal values and didactic reviews. It is ...
Breaking Medicine Technology: