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News briefs from the October issue of Chest
Date:10/6/2009

October issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.

LABAs/ICS COMBINATION THERAPY MAY DO MORE HARM THAN GOOD

Current guidelines recommend the use of inhaled corticosteroids (ICS) in combination with long-acting beta agonists (LABAs) to reduce the frequency of exacerbations in symptomatic patients with severe to very severe chronic obstructive pulmonary disease (COPD). However, new research shows that this combination therapy may not provide significant benefits for patients and may cause adverse events. Researchers from Spain, Chile, and Uruguay reviewed 18 randomized controlled trials with 12,446 participants where the primary outcomes were COPD exacerbations and mortality. The analysis showed that therapy with LABAs/ICS did not decrease severe exacerbation or all-cause or respiratory mortality; however, moderate exacerbations were significantly reduced. Furthermore, the combination therapy was associated with an increased risk of pneumonia. This article is published in the October issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.


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Contact: Jennifer Stawarz
jstawarz@chestnet.org
847-498-8306
American College of Chest Physicians
Source:Eurekalert

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