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News briefs from the January issue of Chest
Date:1/3/2011

DATA SHOWS OMALIZUMAB SAFE AND EFFECTIVE FOR MODERATE TO SEVERE ASTHMA

New research suggests that subcutaneous omalizumab is safe and effective an add-on treatment to corticosteroids for moderate to severe asthma in children and adults. Researchers from Uruguay, Argentina, and Chile performed a meta-analysis on eight trials where 1,883 patients received omalizumab and 1,546 received a placebo. At the end of the steroid reduction phase, patients taking omalizumab were more likely to have corticosteroids withdrawn completely compared with those taking placebo. Furthermore, patients taking omalizumab showed a decreased risk for asthma exacerbations at the end of stable and adjustable-steroid phase. The frequency of serious adverse events effects was similar between both groups, and there were no indications of increased risk of hypersensitivity reactions, cardiovascular effects, and malignant neoplasms. This article is published in the January issue of Chest, the peer-reviewed journal of the American College of Chest Physicians: Chest 2011; 139(1):28-35.

SIMULATION TRAINING LINKED TO DECREASED CATHETER INFECTION

New research shows that simulation-based training in sterile techniques during central vein catheterization (CVC) is associated with decreased rate of catheter-related bloodstream infection (CRBSI). Over 1 year, researchers from St. Luke's-Roosevelt Hospital Center in New York randomly assigned 47 second and third-year internal medicine residents to simulation-based training plus video training or video training alone, with a follow-up period to examine CRBSI 6 months later. During the follow-up period, a simulation-based training program in sterile techniques during CVC was implemented in the medical intensive care unit (MICU). Residents' scores in sterile techniques and CRBSI rates were compared with residents in the surgical intensive care unit (SICU) who did not receive simulation training. Baseli
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Contact: Jennifer Stawarz
jstawarz@chestnet.org
847-498-8306
American College of Chest Physicians
Source:Eurekalert

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