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News briefs from the January issue of Chest
Date:1/5/2010

pectively). Within the tiotropium group, the overall risk for serious or fatal lower respiratory events also was reduced. The mechanism by which tiotropium may reduce cardiovascular mortality is unclear, but researchers speculate that there may be an association with the reduction in respiratory events. The article is published in the January issue of Chest, the peer-reviewed journal of the American College of Chest Physicians.

IPRATROPIUM BROMIDE MAY INCREASE RISK FOR CARDIOVASCULAR EVENTS

Patients taking ipratropium bromide, an anticholinergic used in the treatment of COPD, may be at an increased risk for cardiovascular events (CVE), including heart failure. Researchers from the University of Washington in Seattle, WA, and Hines VA Hospital in Hines, IL, conducted a cohort study on 82,717 US veterans with a new diagnosis of COPD between 1999 and 2002. Of the patients, 44 percent were exposed to anticholinergics (mainly ipratropium) at some time during the study. Patients were followed until they had their first hospitalization for a CVE, until they died, or until September 30, 2004. Within the cohort, 6,234 CVE were identified (44 percent heart failure, 28 percent acute coronary syndrome, and 28 percent dysrhythmias). Results showed that any exposure to anticholinergics within the past 6 months was associated with an increased risk of CVE. However, among patients who received anticholinergics more than 6 months prior, an elevated risk of CVE was not seen. Researchers note that their findings are consistent with previous concerns raised about the cardiovascular safety of ipratropium bromide. This study is published in the January issue of Chest, the peer-reviewed journal of the American College of Chest Physicians.


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Contact: Jennifer Stawarz
jstawarz@chestnet.org
847-498-8306
American College of Chest Physicians
Source:Eurekalert

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