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News briefs from the January issue of Chest
Date:1/5/2010

SMALL, THIN CHILDREN MAY HAVE POORER LUNG FUNCTION

A new study shows that poor lung function during adolescence and through midlife may be influenced by several factors, including birth weight, height, and gender. Researchers from Newcastle University in the United Kingdom analyzed health data from 252 patients, all aged 14 years. Follow-up data also were obtained for 122 of the patients at age 49 to 51. Results showed that several factors were related to poorer lung function (as measured by FEV1) at age 14, including lower height, lower BMI, being breast-fed for less than 4 weeks, and childhood respiratory disease. Furthermore, several factors predicted a decline in lung function between the ages of 49 to 51 years, including more cigarettes smoked in the lifetime, having a higher FEV1 at age 14, and being female. Researchers note that women reach their maximum FEV1 at a younger age than men, which may explain why, after age 14, the lung function of women declines at a higher rate than the lung function of men. This article is published in the January issue of Chest, the peer-reviewed journal of the American College of Chest Physicians.

TIOTROPIUM ASSOCIATED WITH REDUCED MORTALITY

New research suggests that tiotropium, a long-acting anticholinergic used in patients with COPD, may be associated with a reduction in all-cause mortality, cardiovascular mortality, and cardiovascular events. Researchers from Caritas-St. Elizabeth Medical Center in Boston, MA, reviewed the outcomes of 30 completed clinical trials in the tiotropium project database. Within the trials, 10,846 patients were treated with tiotropium and 8,699 patients received a placebo. Results indicated that patients treated with tiotropium had lower incidence rates (IR) of all-cause mortality, cardiovascular mortality, and cardiovascular events (IR = 3.44, .91, and 2.15 per 100 patients, respectively), compared with placebo (IR = 4.10, 1.24, and 2.67, res
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Contact: Jennifer Stawarz
jstawarz@chestnet.org
847-498-8306
American College of Chest Physicians
Source:Eurekalert

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