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News briefs from the August issue of Chest
Date:8/5/2009

, MD, of McMaster University in Hamilton, ON, Canada, discusses the familiar debate about the safety of using long-acting β2-agonists (LABA) in monotherapy for asthma. The commentary focuses on data provided in the metaanalysis recently undertaken by the FDA of safety outcomes of 60,954 individuals in 110 LABA trials. Results of the analysis found that LABA used with mandatory inhaled corticosteroid (ICS) was not associated with an increased risk of asthma-related mortality, intubations, or exacerbations. Dr. Sears argues that an additional analysis beyond the FDA study is not practical or needed. In addition, he suggests that the use of LABA, when indicated, in mandatory combination with appropriate doses of ICS, should remain the standard treatment for patients with moderate to severe asthma. This article is published in the August issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.


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Contact: Jennifer Stawarz
jstawarz@chestnet.org
847-498-8306
American College of Chest Physicians
Source:Eurekalert

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