Navigation Links
News brief: SNPs in C-reactive protein are not associated with increased risk of cancer
Date:1/7/2010

Gene variants associated with increased circulating levels of C-reactive protein, a marker of inflammation, are not associated with an increased risk of cancer, according to a new brief communication published online January 7 in the Journal of the National Cancer Institute.

Stig E. Bojesen, M.D., Ph.D., of the Department of Clinical Biochemistry, Herlev Hospital, and Copenhagen University Hospital in Denmark, and colleagues used a Mendelian randomization design to test whether C-reactive protein (CRP) polymorphisms were associated with increased circulating plasma CRP levels and to determine whether this increase was associated with cancer. The study population included about 10,000 participants in a prospective study and about 36,000 in a cross-sectional study of the adult general population of Denmark, all of whom where genotyped for CRP single-nucleotide polymorphisms (SNPs).

The researchers found that variants in the CRP gene were associated with altered plasma levels of CRP but did not find an association between these gene variants and an increased risk of cancer. The authors write that "although we may be able to exclude CRP per se as a cause of cancer, we cannot exclude the possibility that inflammation could lead to cancer. Also, our results do not invalidate the potential clinical use of slightly increased plasma CRP levels to predict the risk of certain cancer subtypes."

In an accompanying editorial, Paolo Boffetta, M.D., of the International Prevention Research Institute, in Lyon, France, notes: "The study is an elegant example of how genetic variants that have a functional impact can be used to explore associations between environmental factors and disease, and specifically to identify and control for confounding factors, based on the approach that has become known as Mendelian randomization"


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. News brief: Knockdown of E2F1 reduces invasive potential of melanoma cells
2. News brief: Dermatologic infections in cancer patients treated with EGFRI therapy
3. News brief: Long-term testicular cancer survivors at high risk for neurological side effects
4. News brief: Estrogen receptor-alpha, breast cancer patients and tamoxifen response
5. News brief: Arsenic biomethylation required for oxidative DNA damage
6. News brief: Adverse symptom reporting by patients vs. clinicians
7. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
8. JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer
9. JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapy
10. JNCI news brief: Surgeon training found effective in breast cancer sentinel lymph node trial
11. JNCI news brief: High serum insulin levels and risk of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... ... The Boulevard is honored to host Shriners and Masons Children’s Day on ... the Main West Entrance of The Boulevard (in front of JCPenney). , The ... each child with a parent or guardian will be photographed for free and receive ...
(Date:3/23/2017)... ... March 23, 2017 , ... “My Journey Through Heaven”: the true-life ... infinitely more profound faith of God’s promise of Heaven for His people. “My Journey ... each day with his wife, three children and six grandchildren living and doing for ...
(Date:3/23/2017)... ... 23, 2017 , ... Vortex Biosciences, provider of circulating tumor ... circulating tumor cells using microfluidic western blotting” in Nature Communications on March 23rd. ... to capture CTCs and a microfluidic single-CTC resolution Western blot from ...
(Date:3/22/2017)... ... March 22, 2017 , ... Pinnacle 1 Insurance, which serves ... community enrichment program, has announced their latest charity partner. The new campaign fundraises ... critical needs of homeless families with children for thirty years. Compassionate community contributions ...
(Date:3/22/2017)... ... March 22, 2017 , ... In recognition of ... media enterprise focused on cancer patients, cancer centers and advocacy groups, and MJH ... educational video series, “No Ifs, Ands, or Butts,” that focuses on Colorectal Cancer ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... NEW YORK , March 22, 2017 ... ... cannabis market was worth an estimated $6.6 billion in 2016, and ... of 16% or reaching more than $24 billion by 2025. The ... 2025, or growing from $4.7 billion in 2016, to an estimated ...
(Date:3/22/2017)... 22, 2017 FinancialBuzz.com News Commentary ... rapidly due to the significant development and innovation in ... Market Research, the global electrophysiology market was worth $3.42 ... billion by 2022, with a GAGR of 13.4%. Electrophysiology ... diagnose abnormal heartbeats or arrhythmia. The report indicates that ...
(Date:3/22/2017)... MAPLE GROVE, Minn. , March 22, 2017   ... of Clomipramine Hydrochloride Capsules* USP, 25 mg, 50 mg and ... (clomipramine hydrochloride) Capsules USP. The clomipramine ... for the 12 months ending December 2016, according to IMS ... ...
Breaking Medicine Technology: