Navigation Links
News brief: Knockdown of E2F1 reduces invasive potential of melanoma cells
Date:12/23/2009

Inhibition of transcription factor E2F1 reduced epidermal growth factor receptor (EGFR) expression and reduced the invasive potential but not proliferation of metastatic melanoma cells, according to a brief communication published online December 23 in the Journal of the National Cancer Institute.

To investigate E2F1's role in cancer progression, Brigitte M. Ptzer, M.D., Ph.D., of the department of vectorology and experimental gene therapy at the University Rostock in Germany, and colleagues used E2F1 gene silencing in melanoma cells and in mice to compare cell growth and invasive potential and tumor growth and formation of metastatic lesions. The authors also examined expression of EGFR, a protein previously found to be associated with cancer progression, and effects of its inhibition.

Melanoma cells with reduced E2F1 expression had lower invasive potential even though they grew at the same rate as control cells. Tumors in animals with reduced E2F1 expression grew at similar rates, but formed fewer and metastatic lesions than control tumors. EGFR expression was decreased in E2F1-silenced cells, and its inhibition reduced the invasive potential of these cells.

"Because elevated expression of E2F1 and EGFR has been observed in other tumor types, the established mechanistic link may also be important in other human cancers," the authors write. "This association should be explored in future studies."

Study limitations: Because the study was based on specific in vitro and in vivo models, it is still unclear whether these mechanisms are useful targets in human cancer.


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. News brief: Dermatologic infections in cancer patients treated with EGFRI therapy
2. News brief: Long-term testicular cancer survivors at high risk for neurological side effects
3. News brief: Estrogen receptor-alpha, breast cancer patients and tamoxifen response
4. News brief: Arsenic biomethylation required for oxidative DNA damage
5. News brief: Adverse symptom reporting by patients vs. clinicians
6. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
7. JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer
8. JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapy
9. JNCI news brief: Surgeon training found effective in breast cancer sentinel lymph node trial
10. JNCI news brief: High serum insulin levels and risk of prostate cancer
11. JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... (NEW YORK, New York) , ... (PRWEB) May 05, 2016 , ... ... partnership with healthcare talent acquisition startup, HireNurses, on the eve of National Nurses ... for job seeking nurses and healthcare employers. With their enrollment into the Talent Tech ...
(Date:5/5/2016)... ... May 05, 2016 , ... Chronic stress can have a silent, ... can weaken the immune system and increase inflammation, both of which raise the risk ... adult congenital heart disease program at Harvard-affiliated Massachusetts General Hospital. Chronic stress also can ...
(Date:5/5/2016)... ... May 05, 2016 , ... T.E.N., a technology and ... May 3, at the 2016 ISE® Central Executive Forum and Awards Gala at ... Chief Security Officer of HMS, was selected as the Information Security Executive® of ...
(Date:5/5/2016)... NY (PRWEB) , ... May 05, 2016 , ... If ... or stretch marks on your skin, you may want to consider a treatment that ... MD, of Advanced Dermatology P.C. , Microneedling, also known as skin needling, ...
(Date:5/5/2016)... ... 2016 , ... Pigment Laser Tattoo Removal Center is proud to be the ... laser, the first 4-wavelenth picosecond laser to receive FDA Clearance. This new laser ... the market. Jeremy Miller, Tattoo Artist and former reality show contestant on Spike ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 Progra m ... trial of Oxitec , s mosquito ... Aedes aegypti by 96 %   ... a new plan to fight wild Aedes aegypti, the dangerous mosquito ... on the island of Grand Cayman .  MRCU, a global ...
(Date:5/5/2016)... , May 5, 2016  Diagnostic imaging ... decade due to concerns that these tests cause health ... approach to imaging, as well as the adoption ... era of medical peripherals that help health care providers cut ... Ampronix  advanced medical imaging is a renowned authorized reseller ...
(Date:5/5/2016)... , May 5, 2016 Research ... for PET Imaging in the USA"  report to their ... provides information on the current Positron Emission Tomography (PET) ... USA market. Along with the current known ... USA , the report also contains a ...
Breaking Medicine Technology: