Navigation Links
News brief: Estrogen receptor-alpha, breast cancer patients and tamoxifen response
Date:11/25/2009

Researchers have found evidence of a statistically significant survival benefit from adjuvant tamoxifen among patients whose estrogen receptor (ER)-positive tumors had high levels of phosphorylation of ER-alpha; at serine-118 (ER-alpha S118-P), according to a brief communication published online November 25 in the Journal of the National Cancer Institute.

Approximately 50% of breast carcinomas are resistant to tamoxifen. Preclinical studies have shown that ER-alpha S118-P is required for response to tamoxifen.

Gran Landberg, M.D., Ph.D., of the Breakthrough Breast Cancer Research Unit, School of Cancer, Enabling Sciences and Technology at the University of Manchester, and colleagues evaluated data from 239 premenopausal patients with breast cancer who participated in a randomized trial of 2 years of adjuvant tamoxifen treatment vs. no systemic treatment. The association between recurrence-free survival and ER-alpha S118-P expression in tumor tissue was investigated.

Researchers found evidence of a statistically significant recurrence-free survival benefit from adjuvant tamoxifen, compared with no systemic treatment, among patients whose tumors had high ER-alpha S118-P expression (23.7 vs. 72.2 recurrences per 1000 person-years) but not among patients whose tumors had low expression (51.0 vs. 57.0 recurrences per 1000 person-years). ER-alpha S118-P was not associated with a benefit among untreated patients.

"Our study highlights the importance of assessing the functionality of a drug target," the authors write. "Future studies are necessary to evaluate whether ER-alpha S118-P expression is associated with tamoxifen response among post-menopausal patients."


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. In brief: New prognostic indicator for patients with IPF
2. JNCI news brief: Improving the biomarker pipeline for early cancer detection
3. JNCI news brief: Hepatitis B virus mutations may predict risk of liver cancer
4. JNCI news brief: Breast cancer hormone receptor status and risk of a second primary tumor
5. JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab
6. JNCI news brief: High serum insulin levels and risk of prostate cancer
7. JNCI news brief: Surgeon training found effective in breast cancer sentinel lymph node trial
8. JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapy
9. JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer
10. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
11. News brief: Arsenic biomethylation required for oxidative DNA damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 Evolutions Medical & Day Spa ... Santa Barbara News-Press Readers’ Choice 2014 poll. This is ... poll as Best Medical Spa. The 2014 Readers’ Choice ... about Evolutions Medical Spa recognition: , “Not only does ... as a top-notch, cutting-edge medical spa as well. Founder ...
(Date:8/29/2014)... 2014 Sansego is an ... interactive online community, and a range of personalized coaching ... the way to professional athletes. Crowie has brought together ... with him throughout the majority of his triathlon career. ... the triathlon public. , Sansego provides the following:, ...
(Date:8/29/2014)... 2014 September yoga month was created ... yoga and its health benefits. To support this Ekhart ... their "Yoga Month Challenge" , This 4 week guided ... and experienced yogis practice yoga regularly from their own ... Challenge ' is suitable for all levels, and the ...
(Date:8/29/2014)... New Delhi (PRWEB) August 29, 2014 ... a new service named ‘Remove Bad Reviews’. This service ... tough time on account of negative reviews against them. ... should not fail to deliver the committed results to ... serious study about the world of internet marketing. , ...
(Date:8/29/2014)... Senior Independence has promoted Mica Rees ... Rees has been with Senior Independence since March 2013 ... wholly owned subsidiary of Ohio Presbyterian Retirement Services ... including personalized home health care (e.g., physical therapy), hospice ... adult day centers. , Rees will continue to move ...
Breaking Medicine News(10 mins):Health News:Evolutions Named Best Medical Spa in Santa Barbara by Santa Barbara News Press 2Health News:Evolutions Named Best Medical Spa in Santa Barbara by Santa Barbara News Press 3Health News:5 x World Champion Triathlete, Craig “Crowie” Alexander, Launches Online Triathlon Coaching Company – Sansego 2Health News:5 x World Champion Triathlete, Craig “Crowie” Alexander, Launches Online Triathlon Coaching Company – Sansego 3Health News:Ekhart Yoga Launches the Yoga Month Challenge 2Health News:ReputationChief.Com Announces a New Service ‘Remove Bad Reviews’ 2Health News:Senior Independence Promotes Rees to Vice President of Operations & Business Development 2
... American Chemical Society,s (ACS) award-winning " Global Challenges/Chemistry Solutions ... machines seem to be a major source of so-called ... than the head of a pin -- that researchers ... the podcast, Mark Anthony Browne, Ph.D., explains that the ...
... Ill. -- The American Society for Gastrointestinal Endoscopy (ASGE) ... program specifically dedicated to promoting quality in endoscopy, in ... States. The ASGE Endoscopy Unit Recognition Program honors endoscopy ... assurance, endoscope reprocessing and CDC infection control guidelines. To ...
... research hopes to explain premature births and failed inductions of ... Bristol suggests a new mechanism by which the level of ... The researchers, Dr Claire Hudson and Professor Andrs Lpez ... Heesom in the University Proteomics Facility and the School of ...
... Reporter , TUESDAY, Dec. 20 (HealthDay News) -- Sleep problems ... health issues and poorer performance on the job, a new ... from the United States and Canada online or in person ... disorder. The most common problem, suffered by one-third of ...
... use of total hip arthroplasty (THA) and total knee arthroplasty ... postoperative treatment. Aquatic therapy has been shown to have ... after surgery, after the wound has healed. According to ... Medicine and Rehabilitation , beginning aquatic therapy just 6 days ...
... , TUESDAY, Dec. 20 (HealthDay News) -- ... screening to protect all college athletes from sudden death ... a college football player died from complications due to ... mandatory screening of all Division I student athletes. ...
Cached Medicine News:Health News:ASGE recognizes 27 endoscopy units for quality and safety 2Health News:ASGE recognizes 27 endoscopy units for quality and safety 3Health News:Balancing the womb 2Health News:Many Police Officers Battle Sleep Woes, Study Finds 2Health News:Many Police Officers Battle Sleep Woes, Study Finds 3Health News:Aquatic therapy soon after total knee arthroplasty improves outcomes 2Health News:Screening Alone Not Enough to Prevent Sudden Death in College Athletes 2
(Date:8/29/2014)... 2014 According to the ... Services (Equipment, Reagent, Primer, Probe, Custom Oligos), End-User ... Gene Synthesis, NGS, DNA, RNAi) - Global Forecast ... Synthesis Market is expected to reach $1,712.1 Million ... at a CAGR of 9.8% from 2014 to ...
(Date:8/29/2014)... WASHINGTON , Aug. 29, 2014 Diseases ... a generation ago are returning. Measles was declared ... cases in 2014 as of August 15—the highest incidence ... public health department declared whooping cough a problem ... children are getting sick and dying from these preventable ...
(Date:8/29/2014)...  Unilife Corporation ("Unilife" or "Company") (NASDAQ: ... to release its financial results for the fiscal 2014 ... market trading ends on Tuesday, September 9, 2014. ... 4:30 p.m. U.S. EDT on Tuesday, September 9, 2014 ... the Company,s financial results, commercial partnerships, and future outlook.  ...
Breaking Medicine Technology:Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2
... Continues Biocatalysis Business Growth With a Further $4m R&D Investment -- CRAIGAVON, Northern Ireland, October 7, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
... N.J., Oct. 7 Novartis Pharmaceuticals Corporation today ... Gilenya™ (fingolimod) 0.5 mg daily, a first-line oral ... was approved by the US Food and Drug ... For people with MS and healthcare professionals seeking ...
Cached Medicine Technology:Almac Continues Biocatalysis Business Growth With a Further $4m R&D Investment 2Almac Continues Biocatalysis Business Growth With a Further $4m R&D Investment 3Almac Continues Biocatalysis Business Growth With a Further $4m R&D Investment 4Almac Continues Biocatalysis Business Growth With a Further $4m R&D Investment 5Almac Continues Biocatalysis Business Growth With a Further $4m R&D Investment 6Almac Continues Biocatalysis Business Growth With a Further $4m R&D Investment 7Novartis Committed to Supporting Patients and Healthcare Professionals with Education Programs and Support Services that Enhance Access to Gilenya 2Novartis Committed to Supporting Patients and Healthcare Professionals with Education Programs and Support Services that Enhance Access to Gilenya 3Novartis Committed to Supporting Patients and Healthcare Professionals with Education Programs and Support Services that Enhance Access to Gilenya 4Novartis Committed to Supporting Patients and Healthcare Professionals with Education Programs and Support Services that Enhance Access to Gilenya 5Novartis Committed to Supporting Patients and Healthcare Professionals with Education Programs and Support Services that Enhance Access to Gilenya 6Novartis Committed to Supporting Patients and Healthcare Professionals with Education Programs and Support Services that Enhance Access to Gilenya 7
... SPECIFICATIONS Appearance/Form: White to buff-colored powder Activity: >=590g of ... (A&B): Passes tests Limit of Methanol: Specific Rotation ... pH (4%, H 2 O): 3.5 to 5.5 Loss ... C 1 : 25-50% C 2 + C ...
Gentamicin is a selection antibiotic used for selection of a Bac-to-Bac recombinant expression bacmid following transposition. Gentamicin is provided as a solution at a concentration of 50 mg/ml....
Gentamicin is an aminoglycosidic antibiotic that inhibits bacterial growth by inhibiting protein synthesis. Gentamicin is used for prevention and elimination of bacterial contaminants in cell culture...
1.0% Tryptone, 0.5% yeast extract, 0.5% Sodium Chloride, 0.6% agarose....
Medicine Products: