Navigation Links
News brief: Estrogen receptor-alpha, breast cancer patients and tamoxifen response
Date:11/25/2009

Researchers have found evidence of a statistically significant survival benefit from adjuvant tamoxifen among patients whose estrogen receptor (ER)-positive tumors had high levels of phosphorylation of ER-alpha; at serine-118 (ER-alpha S118-P), according to a brief communication published online November 25 in the Journal of the National Cancer Institute.

Approximately 50% of breast carcinomas are resistant to tamoxifen. Preclinical studies have shown that ER-alpha S118-P is required for response to tamoxifen.

Gran Landberg, M.D., Ph.D., of the Breakthrough Breast Cancer Research Unit, School of Cancer, Enabling Sciences and Technology at the University of Manchester, and colleagues evaluated data from 239 premenopausal patients with breast cancer who participated in a randomized trial of 2 years of adjuvant tamoxifen treatment vs. no systemic treatment. The association between recurrence-free survival and ER-alpha S118-P expression in tumor tissue was investigated.

Researchers found evidence of a statistically significant recurrence-free survival benefit from adjuvant tamoxifen, compared with no systemic treatment, among patients whose tumors had high ER-alpha S118-P expression (23.7 vs. 72.2 recurrences per 1000 person-years) but not among patients whose tumors had low expression (51.0 vs. 57.0 recurrences per 1000 person-years). ER-alpha S118-P was not associated with a benefit among untreated patients.

"Our study highlights the importance of assessing the functionality of a drug target," the authors write. "Future studies are necessary to evaluate whether ER-alpha S118-P expression is associated with tamoxifen response among post-menopausal patients."


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. In brief: New prognostic indicator for patients with IPF
2. JNCI news brief: Improving the biomarker pipeline for early cancer detection
3. JNCI news brief: Hepatitis B virus mutations may predict risk of liver cancer
4. JNCI news brief: Breast cancer hormone receptor status and risk of a second primary tumor
5. JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab
6. JNCI news brief: High serum insulin levels and risk of prostate cancer
7. JNCI news brief: Surgeon training found effective in breast cancer sentinel lymph node trial
8. JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapy
9. JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer
10. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
11. News brief: Arsenic biomethylation required for oxidative DNA damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2017)... ... January 15, 2017 , ... Going above ... program that strives to better communities around the world by offering the Gensuite ... provides the opportunity for team members to become involved in a cause that ...
(Date:1/15/2017)... ... January 15, 2017 , ... San Francisco Magazine ... Bay Area counties for 2017. Almost 1,000 nominations were submitted and a little ... process. Results were announced the magazine’s January 2017 issue . , Under ...
(Date:1/14/2017)... ... January 14, 2017 , ... Healthy ... expanding line of activated charcoal products. With more and more people opting to ... products according to how they cater to specific needs. , Moody Zook focused ...
(Date:1/13/2017)... ... January 13, 2017 , ... People ... levels. Counting carbohydrates is as easy as checking the nutrition label on foods ... blood sugar levels. Despite being sugar-free, proteins can influence — either positively or ...
(Date:1/13/2017)... ... , ... With the increasing public preference for chemical-free personal ... alternatives for customers who have grown more conscious about maintaining their health and ... charcoal products, Moody Zook Chief Executive Officer Nate Ginsburg explained their company’s decision ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... YORK , Jan. 16, 2017 ... Densitometers Market Outlook to 2022", provides key market data ... provides value, in millions of US dollars, volume (in ... Dual Energy X-Ray Absorptiometry (DEXA) and Quantitative Ultrasound (QUS). ... shares data for each of these market segements, and ...
(Date:1/16/2017)... 16, 2017  Verathon ® Inc., a leading manufacturer and ... new GlideScope ® Spectrum TM Single-Use video laryngoscopes. ... and Ambient Light Reduction TM technology, which actively optimizes ... ... Introducing another bright idea ...
(Date:1/16/2017)... , Jan. 16, 2017 When synthetic Fentanyl ... market their product as top-rate. They offered free samples, inviting ... customer service. Soon, business was booming. ... described as 100 times more powerful than morphine, has racked ... in last 2 years. One dealer,s recorded fentanyl sales ...
Breaking Medicine Technology: