Navigation Links
News brief: Arsenic biomethylation required for oxidative DNA damage
Date:11/23/2009

Biomethylation of arsenic compounds appears to cause oxidative DNA damage and to increase their carcinogenicity, according to a new study published online November 23 in the Journal of the National Cancer Institute.

Although biomethylation was once believed to detoxify inorganic arsenic, it is now thought to enhance its toxicity and potentially its carcinogenicity.

To assess the role of arsenic biomethylation in oxidative DNA damage in mice, Michael P. Waalkes, Ph.D., of the National Cancer Institute at the National Institute of Environmental Health Sciences, and colleagues compared oxidative DNA damage in methylation-competent cell lines vs. methylation-deficient cell lines exposed to arsenic.

Exposure of the methylation-competent cells, but not methylation-deficient cells, was followed by a sharp rise in oxidative DNA damage. Subsequent to the peak of oxidative DNA damage, methylation-competent cells, more rapidly than methylation-deficient cells, acquired the in vitro characteristics of cancer cells.

Animals have been engineered not to biomethylate arsenic. "Although inorganic arsenicals have not yet been tested for carcinogenic effects in these genetically altered mice, this clearly should be a high priority," the authors write.

In an accompanying editorial, Michael F. Hughes, Ph.D., of the Environmental Protection Agency, in Research Triangle Park, N.C., reviews the history of research concerning arsenic methylation and its role in carcinogenesis. He notes that future investigations will need to determine whether arsenic-induced oxidative stress contributes to arsenicinduced toxicity and carcinogenesis by affecting cell signaling pathways and/or apoptosis.


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. News brief: Adverse symptom reporting by patients vs. clinicians
2. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
3. JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer
4. JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapy
5. JNCI news brief: Surgeon training found effective in breast cancer sentinel lymph node trial
6. JNCI news brief: High serum insulin levels and risk of prostate cancer
7. JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab
8. JNCI news brief: Breast cancer hormone receptor status and risk of a second primary tumor
9. JNCI news brief: Hepatitis B virus mutations may predict risk of liver cancer
10. JNCI news brief: Improving the biomarker pipeline for early cancer detection
11. In brief: New prognostic indicator for patients with IPF
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... More than 2000 styles of newly designed prom ... online store carrying celebrity inspired special occasion dresses. With ... perfect dresses for their prom. For those who are ... TheCelebrityDresses.com would be an ideal choice. , "We ... inspired by the most loved styles seen at this ...
(Date:4/18/2015)... Aureus Medical Group (web: aureusmedical.com), ... therapy jobs, has announced that it will participate ... Therapy Association Annual Conference to be held May ... SC. , The SCAPTA Annual Conference offers ... and services. , Representatives from Aureus Medical’s ...
(Date:4/18/2015)... PHOENIX, ARIZONA – In March, Mark Ona, ... secure destruction professionals across the United States, earned the ... now display “CSDS” as a professional title with his ... Association of Information Destruction 2015 Annual Conference began - ... the 20 people who took the exam, Ona was ...
(Date:4/17/2015)... Bradley, Illinois (PRWEB) April 18, 2015 ... community, will begin its Supportive Living Week Celebration on ... focus on having a healthy mind, body and soul. ... Marshall in McLeansboro, Illinois, serves older adults of all ... to maintain their independence. , Supportive Living Week is ...
(Date:4/17/2015)... 2015 Rosetta Radiology is proud to ... their list of diagnostic imaging services. This solidifies them ... the Upper East Side of Manhattan. , The new ... The addition of PET-CT, combined with Rosetta’s state of ... to work with patients through several stages of the ...
Breaking Medicine News(10 mins):Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3
... , , EL SEGUNDO, Calif., ... ), the only national organization creating hope in a comprehensive ... cure is mourning the loss of legendary actor Patrick Swayze. His ... subsequent battle put a spotlight on pancreatic cancer, the fourth leading ...
... , , ... , CHARLESTON, S.C., Sept. 14 According to ... without a prescription, despite efforts to control antibiotic-resistant bacteria as a ... Using a keyword search of "purchase antibiotics without a prescription" ...
... Sept. 14 HealthSouth Corporation (NYSE: HLS ) announced ... dividend of $16.25 per share on its 6.5% Series A Convertible ... record on Oct. 1, 2009. , , ... of inpatient rehabilitative healthcare services. Operating in 26 states across the ...
... officials say , MONDAY, Sept. 14 (HealthDay News) -- With ... officials on Monday urged small businesses to prepare now to ... , "We need to make sure that operations and businesses ... Janet Napolitano, U.S. Secretary of Homeland Security, said during an ...
... up chances of other cancers, clots , MONDAY, Sept. ... high risk for developing breast cancer do reduce their ... a new analysis suggests. , That was the conclusion ... randomized clinical trials and a head-to-head assessment of the ...
... , HOPKINTON, Mass., Sept. ... the world leader in information infrastructure solutions, today announced ... with more than 25,000 healthcare provider customers, has consolidated ... RSA and VMware solutions. As a result, eClinicalWorks ...
Cached Medicine News:Health News:The Pancreatic Cancer Action Network Is Saddened by the Death of Actor Patrick Swayze 2Health News:MUSC Researchers Concerned About Online Drug Availability 2Health News:Small Businesses Urged to Prepare for Swine Flu 2Health News:Medications That Lower Breast Cancer Risk Carry Other Dangers 2Health News:Medications That Lower Breast Cancer Risk Carry Other Dangers 3Health News:eClinicalWorks Utilizes EMC to Manage Business Expansion and Reduce Costs 2Health News:eClinicalWorks Utilizes EMC to Manage Business Expansion and Reduce Costs 3
(Date:4/17/2015)... HILL, N.C. , April 17, 2015 /PRNewswire/ ... the creation of many new forms of provider ... Accountable Care Organizations (ACOs). The rapid evolution of ... to adapt their access, pricing and service delivery ... networks. To help the pharma sector ...
(Date:4/17/2015)... , April 17, 2015 Inivata, ... company announced today that their presence at the 2015 American ... a presentation by co-founder Nitzan Rosenfeld and a ... attending April 18 th - 22 nd . ... plasma using ctDNA , forms part of a ...
(Date:4/17/2015)... , Apr. 17, 2015 Research and Markets ... the "ADME-Toxicology Testing - Global Strategic Business Report" ... analyzes the worldwide markets for ADME-Toxicology Testing in US$ ... In-Vitro), and ADME Testing. The report provides ... , Japan , ...
Breaking Medicine Technology:Pharmaceutical Industry Struggling to Better Serve Provider Networks Such as Accountable Care Organizations (ACOs) 2Inivata Co-founder Nitzan Rosenfeld to Present at AACR Annual Meeting 2ADME-Toxicology Testing (In-Vivo, & In-Vitro) Market - Global Strategic Business Report 2015: Pharma Industry Renews Focus on Cost Optimization 2
... The American Association of,Health Freedom and the ... at the Baromedical Research,Institute and Louisiana State ... the successful treatment of chronic traumatic brain ... (2007 Oct 12;1174:120-9),are purportedly the first-ever demonstration ...
... Statement and National HIV/AIDS Elimination Act, NEW YORK, ... role of,advancing prophetic social justice ministry, Black clergy are ... for theologically,sound HIV/AIDS public policy. Working with the National ... live up to the biblical,mandate that calls us to ...
Cached Medicine Technology:Researchers Report First Successful Treatment of Chronic Traumatic Brain Injury 2Statement From The National Conclave on HIV/AIDS Policy for Black Clergy 2Statement From The National Conclave on HIV/AIDS Policy for Black Clergy 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: