Navigation Links
News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
Date:2/17/2010

Expression of aldehyde dehydrogenase (ALDH) in pancreatic adenocarcinoma is associated with worse overall survival in patients who have undergone resection for early-stage disease, according to a new study published online February 17 in the Journal of the National Cancer Institute.

ALDH activity characterizes normal stem cells and cancer stem cells (CSCs) in several human malignancies, including pancreatic adenocarcinoma; however, the clinical significance of ALDH-expressing cancer stem cells is unclear.

William Matsui, M.D., of the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, in Baltimore, and colleagues analyzed ALHD expression by immunohistochemisty in 269 primary surgical specimens of pancreatic adenocarcinoma and its association with survival. Reverse transcription polymerase chain reaction and in vitro cell invasion assays were used to examine mesenchymal features (the ability to differentiate into a variety of cell types) and the invasive potential of ADLH-positive pancreatic cancer cells relative to the bulk cell population.

ALDH-positive tumor cells were detected in 90 of the 269 primary surgical specimens, and their presence was associated with worse survival (median survival for patients with ALDH-positive tumors was 14 months vs 18 months for patients with ALDH-negative tumors). ALDH-positive cells were approximately five- to 11-fold more likely to proliferate in vitro and in vivo compared with unsorted or ALHD-negative cells. These cells also expressed genes consistent with a mesenchymal state and had in vitro migratory and invasive potentials that were threefold greater than those of unsorted cells.

"These results provide evidence for the clinical relevance of CSCs in pancreatic adenocarcinoma and may explain how the detection of these cells in primary tumors may result in shortened overall survival," the authors write.


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. In brief: New prognostic indicator for patients with IPF
2. JNCI news brief: Improving the biomarker pipeline for early cancer detection
3. JNCI news brief: Hepatitis B virus mutations may predict risk of liver cancer
4. JNCI news brief: Breast cancer hormone receptor status and risk of a second primary tumor
5. JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab
6. JNCI news brief: High serum insulin levels and risk of prostate cancer
7. JNCI news brief: Surgeon training found effective in breast cancer sentinel lymph node trial
8. JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapy
9. JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer
10. News brief: Contrast agent with MRI improves detection of lymph nodes metastases
11. News brief: Childhood survivors of CNS cancers and leukemia have lowered educational attainment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... ... Hearing” campaign, advocating for active, healthy lifestyles and highlighting the importance of proactive ... with hearing impairments and shares the latest innovations in hearing aid technology. ...
(Date:8/18/2017)... ... , ... The Dawn Johnson Insurance Group, a Missouri-based insurance and financial planning ... support for efforts to educate the local population on cancer realities while attracting donations ... , Each day in America, roughly 4,600 new cases of cancer are diagnosed ...
(Date:8/18/2017)... , ... August 18, 2017 , ... ... services and asset protection assistance to communities in North-Central West Virginia, is embarking ... services to at-risk boys in the area. , The Chestnut Mountain Ranch (CMR) ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... planning assistance that serves communities throughout southern Florida, is working to support the ... assets to children from low income families. , The Take Stock In Children ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... planning firm that serves residential and commercial clients in the greater Houston region, ... raise community support for the fight against cancer. , Founded by Tony and ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... Aug. 3, 2017  Opioid addiction and other drugs ... healthcare costs and threatening outcomes, were problems taken on ... IVD industry that support them, met this week. This ... said that drugs of abuse, procalcitonin and acute kidney ... the organization,s 69th meeting in San Diego, ...
(Date:8/2/2017)... CaryRx, a next-generation full-service pharmacy, has announced the launch of ... Washington D.C. metropolitan area. CaryRx aims ... medications through the convenience of its patient-friendly mobile app. Prescriptions ... hour to any location in D.C. ... to Washington D.C. ," says Areo Nazari ...
(Date:7/31/2017)... July 31, 2017 7D Surgical, developer of ground ... purchased the 7D Surgical System to support its strategic sales ... D.C. and Virginia.  7D Surgical has entered into ... of the premier medical facilities within those markets. ... ...
Breaking Medicine Technology: