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News Tips from the Journal of Neuroscience
Date:11/13/2007

tain encephalitogenic peptides linked to the outer two domains of restricting MHC class II molecules. This week, Sinha et al. constructed a new one, RTL551, from the outer domains of the I-Ab class II molecule and an encephalitogenic peptide derived from myelin oligodendrocyte protein (MOG-35-55). RTL551 reduced the severity of active and passive MOG-induced EAE in mice. For passively transferred EAE, the authors introduced green fluorescent protein labeled, MOG-35-55-reactive T-cells. The transferred cells preferentially expressed the pathogenic cytokine IL-17 and tumor necrosis factor α(TNFα), which were downregulated by RTL551. RTL551 also reduced the infiltration of inflammatory cells into the spinal cord of mice with passive EAE.


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Contact: Sara Harris
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Society for Neuroscience
Source:Eurekalert

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