Navigation Links
Newly identified stem cells may hold clues to colon cancer
Date:3/29/2012

nts showing that Lrig1, a molecule that regulates ErbB activity, is present in intestinal cells that have the qualities of stem cells (self-renewal, and the ability to produce all the cells of the intestine).

"Essentially, what we show is that the Lrig1-expressing cells are stem cells and they are largely quiescent," Powell said. "We also show that they're distinct from the Lgr5-expressing stem cells that had become a sort of 'hallmark' stem cell populationwith different gene expression profiles and different proliferative status."

They also showed that Lrig1 is not only a marker of intestinal stem cells, but also acts as a tumor suppressor and inhibits the growth and proliferative signals of the ErbB family acting as a sort of "brake" on cell proliferation that can lead to cancer.

Postdoctoral fellow Yang Wang, Ph.D., eliminated Lrig1 in mice and showed that nearly all of those mice developed intestinal tumors, providing further evidence suggesting that Lrig1 functions as a tumor suppressor.

The findings underscore the importance of ErbB signaling in the behavior of intestinal stem cells from which colorectal cancer may arise.

Most exciting, said Coffey, is that the mouse model his lab has generated as a part of these studies is one of the only mouse models to develop tumors in section of the intestines where most human tumors develop: the colon. One additional advantage of this model, in contrast to others, is that the tumors develop quickly and can be easily monitored with endoscopy, which will make it easier to assess how therapeutic interventions are working.

"We are fairly confident that this will be the 'go-to' model to study colon cancer in mice for the foreseeable future," Coffey said.


'/>"/>

Contact: Melissa Marino
melissa.marino@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Beat The Odds and Get Back on Track; Revitalizing Fitness Training and Exercise Resolutions With Newly Released, Complimentary Video Series
2. Gene discovered for newly recognized disease in Amish children
3. Newly identified proteins critical to FA pathway DNA repair function
4. Khanna Institute to Offer Newly FDA Approved Expanded Range of Intacs for Keratoconus
5. ProbioticSmart.com Re-Launches Newly Expanded Online Store for Human, Pet, and Livestock Health Products and Supplements
6. Newly Relaunched Autoinsurance.net Offers Consumers Smart Tips To Consider When Purchasing Car Insurance
7. Unique and Nutritious Vegetarian Recipes Featured in Newly Released Hand-Bag Friendly “A must have...The Maroema Cook Book”
8. Caregivers Find Hearing Loss Newly Relaunched Website a Welcome Help
9. Altered brain development found in children with newly diagnosed epilepsy
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 28, 2015 , ... Joining a growing ... Hospital recently transitioned management companies to partner with Wound Care Advantage (WCA) to ... wound center. , Transitioning wound care management providers can be a complex ...
(Date:8/28/2015)... IL (PRWEB) , ... August 28, 2015 , ... With ... benefit concert returned for the second year to the Adams County Fairgrounds in Mendon, ... was held to raise money to support music education in the underfunded school districts ...
(Date:8/28/2015)... ... , ... On May 30th, 2015, Best Drug Rehabilitation, a results-based substance abuse ... Mission” benefit concert in Mendon, IL. Held in the Show Barn at the Adams ... education programs in the underfunded local school districts of Mendon at neighboring Quincy, IL. ...
(Date:8/28/2015)... Boynton Beach, FL. (PRWEB) , ... August 28, ... ... creating problems for businesses nationwide. Addictions specialist, Dr. James Strawbridge, gives a new ... Strawbridge believes that it should begin with the employer and employees getting together ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... a low cost. Personalized with practice contact information and logos, Calendars stand alone ... can also incorporate Calendars into seasonal mailings, thank you and welcome communications, and ...
Breaking Medicine News(10 mins):Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2Health News:SmartPractice® Introduces 2016 Calendars for Dental Practice Giveaways 2
... the profile for the usage of long-acting contraceptive methods. ... award, shows, amongst other things, that 10% of women ... "Long-acting contraceptives (the IUD, contraceptive injection or contraceptive ... at the Hospital del Mar in Barcelona and author ...
... eyestrain, poor posture, study finds , WEDNESDAY, Oct. 28 ... reduce the level of pain linked to poor posture ... just assume that problems will be solved by purchasing ... It,s also important to make sure the furniture is ...
... A clinical trial for ... Oak, and will open soon at the University of Michigan Comprehensive Cancer Center in Ann Arbor, ... ... women with an aggressive form of metastatic breast cancer is now open at Beaumont Hospital, ...
... ... supplement delivers enhanced speed, growth and productivity while replacing undefined media components such as ... ... 2009 -- InVitria presented the successful performance of its newest CHO cell culture ...
... 28 Two-time Major League Baseball (MLB) Manager ... featured on this month,s episode of Sharing Miracles - ... compelling and inspirational stories of real patients. Sharing Miracles ... stations nationwide. , An iconic figure in baseball, Torre ...
... Minn., Oct. 28 NeuroVasx, Inc., a medical device ... and ischemic stroke, announced today that the first procedure ... performed in Madrid. cPAX received CE Mark earlier this ... Endovascular and Percutaneous Treatment, Clinica Nuestra Senora del Rosario, ...
Cached Medicine News:Health News:The IUD is the most popular long-acting contraceptive amongst Europeans 2Health News:Takes a Pro to Make Offices Pain-Free 2Health News:Beaumont, U-M Open Study of Drug for Advanced Breast Cancer 2Health News:Beaumont, U-M Open Study of Drug for Advanced Breast Cancer 3Health News:Beaumont, U-M Open Study of Drug for Advanced Breast Cancer 4Health News:InVitria Reports Successful Cell Culture Performance of Zap-CHO, a Defined and Cost Effective CHO Cell Culture Media Supplement 2Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 2Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 3Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 4Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 5Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 6Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 7Health News:NeuroVasx Announces First Case of cPAX Aneurysm Treatment System in Spain 2Health News:NeuroVasx Announces First Case of cPAX Aneurysm Treatment System in Spain 3
(Date:8/27/2015)... 27, 2015  Now that Intuitive Surgical, Inc.® has ... surgical robot, hospitals with robotic surgery programs need to ... to see where they stand with robotic surgery. Are ... Have they adopted best practices for safety? Should they ... future? ECRI Institute, which has nearly 50 ...
(Date:8/27/2015)... , Aug. 27, 2015   ... Pharmacy Provider (IOPP™) is expanding its population ... a medication-focused transition of care program for ... "RxCare Management," provides hospitals with technology systems ... performance measures that have been mandated by ...
(Date:8/27/2015)... LAKEWOOD, Ohio , Aug. 27, 2015  A ... according to Booz Allen Hamilton . A ... that product development inefficiencies are impeding and disrupting manufacturers, ... Can Cut Waste and Improve Value In Product Development ... cost of inaccessible data and how it affects the ...
Breaking Medicine Technology:ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 2ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 3Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2New White Paper Reveals How Manufacturers Can Improve Product Development Processes 2
... , Feb. 17 New research ... Parkinson,s disease, according to a study released today that will be presented ... Toronto April 10 to April 17, 2010 . , ... the beginning of the research.  Participants were asked about their use of ...
... Italy , Feb. 17 The results of ... EVEREST (European Vertebroplasty Research Team) Centers (Dr. G.C. Anselmetti-Candiolo Torino, ... S. Masala-Roma , Dr. M. Muto-Napoli ,) confirms the ... that the procedure provides significant and sustained pain relief. , ...
Cached Medicine Technology:An Ibuprofen a Day Could Keep Parkinson's Disease Away 2Multi-Center Data in a Large Series of Patients Show Vertebroplasty Provides Dramatic and Lasting Pain Relief for Vertebral Compression Fractures 2Multi-Center Data in a Large Series of Patients Show Vertebroplasty Provides Dramatic and Lasting Pain Relief for Vertebral Compression Fractures 3Multi-Center Data in a Large Series of Patients Show Vertebroplasty Provides Dramatic and Lasting Pain Relief for Vertebral Compression Fractures 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: