Navigation Links
Newly identified cell population key to immune response

Scientists from the Walter and Eliza Hall Institute have identified the key immune cell population responsible for regulating the body's immune response.

The finding could have wide-ranging repercussions for the treatment of autoimmune diseases, organ transplantation and cancer, and change how the efficacy of newly developed drugs is measured.

The discovery was made by Dr Erika Cretney, Dr Axel Kallies and Dr Stephen Nutt from the institute's Molecular Immunology division. It centred on a population of immune cells called regulatory T cells.

Regulatory T cells (T-regs) are responsible for limiting the immune response. Disorders that decrease T-reg activity can lead to autoimmune disorders such as type 1 diabetes or coeliac disease, while increased T-reg activity can suppress the immune system when it should be actively killing cancerous or infected cells.

Dr Kallies said the research team had used molecular signatures to identify which cells within the regulatory T cell population were responsible for suppressing immune responses.

"It turns out that the bulk of cells which are classified as regulatory T cells may not do much," Dr Kallies said. "In this study we have identified a distinct group of effector regulatory T cells, or 'active T-regs', which are the key drivers of immune response regulation."

Dr Nutt said the research had implications for clinical trial outcomes.

"Researchers often measure regulatory T cell numbers in clinical trials as a parameter for establishing whether there has been a positive immune response," Dr Nutt said. "We have shown that the absolute number of regulatory T cells isn't as important as the presence of this particular active regulatory T cell population."

Dr Nutt said the research showed that mice without active T-reg cell populations developed severe autoimmune inflammatory bowel disease, which is fatal.

"Not having this T cell population in the gut causes the immune response to go into overdrive and attack the body's own cells," he said. "A lack of the factor that is needed to generate active T-reg cells has also been implicated in human genome-wide studies of Crohn's disease. So it would seem that this cell population is strongly linked to the development of autoimmunity."

Dr Cretney said that re-defining the active subset of the T-reg population would give researchers the ability to develop new ways to increase or block their activity in the body. "The next step for my research is to look at the function of this active T-reg population in autoimmunity and in cancer."

Dr Kallies said that for these reasons, there was a lot of excitement in the medical community about regulatory T cells. "Clinicians have shown that regulatory T cell activity impacts on many therapies," he said. "Many research teams are trying to manipulate and expand these cells for therapeutic use. Our finding will transform the way that researchers look at immune responses and open new avenues for treating diseases such as autoimmunity and cancer."


Contact: Penny Fannin
Walter and Eliza Hall Institute

Related medicine news :

1. Beat The Odds and Get Back on Track; Revitalizing Fitness Training and Exercise Resolutions With Newly Released, Complimentary Video Series
2. Gene discovered for newly recognized disease in Amish children
3. Newly identified proteins critical to FA pathway DNA repair function
4. Khanna Institute to Offer Newly FDA Approved Expanded Range of Intacs for Keratoconus
5. Re-Launches Newly Expanded Online Store for Human, Pet, and Livestock Health Products and Supplements
6. Newly Relaunched Offers Consumers Smart Tips To Consider When Purchasing Car Insurance
7. Unique and Nutritious Vegetarian Recipes Featured in Newly Released Hand-Bag Friendly “A must have...The Maroema Cook Book”
8. Caregivers Find Hearing Loss Newly Relaunched Website a Welcome Help
9. Altered brain development found in children with newly diagnosed epilepsy
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements.
Post Your Comments:
Related Image:
Newly identified cell population key to immune response
(Date:11/29/2015)... ... ... Key Housing, a top-rated corporate housing service for the San Jose and ... In showcasing this featured apartment community in San Jose, Key Housing is helping those ... find housing suitable to their needs by showcasing quality housing. , “San Jose many ...
(Date:11/28/2015)... ... ... November 30th at 6:00 a.m. EST until 11:59 p.m. EST, customers will ... to 20% off orders $80 or more to free gifts with purchases, there will be ... a competitive e-commerce website for skin care and cosmetic needs, customers will save on already ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, from ... dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. , ... prescription medications. In doing so, it could help to prevent potential overdose situations. ...
(Date:11/27/2015)... Viejo, CA (PRWEB) , ... November 27, 2015 , ... ... for use in Final Cut Pro X. With ProSidebar: Fasion, video editors can ... or use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating drop ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Competitive Intelligence, ... --> ) has ... Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the European Therapeutic Drug Monitoring (TDM) ... Competitive Intelligence, Emerging Opportunities"  report to ... ) has announced the addition of ...
(Date:11/26/2015)... ) has ... Market by Type (Reagents & Kits, Analyzers), ... Diagnostic Labs), Application (Research, Clinical Diagnostics), and ... report to their offering. --> ... the "Radioimmunoassay Market by Type (Reagents ...
Breaking Medicine Technology: