Navigation Links
Newly discovered regulatory mechanism essential for embryo development and may contribute to cancer
Date:10/28/2010

Researchers from Mount Sinai School of Medicine have identified a mechanism controlling the function of a protein that binds to DNA during embryonic development and may function to prevent abnormal tumor growth. When the protein, TCF3, is modified by a small molecule called a phosphate, it no longer binds DNA, changing the way the protein signals during development. This discovery identifies a new diagnostic marker (phosphorylated TCF3) that may be associated with cancer and could represent a potential drug target. The results are published in the current issue of Developmental Cell.

Led by Sergei Sokol, PhD, Professor of Developmental and Regenerative Biology at Mount Sinai School of Medicine, the research team analyzed frog embryos to get a better understanding of how cells "talk" to each other and differentiate into various cell types, e.g., neurons or muscle cells. One such way these cells communicate is through signaling proteins called Wnts, which function during embryonic development and malfunction in cancer, including colon carcinomas, melanomas, skin, lung and liver tumors. Dr. Sokol's team analyzed what happens when a cell responds to Wnt protein..

The researchers' results suggest that Wnt signal activates a special enzyme, called homeodomain-interacting protein kinase that adds a phosphate group to TCF3. This event changes the activity of TCF3 and activates gene expression during early development, allowing embryonic tissues to develop tail structures. Although essential in the early embryo, the same process can cause tumor formation in the adult.

"Our study is the first to show an alternative mechanism of Wnt signaling, that operates in vivo to modulate the activity of TCF3," said Dr. Sokol. "We now know that this change in TCF3 activity leads to a profound alteration of target genes that are important in early development and are abnormally regulated in cancer."

These data potentially provide a diagnos
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Beat The Odds and Get Back on Track; Revitalizing Fitness Training and Exercise Resolutions With Newly Released, Complimentary Video Series
2. Gene discovered for newly recognized disease in Amish children
3. Newly identified proteins critical to FA pathway DNA repair function
4. Khanna Institute to Offer Newly FDA Approved Expanded Range of Intacs for Keratoconus
5. ProbioticSmart.com Re-Launches Newly Expanded Online Store for Human, Pet, and Livestock Health Products and Supplements
6. Newly Relaunched Autoinsurance.net Offers Consumers Smart Tips To Consider When Purchasing Car Insurance
7. Unique and Nutritious Vegetarian Recipes Featured in Newly Released Hand-Bag Friendly “A must have...The Maroema Cook Book”
8. Caregivers Find Hearing Loss Newly Relaunched Website a Welcome Help
9. Altered brain development found in children with newly diagnosed epilepsy
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... 2014 Faculty and staff at Garrison Forest ... in Owings Mills, Md., kicked off the academic year by ... GFS is the first independent school to receive the bands— ... even sleep patterns— as part of a pilot program with ... walking specialty chain. The Vivofit bands are just one tool ...
(Date:9/20/2014)... 2014 Recently, UWDress.com, a professional company ... promotion for its newly announced evening cocktail dresses ... company’s special occasion outfits are very popular among worldwide ... with big savings (up to 65 percent off). ... more fashionable special occasion outfits for the global clients. ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 The Villa ... Villa del Palmar Cabo San Lucas, Villa La Estancia ... to Hurricane Odile, with plans to welcome guests back ... As of Sept. 19, all members and guests of ... thanks to a coordinated effort with government authorities. ...
(Date:9/20/2014)... CA (PRWEB) September 20, 2014 On ... receive a $250,000 pediatric cancer research grant from Hyundai ... Loma Linda University Children’s Hospital located on 11234 Anderson ... work of Dr. Kimberley Payne, Associate Professor at Loma ... work focuses on leukemia in children. , ...
(Date:9/20/2014)... As flu season approaches, the best way to stay ... shot and a checkup, according to an infectious disease ... people against the flu, and also address other health ... provide flu shots for their customers, but they can,t ... director of infection prevention and control for the Loyola ...
Breaking Medicine News(10 mins):Health News:Garrison Forest School Leader in Independent School Wellness Programs 2Health News:Cheap Evening Cocktail Dresses Recently Introduced At UWDress.com 2Health News:Villa Group Resorts in Cabo Largely Unharmed, Plan to Re-open Early October 2Health News:Loma Linda University Medical Center Receives $250,000 Research Grant From Hyundai Hope On Wheels In Honor Of National Childhood Cancer Awareness Month 2Health News:Loma Linda University Medical Center Receives $250,000 Research Grant From Hyundai Hope On Wheels In Honor Of National Childhood Cancer Awareness Month 3Health News:Get a Flu Shot During Checkup, Doctor Says 2
... Insulet Corporation (Nasdaq: PODD ), the ... Insulin Management System, announced plans to release its financial ... 7, 2009 after the close of the financial markets.Insulet ... Eastern Time on Thursday, May 7, 2009 to discuss ...
... 20 The first-ever participation of The Spencer Turbine ... look at the latest Spencer technologies and capabilities. Spencer ... handling system solutions for the process industries.ACHEMA 2009 runs ... Germany. The show, held every three years, is a ...
... beverages may not have same impact, study finds , , ... and other beverages can have a negative effect on ... handle fats, increasing the risk of heart attack and ... beverages don,t have that kind of impact, the study ...
... Research Program and the National Space Biomedical Research ... dozen proposals to help investigate questions about astronaut ... The selected proposals, representing 11 institutions in eight ... million during a three to four-year period.(Logo: ...
... suspect chronic inflammation is common thread among all 3 ... new study lends more credence to a long-suspected connection ... the April issue of the Archives of Dermatology ... the chronic inflammation that is associated with all three ...
... Dr. Steven Laviolette of the Schulich School of Medicine ... found key processes in the brain that control the ... memories of them. A lack of proper brain function ... as Schizophrenia and Post-Traumatic Stress Disorder (PTSD). In people ...
Cached Medicine News:Health News:Insulet Corporation to Report First Quarter 2009 Financial Results on Thursday, May 7, 2009 2Health News:Spencer to Exhibit Air and Gas Handling Equipment Solutions at ACHEMA May 11 - 15, 2009 2Health News:NASA, NSBRI Select 12 Proposals to Support Crew Health on Missions 2Health News:Having Psoriasis Raises Risk of Diabetes, Hypertension 2Health News:Controlling our brain's perception of emotional events 2
(Date:9/19/2014)... 2014 According to the ... Heat, therapy, Hydrotherapy), Accessories (Posture Mirror, Exercise Ball), Applications ... - Global Forecast to 2019" published by MarketsandMarkets, the ... $19,786.3 Million by 2019 from $14,240.0 Million in ... to 2019. Browse 74 market data ...
(Date:9/19/2014)... STATION, N.J. , Sept. 19, 2014 Merck (NYSE: ... United States and Canada , is ... Desafiando La Diabetes: Logra Tus Metas , an educational program ... their blood sugar -- a key treatment goal to help reduce ... United States are at a higher risk for developing ...
(Date:9/19/2014)... 19, 2014 Five MinuteClinic walk-in medical clinics are opening ... metropolitan area. Three clinics opened in Memphis ... clinic will be added in Springfield on ... is expected to open October 22.  MinuteClinic is the largest ... the United States . The Memphis ...
Breaking Medicine Technology:Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3
... (NYSE: MON ) and Pfizer Inc (NYSE: PFE ... for Monsanto to acquire Pfizer,s Chesterfield Village Research Center located ... Monsanto will acquire the property from Pfizer for $435 million ... have operations at Chesterfield Village through a lease agreement, primarily ...
... NATICK, Mass., Nov. 9 Boston Scientific Corporation (NYSE: ... COGNIS® cardiac resynchronization therapy defibrillator (CRT-D) and TELIGEN® implantable ... approved by the Japanese Ministry of Health, Labor and ... September. COGNIS and TELIGEN are the result of ...
Cached Medicine Technology:Monsanto to Purchase Chesterfield Village Research Center From Pfizer 2Monsanto to Purchase Chesterfield Village Research Center From Pfizer 3Boston Scientific's Most Advanced Devices to Treat Heart Failure and Sudden Cardiac Death Now Available in Japan 2Boston Scientific's Most Advanced Devices to Treat Heart Failure and Sudden Cardiac Death Now Available in Japan 3Boston Scientific's Most Advanced Devices to Treat Heart Failure and Sudden Cardiac Death Now Available in Japan 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: