Navigation Links
Newly discovered regulatory mechanism essential for embryo development and may contribute to cancer

Researchers from Mount Sinai School of Medicine have identified a mechanism controlling the function of a protein that binds to DNA during embryonic development and may function to prevent abnormal tumor growth. When the protein, TCF3, is modified by a small molecule called a phosphate, it no longer binds DNA, changing the way the protein signals during development. This discovery identifies a new diagnostic marker (phosphorylated TCF3) that may be associated with cancer and could represent a potential drug target. The results are published in the current issue of Developmental Cell.

Led by Sergei Sokol, PhD, Professor of Developmental and Regenerative Biology at Mount Sinai School of Medicine, the research team analyzed frog embryos to get a better understanding of how cells "talk" to each other and differentiate into various cell types, e.g., neurons or muscle cells. One such way these cells communicate is through signaling proteins called Wnts, which function during embryonic development and malfunction in cancer, including colon carcinomas, melanomas, skin, lung and liver tumors. Dr. Sokol's team analyzed what happens when a cell responds to Wnt protein..

The researchers' results suggest that Wnt signal activates a special enzyme, called homeodomain-interacting protein kinase that adds a phosphate group to TCF3. This event changes the activity of TCF3 and activates gene expression during early development, allowing embryonic tissues to develop tail structures. Although essential in the early embryo, the same process can cause tumor formation in the adult.

"Our study is the first to show an alternative mechanism of Wnt signaling, that operates in vivo to modulate the activity of TCF3," said Dr. Sokol. "We now know that this change in TCF3 activity leads to a profound alteration of target genes that are important in early development and are abnormally regulated in cancer."

These data potentially provide a diagnostic or therapeutic target in identifying and treating common types of cancer. If the presence of the phosphate molecule on TCF3 is identified, then the cancer may be caught earlier, providing more treatment options. Additionally, knowing that this modification of TCF3 may cause abnormal cell growth would allow researchers to develop drugs that can inhibit its action.

"While more research is needed, our study is a promising first step toward earlier diagnosis and better treatment for many common cancers," said Dr. Sokol. "We look forward to gaining further understanding of the role of TCF regulation for gene expression."


Contact: Mount Sinai Press Office
The Mount Sinai Hospital / Mount Sinai School of Medicine

Related medicine news :

1. Beat The Odds and Get Back on Track; Revitalizing Fitness Training and Exercise Resolutions With Newly Released, Complimentary Video Series
2. Gene discovered for newly recognized disease in Amish children
3. Newly identified proteins critical to FA pathway DNA repair function
4. Khanna Institute to Offer Newly FDA Approved Expanded Range of Intacs for Keratoconus
5. Re-Launches Newly Expanded Online Store for Human, Pet, and Livestock Health Products and Supplements
6. Newly Relaunched Offers Consumers Smart Tips To Consider When Purchasing Car Insurance
7. Unique and Nutritious Vegetarian Recipes Featured in Newly Released Hand-Bag Friendly “A must have...The Maroema Cook Book”
8. Caregivers Find Hearing Loss Newly Relaunched Website a Welcome Help
9. Altered brain development found in children with newly diagnosed epilepsy
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements.
Post Your Comments:
(Date:11/27/2015)... ... ... ProSidebar: Fashion is a set of 30 kinetic edge graphics ... editors can easily add an informative sidebar to any FCPX production. Create lists, ... self-animating drop zones, lines, bars, and text with the ease of FCPX's drag and ...
(Date:11/27/2015)... DE (PRWEB) , ... November 27, 2015 , ... ... member of the well-respected Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s ... an independent group of Microsoft Dynamics SL software users, partners, industry experts and ...
(Date:11/27/2015)... ... 2015 , ... Keeping in mind challenges faced by parents ... consultation, has collaborated with a leading web-based marketplace for extra-curricular activities for children ... and bring advice from parenting experts within their reach. As a part of ...
(Date:11/27/2015)... ... November 27, 2015 , ... Dr. Thomas Dunlap and ... and Dr. Tucker Bierbaum with Emergency Medicine at St., Joseph Health System’s Santa ... and Sepsis conditions present in similar ways and require time-critical intervention to avoid large ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... potential to use SyMRI to find optimal contrast weighting of ... tumor metastases, and has signed a research agreement with SyntheticMR ... the hospital. Using SyMRI, it is possible to generate multiple ... settings after the patient has left, thus making it possible ...
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Competitive Intelligence, ... --> ) has ... Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
Breaking Medicine Technology: