Navigation Links
Newly discovered esophagus stem cells grow into transplantable tissue, Penn study finds
Date:12/15/2008

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have discovered stem cells in the esophagus of mice that were able to grow into tissue-like structures and when placed into immune-deficient mice were able to form parts of an esophagus lining. The investigators report their findings online this month in the Journal of Clinical Investigation.

"The immediate implication is that we'll have a better understanding of the role of these stem cells in normal biology, as well as in regenerative and cancer biology," says senior author Anil K. Rustgi, MD, the T. Grier Miller Professor of Medicine and Genetics and Chief of Gastroenterology. "Down the road, we will develop a panel of markers that will define these stem cells and use them in replacement therapy for diseases like gastroesophogeal reflux disease [GERD] and also to understand Barrett's esophagus, a precursor to esophageal adenocarcinoma and how to reverse that before it becomes cancer."

Diseases of the esophagus are very common in the United States and worldwide. "Benign forms include GERD and millions are affected," notes Rustgi.

GERD can sometimes lead to inflammation of the esophagus, called esophagitis. "In some of these cases esophagitis can lead to a swapping of the normal lining of the esophagus with a lining that looks more like the intestinal lining and that's called Barrett's esophagus," explains Rustgi. "This can lead to cancer of the esophagus, which is the fastest rising cancer in the US, increasing by 7 to 8 percent a year."

The researchers set out to identify and characterize potential stem cells--those with the ability to self renew--in the esophagus to understand normal biology and how injured cells may one day be repaired.

First, they grew mouse esophageal cells they suspected were adult stem cells. Those cells formed colonies that self renewed. These cells then grew into esophageal lining tissue in a three-dim
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. First study examines newly-licensed RN work attitudes and intentions
2. Common abdominal pain may be due to a potentially treatable newly recognized inflammatory reaction
3. Higher death rates in kidney patients with newly recognized disease
4. Newly Published Study in Leading Medical Journal Further Confirms the Brava Systems Non-Surgical Breast Enhancement Effectiveness
5. Natural Nutrition Expands Revenue Capabilities with Newly Installed State of the Art Nutrition Bar Line
6. Corrected & Replaced - Natural Nutrition Expands Revenue Capabilities with Newly Installed State of the Art Nutrition Bar Line
7. Hidden Costs Plague Owners Occupying Newly Constructed Buildings; New Program Can Help Avoid Major Issues
8. Striking shift seen among newly HIV-infected men regarding partners
9. Newly HIV-Infected Gay Men Select Other Infected Partners
10. Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75
11. New therapeutic options for newly diagnosed multiple myeloma patients

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newly discovered esophagus stem cells grow into transplantable tissue, Penn study finds
Newly discovered esophagus stem cells grow into transplantable tissue, Penn study finds
(Date:11/9/2009)...rchers find long-term risks, but not all agree , ...ing sinuses with a saline solution might have soot...ke you more prone to infections in the long run by..., "By washing the nose, we are removing the bad...e good mucus that contains the antimicrobial agent...
(Date:11/9/2009)... Industry leader readies its a...lly migrate to and reduce IT risk on Windows 7 and... plans with solution readiness. , ..., , , ,News Facts ,   As businesses ...indows 7 and Windows 2008 Server R2, Lumension , ...
(Date:11/9/2009)... NBC’s Today Show featur...ian, Dr. Jill Waibel on Friday Nov. 6th 2009, The... Berns after their first appearance on the Today S...d by Matt Lauer regarding their treatments by Dr. ...Pulse TotalFX laser. , (P...
(Date:11/9/2009)... This device is ideal for endu...t and is available at ShopCompex.com , ...09 -- Compex®, a brand of DJO Incorporated, a ...s, is pleased to announce the launch of the latest...Compex Sport Elite. The Sport Elite was designed t...
(Date:11/9/2009)... Vancouver Career College laun... Surrey, BC (Vocus) November 9...er College in Surrey are digging through their clo... Surrey citizens to do the same in order to help w...ay we focus on building a community here on campus...
Breaking Medicine News(10 mins):Health News:Sinus Rinses May Do More Harm Than Good 2Health News:Sinus Rinses May Do More Harm Than Good 3Health News:Lumension Provides Enhanced Endpoint Protection and Support for The Latest Windows Platforms 2Health News:Lumension Provides Enhanced Endpoint Protection and Support for The Latest Windows Platforms 3Health News:Lumension Provides Enhanced Endpoint Protection and Support for The Latest Windows Platforms 4Health News:Lumenis Ultrapulse TotalFX Featured for the Treatment of Burn Scars on the Today Show 2Health News:Lumenis Ultrapulse TotalFX Featured for the Treatment of Burn Scars on the Today Show 3Health News:Lumenis Ultrapulse TotalFX Featured for the Treatment of Burn Scars on the Today Show 4Health News:COMPEX Intoduces New Sport Elite Electrical Muscle Stimulation Unit 2Health News:COMPEX Intoduces New Sport Elite Electrical Muscle Stimulation Unit 3Health News:Surrey College Students Collect Clothing for Women and Children 2
...ificial heart was approved by the U.S. Food and Dr...al heart has been approved for patients with sever...plant. Under the FDA's Humanitarian Use Device... per year. The usage of this artificial heart is r...
... about 300 million poultry next month against bird...ls in the midst of large-scale criticism over the ...nced that the government plans of mass vaccination...rged Jakarta to give precedence for controlling th...
...em that could help in determining the condition of...do Silvio Nu?o Almirantearena has developed a new ...rt attack, brain stroke or high blood pressure, by...agnosis of the condition of the arterial system in...
...of Clinical Investigation and the September issue ... Monash University have reported that a new drug h...nd heart attacks by improving the blood flow in di... of the arteries. The finding is a significa...
... Zero after 9/11 are struggling with serious healt...to advocates.// "When we were needed on 9/11, no o...re anymore," said Lucelly Gil, who was present in ... necessary protection. "All of us who worked in th...
...t it has asked EU health authorities to re-examine...reatment Tarceva.// The European Committee for Me... rejected the Tarceva application. "People wi...ady been approved for this indication in the US," ...
Other Medicine News:Health News:First Implantable artificial heart gets FDA’s approva 2Health News:Indonesia To Conduct Mass Vaccination Of Poultry 2Health News:A New System Developed For Studying The Condition Of The Human Arterial System 2Health News:A New Drug That Could Revolutionize Management Of Heart Disease 2
(Date:11/6/2009)..., BOTHELL, Wash., Nov. 6 /PRNewswire-FirstCall/ -...financial results for the three and nine months en... SCOLR Pharma,s President and CEO, said, "We conti...r 12-hour ibuprofen formulation. Several potential...time, personnel and external resources as they eva...
(Date:11/6/2009)..., ,, FORT WASHINGTON, Pa., Nov. 6 /PRNewsw...g Administration (FDA), McNeil Consumer Healthcare...luntary recall of a limited number of product lots...bottles, with the distinctive red EZ-OPEN CAP. McN...uncharacteristic smell or taste associated with th...
(Date:11/6/2009)..., MORRISTOWN, N.J., Nov. 6 /PRNewswire-FirstCall/...leading specialty pharmaceutical company, announce...hief executive officer, will provide an overview a...Suisse 18th Annual Healthcare Conference on Wednes...d Time. ,, This presentation will be webcast li...
Breaking Medicine Technology:SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 2SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 3SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 4SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 5SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 6SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 7SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 8SCOLR Pharma, Inc. Reports Third Quarter 2009 Financial Results 9McNeil Consumer Healthcare Announces Voluntary Recall of Certain Lots of TYLENOL(R) Arthritis Pain 100 Count with EZ-OPEN CAP 2Avalere Estimates Medicare Part D Donut Hole Will Be Obsolete in 2023 50579 1Avalere Estimates Medicare Part D Donut Hole Will Be Obsolete in 2023 50579 2Materials and Processes for Medical Devices Event Brings Clinicians Engineers Designers Together 50574 1Materials and Processes for Medical Devices Event Brings Clinicians Engineers Designers Together 50574 2Materials and Processes for Medical Devices Event Brings Clinicians Engineers Designers Together 50574 3Materials and Processes for Medical Devices Event Brings Clinicians Engineers Designers Together 50574 4Lung Cancer Alliance Praises Congresswoman Donna Christensen for Introduction of Legislation to Correct Healthcare Disparities 50569 1Lung Cancer Alliance Praises Congresswoman Donna Christensen for Introduction of Legislation to Correct Healthcare Disparities 50569 2
...s, a division of Wyeth (NYSE: WYE ), announced to...A) has issued an approvable letter for,the first-i...e treatment of,adult patients with community-acqui...he FDA requested that Wyeth provide,additional ana...L for the,treatment of patients with CAP with illn...
...development in treatment-experi...Mune, Inc.,(Nasdaq: ITMN ) today announced that i...evaluating ITMN-191, designated R7227 at Roche (SW...interferon alpha-2a) and,Copegus(R) (ribavirin) in...patitis C virus (HCV) genotype 1 infection., Inte...
Other Medicine Technology:Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia 2Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia 3Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia 4Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia 5Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia 6InterMune Announces Start of 14-Day Triple Combination Study of ITMN-191 in Patients With Chronic Hepatitis C 2InterMune Announces Start of 14-Day Triple Combination Study of ITMN-191 in Patients With Chronic Hepatitis C 3InterMune Announces Start of 14-Day Triple Combination Study of ITMN-191 in Patients With Chronic Hepatitis C 4
...onal reference laboratory and a worldwide leader i...ARUP offers an extensive test menu of highly compl...ic pathology. Owned by the University of Utah, ARU...the nation's university teaching hospitals and chi...
...onal reference laboratory and a worldwide leader i...ARUP offers an extensive test menu of highly compl...ic pathology. Owned by the University of Utah, ARU...the nation's university teaching hospitals and chi...
...onal reference laboratory and a worldwide leader i...ARUP offers an extensive test menu of highly compl...ic pathology. Owned by the University of Utah, ARU...the nation's university teaching hospitals and chi...
...onal reference laboratory and a worldwide leader i...ARUP offers an extensive test menu of highly compl...ic pathology. Owned by the University of Utah, ARU...the nation's university teaching hospitals and chi...
Medicine Products: