Navigation Links
Newly Identified Gene Variants Linked to Diabetes
Date:1/18/2010

Discovery could lead to new type 2 treatments, researchers say

MONDAY, Jan. 18 (HealthDay News) -- Researchers have identified 10 new gene variants associated with blood sugar or insulin levels, which they believe could lead to new treatments for type 2 diabetes.

"Only four gene variants had previously been associated with glucose metabolism, and just one of them was known to affect type 2 diabetes. With more genes identified, we can see patterns emerge," study co-lead author Dr. Jose Florez, of the Diabetes Unit and the Center for Human Genetic Research at Massachusetts General Hospital, said in a news release.

"Finding these new pathways can help us better understand how glucose is regulated, distinguish between normal and pathological glucose variations and develop potential new therapies for type 2 diabetes," Florez explained.

The study is published in the Jan. 17 online edition of the journal Nature Genetics.

The international team of researchers began their study by analyzing about 2.5 million gene variations (called SNPs) from 21 genome-wide searches for variants associated with glucose and insulin regulation in more than 46,000 people without diabetes. The 25 most promising SNPs were further investigated and narrowed down to 10 new SNPs associated with blood sugar and insulin levels, and increased diabetes risk.

"The fact that not all genes involved with raising glucose levels increase diabetes risk tells us that it's not the mere fact of raising glucose that's important but rather how glucose is raised. It's one thing to increase glucose slightly within the normal range and quite another to affect a pathway that eventually leads to progressive glucose elevation, beta-cell failure or insulin resistance -- in other words type 2 diabetes," Florez said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.



-- Robert Preidt



SOURCE: Massachusetts General Hospital, news release, Jan. 17, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Newly identified genes influence insulin and glucose regulation
2. Research confirms efficacy of the newly reclassified TMN staging system
3. Newly discovered mechanism by which blood clots form
4. Newly revised guidelines for managing thyroid cancer published in Thyroid journal
5. Aviva Family and Childrens Services Hosts Rededication Ceremony of the Newly Renovated Wallis Annenberg Center
6. Newly Published Clinical Study Finds New Commercial Diet Program Superior to Standard Protocol for Diabetes Weight Loss and Blood Sugar Control
7. Newly Formed American Society for Nanomedicine (ASNM) to Hold First Conference (www.amsocnanomed.org)
8. Familiar and newly learned words are processed by the same neural networks in the brain
9. Newly discovered mechanism in cell division has implications for chromosomes role in cancer
10. MRI may be unnecessary prior to treatment in most newly diagnosed breast cancer patients
11. Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
Breaking Medicine Technology: