Navigation Links
Newly Identified Gene Variants Linked to Diabetes
Date:1/18/2010

Discovery could lead to new type 2 treatments, researchers say

MONDAY, Jan. 18 (HealthDay News) -- Researchers have identified 10 new gene variants associated with blood sugar or insulin levels, which they believe could lead to new treatments for type 2 diabetes.

"Only four gene variants had previously been associated with glucose metabolism, and just one of them was known to affect type 2 diabetes. With more genes identified, we can see patterns emerge," study co-lead author Dr. Jose Florez, of the Diabetes Unit and the Center for Human Genetic Research at Massachusetts General Hospital, said in a news release.

"Finding these new pathways can help us better understand how glucose is regulated, distinguish between normal and pathological glucose variations and develop potential new therapies for type 2 diabetes," Florez explained.

The study is published in the Jan. 17 online edition of the journal Nature Genetics.

The international team of researchers began their study by analyzing about 2.5 million gene variations (called SNPs) from 21 genome-wide searches for variants associated with glucose and insulin regulation in more than 46,000 people without diabetes. The 25 most promising SNPs were further investigated and narrowed down to 10 new SNPs associated with blood sugar and insulin levels, and increased diabetes risk.

"The fact that not all genes involved with raising glucose levels increase diabetes risk tells us that it's not the mere fact of raising glucose that's important but rather how glucose is raised. It's one thing to increase glucose slightly within the normal range and quite another to affect a pathway that eventually leads to progressive glucose elevation, beta-cell failure or insulin resistance -- in other words type 2 diabetes," Florez said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.



-- Robert Preidt



SOURCE: Massachusetts General Hospital, news release, Jan. 17, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Newly identified genes influence insulin and glucose regulation
2. Research confirms efficacy of the newly reclassified TMN staging system
3. Newly discovered mechanism by which blood clots form
4. Newly revised guidelines for managing thyroid cancer published in Thyroid journal
5. Aviva Family and Childrens Services Hosts Rededication Ceremony of the Newly Renovated Wallis Annenberg Center
6. Newly Published Clinical Study Finds New Commercial Diet Program Superior to Standard Protocol for Diabetes Weight Loss and Blood Sugar Control
7. Newly Formed American Society for Nanomedicine (ASNM) to Hold First Conference (www.amsocnanomed.org)
8. Familiar and newly learned words are processed by the same neural networks in the brain
9. Newly discovered mechanism in cell division has implications for chromosomes role in cancer
10. MRI may be unnecessary prior to treatment in most newly diagnosed breast cancer patients
11. Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... ... enhance people’s everyday lives, recently attended the January ECRM Trade Show in Hilton ... is known for its large range of supplements that keep the body functioning ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Mary Magdalene: Grace is Greater than Sin”: ... who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace is Greater than Sin” is the ... an educator interacting with countless women who had little knowledge of the female characters ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Christmas in Suffolk”: ... published author, Sara Seymour, who lives in Lafayette, Indiana where she works in a ... iced coffees and writes. , Published by Christian Faith Publishing, Sara Seymour’s new book ...
(Date:1/19/2017)... (PRWEB) , ... January 20, 2017 , ... Today, the ... to participate in four of CMS’s Alternative Payment Models (APMs) in 2017. Clinicians who ... patients. APMs are an important part of the Administration’s effort to build a ...
(Date:1/19/2017)... , ... January 19, 2017 , ... This month, the ... that the name of their drug rehab center in Delray Beach, Florida has been ... that not only stars such as Philip Seymour Hoffman and Chris Farley are dying ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... YORK , Jan. 19, 2017 This ... the current and future scenario of the global market. ... rising opioid consumption. Severe chronic constipation is a major ... to traditional laxatives. Hence, novel targeted therapy has been ... OIC sufferers, launch of targeted medicines, and growing awareness ...
(Date:1/19/2017)... 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ), ... dysfunction, today announced new additions to its senior leadership ... Medical Officer, and Daniel Geffken as interim ... Jim Carr , Pharm.D. has been promoted to Chief ... to welcome Doug and Daniel to our management team, ...
(Date:1/19/2017)... 2017 According to a study conducted by ... to witness a CAGR of 6.5% during the forecast period 2016-2024. ... continue to be the leading market for cryotherapy globally during the ... Highlights ... ensuring affordable and adequate supply of gas in order to provide ...
Breaking Medicine Technology: