Navigation Links
Newly Identified Gene Variants Linked to Diabetes

Discovery could lead to new type 2 treatments, researchers say

MONDAY, Jan. 18 (HealthDay News) -- Researchers have identified 10 new gene variants associated with blood sugar or insulin levels, which they believe could lead to new treatments for type 2 diabetes.

"Only four gene variants had previously been associated with glucose metabolism, and just one of them was known to affect type 2 diabetes. With more genes identified, we can see patterns emerge," study co-lead author Dr. Jose Florez, of the Diabetes Unit and the Center for Human Genetic Research at Massachusetts General Hospital, said in a news release.

"Finding these new pathways can help us better understand how glucose is regulated, distinguish between normal and pathological glucose variations and develop potential new therapies for type 2 diabetes," Florez explained.

The study is published in the Jan. 17 online edition of the journal Nature Genetics.

The international team of researchers began their study by analyzing about 2.5 million gene variations (called SNPs) from 21 genome-wide searches for variants associated with glucose and insulin regulation in more than 46,000 people without diabetes. The 25 most promising SNPs were further investigated and narrowed down to 10 new SNPs associated with blood sugar and insulin levels, and increased diabetes risk.

"The fact that not all genes involved with raising glucose levels increase diabetes risk tells us that it's not the mere fact of raising glucose that's important but rather how glucose is raised. It's one thing to increase glucose slightly within the normal range and quite another to affect a pathway that eventually leads to progressive glucose elevation, beta-cell failure or insulin resistance -- in other words type 2 diabetes," Florez said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.

-- Robert Preidt

SOURCE: Massachusetts General Hospital, news release, Jan. 17, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Newly identified genes influence insulin and glucose regulation
2. Research confirms efficacy of the newly reclassified TMN staging system
3. Newly discovered mechanism by which blood clots form
4. Newly revised guidelines for managing thyroid cancer published in Thyroid journal
5. Aviva Family and Childrens Services Hosts Rededication Ceremony of the Newly Renovated Wallis Annenberg Center
6. Newly Published Clinical Study Finds New Commercial Diet Program Superior to Standard Protocol for Diabetes Weight Loss and Blood Sugar Control
7. Newly Formed American Society for Nanomedicine (ASNM) to Hold First Conference (
8. Familiar and newly learned words are processed by the same neural networks in the brain
9. Newly discovered mechanism in cell division has implications for chromosomes role in cancer
10. MRI may be unnecessary prior to treatment in most newly diagnosed breast cancer patients
11. Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... ... Center is one of a select few plastic surgeons in the New York ... removal. , SculpSure™ is the world’s first heat-induced laser treatment for fat loss ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... TransPack Volume ... X . Choose from scrolling web-styled transitions to wipes with blur & drop ... direction and more. Seamlessly transition from one clip to the next with TransPack's ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... their strategic partnership at the Radiological Society of North America (RSNA) 2015 ... global providers of cutting-edge dictation and speech-enabled documentation software, announced their partnership ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... In 2016, expected coding changes are likely to include new codes for spine ... not easy to understand the effects of code changes in musculoskeletal, radiology and ...
(Date:11/30/2015)... ... 30, 2015 , ... CTI Group (Holdings) Inc. (OTC:CTIG), a ... communication analytics, announced today that their Proteus® VoIP QMS solution now supports Skype ... Proteus® VoIP QMS (Quality Management System) does this by collecting the ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Royal Philips (NYSE: PHG AEX: PHIA) ... user interface and automatic scan parameter selection to help ... such as knee and hip replacements, spine implants and ... America Annual Meeting (RSNA) . The new software helps ... growing patient population. ScanWise Implant adds to Philips, suite ...
(Date:11/30/2015)... and BOCA RATON, Fla. , Nov. ... Commercialization of Public Research (the Institute) announced today ... KynderMed , a medical device start-up company with technology ... company creation based on publicly-funded research, and bridges early ... Florida -based universities and research institutions. ...
(Date:11/30/2015)... , Nov. 30, 2015 ... global biopharmaceutical leader dedicated to delivering transformative ... underserved medical conditions, today announced the launch ... (Recombinant), PEGylated], an extended circulating half-life recombinant ... based on full-length ADVATE [Antihemophilic Factor (Recombinant)]. ...
Breaking Medicine Technology: