Navigation Links
Newly Created Rats Designed to Speed Alzheimer's Research
Date:4/10/2013

termed "neurofibrillary tangles."

The newly created transgenic rats are the first rodents to have mutations that effectively reproduce those brain changes, according to the research published April 9 in the Journal of Neuroscience.

From studying the genetically engineered rats, the researchers have confirmed the role of amyloid plaques in the development of the disease and discovered specialized glial cells (neural support cells) before the development of amyloid plaque. That suggests that activation of those cells could potentially become a new treatment target, according to Town. "We may be able to see subtle changes in humans earlier than we thought in people who are predisposed to Alzheimer's."

To create a transgenic rat, "you take a disease-causing gene from a human and you put it into an animal," Town explained. "You make a line of animals, just like you would with dogs or horses, to transmit that gene."

The scientists then test to be sure the rat progeny have evidence of the genetic changes and allow them to age. Rats typically have a three-year lifespan, so 16-month-old rats are like people in their 40s and 2-month-olds are like those in their 80s, Town noted.

The researchers tested the transgenic rats to confirm the presence of the neurofibrillary tangles in areas of the brain involved in learning and memory. They also found evidence that 30 percent of the rats' brain neurons in these areas died as the rats aged, with some glial cells forming themselves into shapes similar to those found in human patients.

Heather Snyder, director of medical and scientific operations for the Alzheimer's Association, said the research represents the first time critical processes and pathologies of the disease have been replicated in an animal model. But she warned that animal models are limited.

"Rats are not humans and animals do not develop Alzheimer's," Snyder noted. "This is something that is still being manipu
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Newly Updated Fact Sheet Suggests that Vitamin B6, Which is Found in Popular Weight Loss Supplement Liproxenol, May Ease Carpal Tunnel Syndrome
2. hCGTreatments / Diet Doc hCG Diet & Weight Loss Plans Introduces Newly Reformulated Prescription Saffron Extract Diet Pills
3. Astro-Clairvoyant Norah Guide With Premium Astrology Extends Blog Series With Newly Added Video Features
4. hCGTreatments / Diet Doc hCG Diets and Weight Loss Plans Announces The Newly Improved Prescription hCG Diet Plans Designed To Promote Fast Weight Loss Without Exercise
5. Long-Time-Liner® Beverly Hills advises on the key points to seek in a qualified technician for those considering the newly emerging permanent make-up trend.
6. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Reports Newly Designed Prescription hCG Diet Plans Beneficial in Reducing Painful And Chronic Joint Pain
7. Newly Release Video Reveals Technical aspects of Advanced Breast Augmentation Surgery The Cold-Subfascial Breast Augmentation TM
8. "Hey, Little Boys can Glam-Up Too!" Newly Released Children's Book Written by Patrice Colamesta and Illustrated by Leo Silva: Sibling Rivalry at its Best
9. Newly incarcerated have 1 percent acute hepatitis C prevalence
10. The newly redesigned Chicago Skin Cancer Surgery Website is Officially Finished
11. Stroke risk in elderly treated with antipsychotics is newly linked to specific drug actions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newly Created Rats Designed to Speed Alzheimer's Research
(Date:4/17/2015)... 17, 2015 From the day Dr. Todd ... Texas non-profit organization has empowered young people to create meaningful ... bring fresh water and the Gospel to all of ... Between March 17 and 27, students, faculty and staff raised ... with fresh water and the Good News of Jesus. ...
(Date:4/17/2015)... Enthusiasts of gourmet cuisine and beverages will be ... The event will be held in the heart of downtown ... NW, Grand Rapids, MI 49503) and will feature wine personalities ... are encouraged to savor the food and beverage pairings while ... event will feature seven chefs, including:, ...
(Date:4/17/2015)... 2015 Testosterone treatment lawsuits ( ... prescription medications increases the likelihood that a man ... life-threatening cardiovascular event continue to mount in a ... District of Illinois. According to an updated Statistics ... Multidistrict Litigation (JPML) on April 15th, 1,382 cases ...
(Date:4/17/2015)... Francisco, CA (PRWEB) April 17, 2015 The American ... House event and Free Application Day on April 29. The event ... ACTCM Pioneer Square, located at 555 DeHaro St. in San Francisco, ... 11 a.m. – Check in at the DeHaro campus (room F), ... – Tour of campus, Noon – Light lunch with current students, ...
(Date:4/17/2015)... North Carolina (PRWEB) April 17, 2015 ... Family Dental Care has spent the last four ... dental care, performing procedures ranging from general cleanings to ... host a grand opening at their new office in ... the same services as their Concord office, including denture ...
Breaking Medicine News(10 mins):Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4Health News:American College of Traditional Chinese Medicine Hosts Open House 2
... LAKE CITY, Oct. 22 /PRNewswire/, WHAT: In response to the ... Children,s Miracle Network hospitals are on call to answer ... (MRSA), a form of ... antibiotics, and other pediatric medical questions you have., ...
... American Red Cross encourages evacuees to register on Safe ... continue to rage across,Southern California, forcing thousands to evacuate ... help for those who may feel confused,and anxious about ... The Red Cross urges all those who have evacuated ...
... ... Double Adjusted EBITDA in Fourth Quarter of ... 2007, ... of health, beauty, vision, and,pharmacy products, today announced its financial results for the third,quarter ...
... Says VA Refuses to Act in Good Faith ... Oct. 22 The American Federation,of Government Employees ... Florida/South Georgia Veterans Health System (NF/SGVHS), today,criticized the ... act in,good faith with its employees by failing ...
... world,s adults are obese, study finds , , MONDAY, Oct. 22 ... percent of women are now overweight, and 24 percent of ... who looked at data from 63 countries. , The study ... 18-80 (average age 48), living on five continents. All of ...
... of each extraordinary gift to benefit St. Jude ... Children,s Research Hospital -, ... has created five exclusive, over-the-top luxury gifts available for,purchase beginning October ... Jude Children,s Research Hospital. Each extravagant gift was inspired by ...
Cached Medicine News:Health News:Children's Miracle Network Hospital Doctors On Call to Answer Questions About MRSA Infection 2Health News:Southern California Wildfires Continue to Threaten Residential Areas 2Health News:Southern California Wildfires Continue to Threaten Residential Areas 3Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 2Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 3Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 4Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 5Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 6Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 7Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 8Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 9Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 10Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 11Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 12Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 13Health News:drugstore.com inc. Reports Record Gross Margins and Bottom Line Results for the Third Quarter of 2007 14Health News:Mismanagement at North Florida/South Georgia Veterans Health System Results in Chronic Staff Shortages, Budget Issues 2Health News:Overweight Now a Global Problem 2Health News:Saks Fifth Avenue Unveils Five Magical Holiday Gifts 2Health News:Saks Fifth Avenue Unveils Five Magical Holiday Gifts 3
(Date:4/17/2015)... , April 17, 2015 ... EGFR mutation   is a viable alternative to tumour biopsy ... testing in all patients with advanced NSCLC   ... effectiveness of plasma circulating tumour DNA (ctDNA) testing for epidermal ... with advanced non-small cell lung cancer (NSCLC) in clinical practice. ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/5hkm2f/medical_oxygen ) ... Systems - Global Strategic Business Report" report to ... markets for Medical Oxygen Systems in US$ Thousands by ... Cylinders & Regulators, and Oxygen Conserving Devices. The report ... Canada , Japan , ...
(Date:4/17/2015)... Apr. 16, 2015 Research and Markets ... "Corporate Reputation of Pharma in 2014 - a ... report to their offering. This independent study, ... patient groups with an interest in diabetes on the ... the pharma industry as a whole) in 2014. The ...
Breaking Medicine Technology:"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 2"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 3"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 4Medical Oxygen Systems - 2015 Global Strategic Business Report Featuring Leading Players, Caire, Invacare & Philips Respironics 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 3Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 4Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 5
... YORK, Nov. 4, 2010 Reportlinker.com ... report is available in its catalogue: ... Cancer Overview - Metastatic gastrointestinal cancers ... to a lack of approved drugs ...
... YORK, Nov. 4 Reportlinker.com announces that ... in its catalogue: Stakeholder ... - Opportunities in Brazil, Mexico and Argentina ... IntroductionOver the past decade, vaccines ...
Cached Medicine Technology:Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 2Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 3Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 4Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 5Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 6Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 7Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 8Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 9Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 10Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 11Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 12Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 13Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 14Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 15Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 16Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs 17Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 2Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 3Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 4Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 5Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 6Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 7Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 8
Straight curette with hollow handle and round cup....
Set of 5 large bone curettes. One each of the following: angled small, straight small, angled medium, straight medium, and angled large....
Bone removing chisel for decortication of lumbar vertebral bodies....
Stainless steel bone clamp....
Medicine Products: