Navigation Links
Newly Created Rats Designed to Speed Alzheimer's Research

By Barbara Bronson Gray
HealthDay Reporter

WEDNESDAY, April 10 (HealthDay News) -- Everyone wants to build a better mousetrap, but researchers working to uncover the secrets of Alzheimer's disease have taken that a step further: They've built a better rat.

By creating genetically engineered lab animals that more closely mirror key elements of Alzheimer's in the human brain, scientists report they have created a more effective, faster approach for early testing of potential drugs to treat the disease.

These "transgenic" rats are better lab animals than are other rodents for a variety of reasons, according to study author Terrence Town, a professor in the physiology and biophysics department at the Keck School of Medicine at the University of Southern California. "You get so much more usable data from these rats."

"First, the typical rat, which is 5 million years closer to the human than the mouse is, is a better model for pathology than the mouse," Town said. Mice have typically been seen as the preferred lab animal because rats are four times more expensive to house, he noted.

Because the genetically altered rats are designed to develop specific pathologies seen in Alzheimer's, these rodents could help researchers better understand the disease process and test new therapeutics, he explained. "With mice models, you can cure them with lots of things but none have translated to humans, and we believe we're now going to close the gap with these rats."

Alzheimer's disease, which affects at least 5.1 million Americans, is an age-related dementia that gradually destroys a person's memory, thinking and the ability to carry out simple tasks.

Scientists have found that brain evidence of the disease includes the loss of neurons, or nerve cells; the development of abnormal levels of proteins that form what are called amyloid plaques, and the clumping of "tau proteins" inside neurons, forming what are termed "neurofibrillary tangles."

The newly created transgenic rats are the first rodents to have mutations that effectively reproduce those brain changes, according to the research published April 9 in the Journal of Neuroscience.

From studying the genetically engineered rats, the researchers have confirmed the role of amyloid plaques in the development of the disease and discovered specialized glial cells (neural support cells) before the development of amyloid plaque. That suggests that activation of those cells could potentially become a new treatment target, according to Town. "We may be able to see subtle changes in humans earlier than we thought in people who are predisposed to Alzheimer's."

To create a transgenic rat, "you take a disease-causing gene from a human and you put it into an animal," Town explained. "You make a line of animals, just like you would with dogs or horses, to transmit that gene."

The scientists then test to be sure the rat progeny have evidence of the genetic changes and allow them to age. Rats typically have a three-year lifespan, so 16-month-old rats are like people in their 40s and 2-month-olds are like those in their 80s, Town noted.

The researchers tested the transgenic rats to confirm the presence of the neurofibrillary tangles in areas of the brain involved in learning and memory. They also found evidence that 30 percent of the rats' brain neurons in these areas died as the rats aged, with some glial cells forming themselves into shapes similar to those found in human patients.

Heather Snyder, director of medical and scientific operations for the Alzheimer's Association, said the research represents the first time critical processes and pathologies of the disease have been replicated in an animal model. But she warned that animal models are limited.

"Rats are not humans and animals do not develop Alzheimer's," Snyder noted. "This is something that is still being manipulated by the scientists -- animal models are an early tool in research. So, while this type of research and this type of advance in the field is important, this is still basic science."

Town said his hope is that the transgenic rats will help researchers uncover principles applicable to other neurological diseases, such as amyotrophic lateral sclerosis -- also known as ALS or Lou Gehrig's disease -- and Parkinson's disease. "As we make this model available to the research community, our hope is that it will be useful in basic research and treatment development," he said.

More information

Learn more about Alzheimer's disease from the U.S. National Institute of Neurological Disorders and Stroke.

SOURCES: Terrence Town, Ph.D., professor, department of physiology and biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles; Heather M. Snyder, Ph.D., director, medical and scientific operations, Alzheimer's Association, Chicago; April 9, 2013, Journal of Neuroscience

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Newly Updated Fact Sheet Suggests that Vitamin B6, Which is Found in Popular Weight Loss Supplement Liproxenol, May Ease Carpal Tunnel Syndrome
2. hCGTreatments / Diet Doc hCG Diet & Weight Loss Plans Introduces Newly Reformulated Prescription Saffron Extract Diet Pills
3. Astro-Clairvoyant Norah Guide With Premium Astrology Extends Blog Series With Newly Added Video Features
4. hCGTreatments / Diet Doc hCG Diets and Weight Loss Plans Announces The Newly Improved Prescription hCG Diet Plans Designed To Promote Fast Weight Loss Without Exercise
5. Long-Time-Liner® Beverly Hills advises on the key points to seek in a qualified technician for those considering the newly emerging permanent make-up trend.
6. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Reports Newly Designed Prescription hCG Diet Plans Beneficial in Reducing Painful And Chronic Joint Pain
7. Newly Release Video Reveals Technical aspects of Advanced Breast Augmentation Surgery The Cold-Subfascial Breast Augmentation TM
8. "Hey, Little Boys can Glam-Up Too!" Newly Released Children's Book Written by Patrice Colamesta and Illustrated by Leo Silva: Sibling Rivalry at its Best
9. Newly incarcerated have 1 percent acute hepatitis C prevalence
10. The newly redesigned Chicago Skin Cancer Surgery Website is Officially Finished
11. Stroke risk in elderly treated with antipsychotics is newly linked to specific drug actions
Post Your Comments:
Related Image:
Newly Created Rats Designed to Speed Alzheimer's Research
(Date:11/27/2015)... Los Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... new study carried out by the University of Toronto and the University of British ... number of hospitalizations for head injuries. The article explains that part of the reason ...
(Date:11/27/2015)... ... 2015 , ... "When I was traveling, I was very ... "Many people catch diseases simply from sitting on such dirty toilet seats. I ... germs." , He developed the patent-pending QUDRATECS to eliminate the need to sit ...
(Date:11/27/2015)... ... 27, 2015 , ... Consistent with the Radiology Business ... Better Radiology Marketing Programs meeting will showcase some of the best 2015 ... Caesars Palace in Las Vegas with a pre-conference session on a collaborative approach ...
(Date:11/27/2015)... , ... November 27, 2015 , ... CBD College ... of Allied Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography program. ... accredited colleges, as only one of twelve colleges and universities in the state of ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 --> ... approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... found that immunotherapy can be efficiently combined with photodynamic ...
(Date:11/26/2015)... SAN FRANCISCO , November 26, 2015 ... 1.82 billion by 2022, according to a new report by ... as Chronic Kidney Disease (CKD) which demands kidney transplantation is ... convenient and cost effective substitute for organ transplantation. --> ... 1.82 billion by 2022, according to a new report by ...
(Date:11/26/2015)... November 26, 2015 ... the "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Country Segment Forecasts, ... their offering. --> ) ... "2016 Future Horizons and Growth Strategies in ...
Breaking Medicine Technology: