Navigation Links
Newfoundland researchers crack the genetic code of a sudden death cardiac killer
Date:10/25/2010

Montreal Researchers in Newfoundland have cracked the genetic code of a sudden death cardiac killer.

As a result, they have developed a unique prevention program in which people with no symptoms, but with a suspect gene and a family history, are being implanted with internal cardiac defibrillators (ICDs) which can restart their hearts if they stop.

"Our discovery has led to a targeted genetic screening and individualized therapy that is significantly improving survival rates," Dr. Sean Connors told the Canadian Cardiovascular Congress 2010, co-hosted by the Heart and Stroke Foundation and the Canadian Cardiovascular Society. "It's allowing people with the condition to live normal, longer lives. Individualized genetic therapies like this are the future of medicine."

The excitement among cardiologists concerns a rare genetic condition arrhythmogenic right ventricular cardiomyopathy (ARVC).

"Newfoundlanders likely have the highest incidence in the world of this disease," Dr. Connors, a cardiologist and associate professor of medicine at Memorial University in Newfoundland, told the Congress.

The term arrhythmogenic refers to deadly cardiac rhythms that can be triggered by electrical impulses within the heart. Cardiomyopathy is a worsening condition where heart muscle is slowly replaced by scar and fat tissue.

The combination of the two is lethal, Dr. Connors says.

"People who are at risk often have no symptoms, so the first time we know they have this disease is when they die."

Genetic profiling?

The surest sign that a disease is genetic in origin is when it is manifests itself in family histories, showing up in generation after generation.

"Our diagnostic testing showed that some members of these families have a specific, genetic, electrocardiogram (ECG) mutation ARVD5," said Dr. Connors. There is a 50 per cent chance that children of those with the condition will also be carriers of the gene. It is considered the second-most common cause of sudden cardiac death in young people.

The mutation causes premature sudden cardiac death in males: 50 per cent die by age 40 years and 80 per cent by 50 years. For women the rate is five per cent and 20 per cent.

Given those figures, Dr. Connors realized nothing would be lost by implanting ICDs in asymptomatic patients with ARVD5 to maintain normal heart rhythms.

Earlier this year his team reviewed the data of the prevention program which they started in 1999. They concluded that implanted defibrillator treatment for primary prevention in both sexes, and secondary prevention in males significantly improves survival.

According to Heart and Stroke Foundation spokesperson Dr. Beth Abramson, there are as many as 40,000 sudden cardiac arrests every year in Canada.

"What's fascinating about this study is that they show that preventive intervention works," says Dr. Abramson. "This treatment is not only prolonging lives; it's giving families peace of mind and hope for the future."

She also notes, "This is exciting information for physicians working with these rare cases but is also important to remember that the most common causes of heart disease relate to lifestyle. It is important that all of us, regardless of family history, take care of our hearts: basic things like smoking cessation, following a healthy diet, and physical activity go a long way in protecting our health."


'/>"/>

Contact: Jane-Diane Frasr
jfraser@hsf.ca
613-569-4361 x273
Heart and Stroke Foundation of Canada
Source:Eurekalert

Related medicine news :

1. Researchers find pathway that drives spread of pediatric bone cancer in preclinical studies
2. Quebec City researchers pave the way for novel treatment of pulmonary hypertension
3. Mount Sinai researchers discover origin of immune cells in the brain
4. UC San Diego researchers identify factor boosting leukemias aggressiveness
5. UCI stem cell researchers to receive $9.35 million in state funding
6. Researchers find better method to help mothers cope with childs cancer and related stress
7. Researchers advocate for more education and attention regarding rare breast cancer
8. Mount Sinai researchers discover why cocaine is so addictive
9. Temperature rhythms keep body clocks in sync, UT Southwestern researchers find
10. Need a study break to refresh? Maybe not, say Stanford researchers
11. Researchers reach consensus on use of deep brain stimulation to treat Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... Buyers and sellers in the ... dispensaries and head shops –can’t help but be heartened by the industry’s current surge. ... odor aptly described as “skunk smell.” At last they can simply, safely and ...
(Date:4/25/2017)... ... April 25, 2017 , ... There is no better place in South ... special report in the May issue of Consumer Reports focused on heart health. ... results achieved during and after coronary bypass and aortic valve replacement procedures. , ...
(Date:4/24/2017)... ... April 24, 2017 , ... LG ... Your Own Device (BYOD) capabilities at Telehealth 2.0, the American Telemedicine Association’s national ... which pairs medical devices with a pre-programmed tablet in a remarkably easy-to-use kit ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... As part ... Museum today to honor the victims of the Holocaust and Nazi persecution, Center ... at Hadamar and Auschwitz on its CMATH Champions trip to Germany and Poland next ...
(Date:4/24/2017)... ... ... The California Dental Association Foundation’s two-day volunteer dental clinic, CDA Cares ... April 22-23 event at the San Mateo Event Center. , In addition to ... Cares educates the public and policymakers about the importance of good oral health and ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 The Global Effective Microorganisms (EM) ... report has covered and analysed the potential of Global Effective ... size, shares and growth factors. The report identifies and analyses ... in the global market. ... Browse 152 Tables and Figures, 6 Major Company Profiles, spread ...
(Date:4/19/2017)... , April 19, 2017 ... an immune response in pets such as canine, ... are of various types such as Attenuated Live ... Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated live ... virus or bacteria, which have been weakend under ...
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
Breaking Medicine Technology: