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Newest cancer therapies multi-task to eliminate tumors
Date:9/16/2011

while higher doses turned it on.

It also may help explain a common cancer vaccine side effect: the immune system's attack on healthy as well as cancerous tissue.

IDO, or indoleomine 2,3-dioxyegenase, locally suppresses immune system action by degrading tryptophan, an amino acid essential to survival of T-cells, orchestrators of immune response. Along with tumors, infectious agents, such as HIV, may use this mechanism to escape the immune system. In addition to pursuing the cancer treatment potential of IDO inhibitors, GHSU researchers have been looking at how invoking IDO can protect transplanted organs or treat autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, respectively.


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Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

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