Navigation Links
Newest cancer therapies multi-task to eliminate tumors
Date:9/16/2011

AUGUSTA, Ga. Some of the newest therapies in the war on cancer remove the brakes cancer puts on the immune system, Georgia Health Sciences University researchers report.

These immunotherapies, such as CTLA4, strengthen the immune system's attack on cancer by keeping apart two proteins that prevent key immune cells called T cells from activating.

Research featured on the cover of the Journal of Immunology suggests that these therapies also keep tumors from benefitting from IDO, an enzyme used by fetuses and tumors alike to suppress the immune response.

"This is an alternative way of avoiding the immune system brakes," said Dr. Andrew Mellor, Director of the GHSU Immunotherapy Center and the study's corresponding author. "These findings give us better insight into how cancer immunotherapy works so in the future we can better minimize the side effects and maximize the effect we want which is anti-tumor."

Mellor and Dr. David Munn, who leads the Cancer Immunotherapy Program in the GHSU Cancer Center and co-authored the study, led a research team that in 1998 identified IDO's role in preventing a mother's immune system from rejecting a fetus. They subsequently learned that tumors pirate the mechanism. The university has patented technologies to inhibit IDO, which are currently in clinical trials funded by the National Cancer Institute and corporate partners. "Tumors are really good at turning on IDO and after the cancer is found it becomes important to turn it off," Mellor said.

The study also provides new insight into cancer treatment vaccines that have worked well in the laboratory but are less successful in patients, Mellor said.

It suggests that the quantity of bacterial mimics, which get the attention of the immune system, is pivotal. Mellor and his colleagues showed in 2005 that the bacterial mimic CpG-ODNs can actually activate IDO. The new study confirmed that a lower dose avoided stimulating IDO while higher doses turned it on.

It also may help explain a common cancer vaccine side effect: the immune system's attack on healthy as well as cancerous tissue.

IDO, or indoleomine 2,3-dioxyegenase, locally suppresses immune system action by degrading tryptophan, an amino acid essential to survival of T-cells, orchestrators of immune response. Along with tumors, infectious agents, such as HIV, may use this mechanism to escape the immune system. In addition to pursuing the cancer treatment potential of IDO inhibitors, GHSU researchers have been looking at how invoking IDO can protect transplanted organs or treat autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, respectively.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Newest screen for newborns will indicate heart problems
2. AACR recognizes its newest grantees at 102nd Annual Meeting 2011
3. California Health Interview Survey releases newest data on state residents health
4. Not Just the Newest Toys Hold Risks for Kids
5. Throwdown, a Leader in Impact and Action Sports, Debuts Latest Innovations at the Newest UFC Gym™ in Rosemead, California
6. Pennsylvania's Newest Power Companies Right in Your Neighbor's Back Yard
7. Java Planet, Tampa Bay's Newest Organic Coffee Company Announces That it Has Become Fair Trade Certified™
8. InBoundMarketingPR: Cord Blood America Newest Inbound Marketing Client
9. Newest Release of FileTrail Sets New Standard in Global Physical Records Management and File Tracking
10. The Newest Concept in Knife Sharpening
11. Announcing the Newest and Most Anticipated Product of the Year: Coming Feb 24th
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newest cancer therapies multi-task to eliminate tumors
(Date:2/12/2016)... ... February 12, 2016 , ... The aging population and ... long term care. With that, says Patrick Loughney, president of Longtree & ... in long term care environments. His company, which offers prep courses and workshops ...
(Date:2/12/2016)... ... February 12, 2016 , ... Dignity Health named Dr. Scott Bingham the ... The new facility is licensed under Dignity Health Arizona General Hospital , ... excellent leader and will ensure our new freestanding emergency room delivers the highest quality ...
(Date:2/11/2016)... ... 2016 , ... Student-doctors from Western University of Health Sciences’ ... February 9, taking one of the final steps in their medical school career. ... the country. Of the 103 student-doctors who comprise the College of Osteopathic Medicine ...
(Date:2/11/2016)... , ... February 11, 2016 , ... Image One ... to a new market, and it’s the buildings of Nashville that will benefit. , ... I needed to relocate to Nashville, there was no question that I would bring ...
(Date:2/11/2016)... ... February 11, 2016 , ... Thermi™, a world leader in ... announce the promotions of Allison Kelly to executive vice president of the company’s ... president of North American capital sales, and Wendy Oseas to vice president of ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Calif. , Feb. 11, 2016  Walgreens has ... across 39 states and Washington, D.C. ... a move that was commended by shareholder advocacy organization As ... at As You Sow. "Many people hold on to unneeded ... which can have tragic consequences." --> Conrad ...
(Date:2/11/2016)...  MiMedx Group, Inc. (NASDAQ: MDXG ), the ... other birth tissues, human skin and bone, and patent-protected ... products and therapies, announced today that it will present ... in New York , NY.  Parker ... Senken , Chief Financial Officer and Chris Cashman ...
(Date:2/11/2016)... fevereiro de 2016  A Proliant Biologicals anuncia, ... soroalbumina bovina (BSA -- Bovine Serum Albumin ... Ilha Norte da Nova Zelândia, em Feilding. ... fábrica da Proliant nos EUA, localizada em ... instalação dos equipamentos foram feitos de forma a ...
Breaking Medicine Technology: