Navigation Links
Newest cancer therapies multi-task to eliminate tumors

AUGUSTA, Ga. Some of the newest therapies in the war on cancer remove the brakes cancer puts on the immune system, Georgia Health Sciences University researchers report.

These immunotherapies, such as CTLA4, strengthen the immune system's attack on cancer by keeping apart two proteins that prevent key immune cells called T cells from activating.

Research featured on the cover of the Journal of Immunology suggests that these therapies also keep tumors from benefitting from IDO, an enzyme used by fetuses and tumors alike to suppress the immune response.

"This is an alternative way of avoiding the immune system brakes," said Dr. Andrew Mellor, Director of the GHSU Immunotherapy Center and the study's corresponding author. "These findings give us better insight into how cancer immunotherapy works so in the future we can better minimize the side effects and maximize the effect we want which is anti-tumor."

Mellor and Dr. David Munn, who leads the Cancer Immunotherapy Program in the GHSU Cancer Center and co-authored the study, led a research team that in 1998 identified IDO's role in preventing a mother's immune system from rejecting a fetus. They subsequently learned that tumors pirate the mechanism. The university has patented technologies to inhibit IDO, which are currently in clinical trials funded by the National Cancer Institute and corporate partners. "Tumors are really good at turning on IDO and after the cancer is found it becomes important to turn it off," Mellor said.

The study also provides new insight into cancer treatment vaccines that have worked well in the laboratory but are less successful in patients, Mellor said.

It suggests that the quantity of bacterial mimics, which get the attention of the immune system, is pivotal. Mellor and his colleagues showed in 2005 that the bacterial mimic CpG-ODNs can actually activate IDO. The new study confirmed that a lower dose avoided stimulating IDO while higher doses turned it on.

It also may help explain a common cancer vaccine side effect: the immune system's attack on healthy as well as cancerous tissue.

IDO, or indoleomine 2,3-dioxyegenase, locally suppresses immune system action by degrading tryptophan, an amino acid essential to survival of T-cells, orchestrators of immune response. Along with tumors, infectious agents, such as HIV, may use this mechanism to escape the immune system. In addition to pursuing the cancer treatment potential of IDO inhibitors, GHSU researchers have been looking at how invoking IDO can protect transplanted organs or treat autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, respectively.


Contact: Toni Baker
Georgia Health Sciences University

Related medicine news :

1. Newest screen for newborns will indicate heart problems
2. AACR recognizes its newest grantees at 102nd Annual Meeting 2011
3. California Health Interview Survey releases newest data on state residents health
4. Not Just the Newest Toys Hold Risks for Kids
5. Throwdown, a Leader in Impact and Action Sports, Debuts Latest Innovations at the Newest UFC Gym™ in Rosemead, California
6. Pennsylvania's Newest Power Companies Right in Your Neighbor's Back Yard
7. Java Planet, Tampa Bay's Newest Organic Coffee Company Announces That it Has Become Fair Trade Certified™
8. InBoundMarketingPR: Cord Blood America Newest Inbound Marketing Client
9. Newest Release of FileTrail Sets New Standard in Global Physical Records Management and File Tracking
10. The Newest Concept in Knife Sharpening
11. Announcing the Newest and Most Anticipated Product of the Year: Coming Feb 24th
Post Your Comments:
Related Image:
Newest cancer therapies multi-task to eliminate tumors
(Date:10/12/2015)... Carolina (PRWEB) , ... October 12, 2015 , ... Kevin Costello, winner of the “Check-In ... Carolina , embarks today for his dream vacation to Hawaii. , “I didn’t believe I ... out,” he says. “This contest encouraged me to get to the gym and invest in ...
(Date:10/12/2015)... ... October 12, 2015 , ... Amerec , a ... of spa and skin care equipment, will be displaying custom sauna and steam room ... With many high-end resorts and spas as customers, SpaEquip is recognized for their ability ...
(Date:10/12/2015)... ... October 12, 2015 , ... The ... by individuals who lack professional education and clinical training in a health care ... a variety of purposes such as: losing weight, managing pain, or stopping smoking, ...
(Date:10/12/2015)... ... ... American Family Care (AFC), the nation’s leading provider of urgent care and ... Located at 606A Boll Weevil Circle in Enterprise, it is the company’s ninth location ... quality health care accessible and economical with the opening of our medical center in ...
(Date:10/12/2015)... ... 12, 2015 , ... At first glance, it looks like a mini parachute ... a drink in a tiki bar. But the Parachute® Ventricular Partitioning Device being implanted ... (AGH) could potentially signal a new way of treating people with heart failure. , ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... Oct. 12, 2015 A new computer program ... can predict whether they will develop effective language skills ... a study in the journal Brain and Behavior ... In the journal,s Oct. 12 online edition, researchers ... program determines how specific regions of the brain respond ...
(Date:10/12/2015)... Oct. 12 2015 ... of the "Personalized Medicine, Targeted Therapeutics ... Strategic Analysis of Industry Trends, Technologies, Participants, ... --> ) has announced ... Targeted Therapeutics and Companion Diagnostic Market to ...
(Date:10/12/2015)... , Oct. 12, 2015  Edwards Lifesciences Corporation (NYSE: ... valves and hemodynamic monitoring, plans to announce its operating results ... closes on Monday, October 26, 2015, and will host a ... those results. . A live stream and ... downloading Edwards, IR App for iPhone and iPad ...
Breaking Medicine Technology: