Navigation Links
Newest Diabetes Drugs Linked to Higher Pancreatitis Risk

MONDAY, Feb. 25 (HealthDay News) -- Diabetes patients who take the latest class of drugs to control blood sugar levels are twice as likely to develop pancreatitis as those who take other medications to control blood sugar, according to a new study.

The drugs Januvia (sitagliptin) and Byetta (exenatide) are glucagon-like peptide-1-based (GLP-1) therapies, which are used by millions of Americans with diabetes.

Pancreatitis is inflammation of the pancreas, the organ that releases hormones such as insulin and glucagon, as well as enzymes that help digest food. Pancreatitis is a painful condition that can be dangerous if left untreated. People with diabetes are already at higher risk for pancreatitis because of the role the pancreas plays in the condition.

In this study, researchers from Johns Hopkins University in Baltimore compared nearly 1,300 type 2 diabetes patients who took one of the GLP-1 drugs with the same number of type 2 diabetes patients who took other medications. Those who took the GLP-1 drugs were twice as likely to be hospitalized with acute pancreatitis within 60 days of first taking the drugs than the other group of patients.

The GLP-1 drugs appeared to affect the pancreas in ways that trigger inflammation, according to the study, which was published online Feb. 25 in the journal JAMA Internal Medicine.

Doctors and government regulators have known that pancreatitis could be a side effect of GLP-1 drugs, a risk that was noted in animal studies and reported to the U.S. Food and Drug Administration. The researchers said their study is the first to accurately assess the degree of risk in humans. While their findings showed an association between the drugs and pancreatitis, they did not prove a cause-and-effect link.

"These agents are used by millions of Americans with diabetes. These new diabetes drugs are very effective in lowering blood glucose," study leader Dr. Sonal Singh, an assistant professor in the division of general internal medicine at the Johns Hopkins University School of Medicine, said in a university news release. "However, important safety findings may not have been fully explored, and some side effects such as acute pancreatitis don't appear until widespread use after approval."

Patients taking GLP-1 drugs should know about the symptoms of pancreatitis -- abdominal pain, nausea and persistent vomiting -- and seek immediate treatment if these symptoms occur, the researchers said.

Another expert added some additional caveats.

"Physicians need to be aware of these problems and discuss risks versus benefits with their patients," said Dr. Abayomi Akanji, a professor in medical sciences at the Frank H. Netter MD School of Medicine at Quinnipiac University, in Connecticut. "Of course, these drugs are not recommended to be prescribed to children, pregnant women and maybe nursing mothers. They should also preferably be avoided in individuals with poor liver or kidney function, or who are hypersensitive to the medication."

"Physicians should specifically review with patients their past and current medical history for evidence of susceptibility to pancreatic or thyroid disease, and avoid use in individuals with such a history," Akanji added.

But a second expert said most diabetes drugs carry some risk for adverse reactions.

"While there have been previous reports that have associated these medications with pancreatitis, this study increases the evidence for a link between the medications and pancreatitis," said Dr. Jeffrey Powell, chief of the division of endocrinology at Northern Westchester Hospital in Mount Kisco, N.Y. "However, patients should realize that most diabetes medications can have significant adverse effects."

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about pancreatitis.

-- Robert Preidt

SOURCES: Abayomi Akanji, M.D., professor, medical sciences, Frank H. Netter MD School of Medicine, Quinnipiac University, Connecticut; Jeffrey Powell, M.D., chief, division of endocrinology, Northern Westchester Hospital, Mount Kisco, N.Y.; Johns Hopkins School of Medicine, news release, Feb. 25, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New - Renaissance Age Serum, a Revival in Swiss Anti-Aging Skin Care; Improve Skin Texture for a More Youthful Appearance using Gerda Spillmann’s Newest Anti-Aging Serum
2. Caribbean Hideaways / Go Classy Tours Announces the Launch of Their Newest Website the Premier all Nude, Nudist Resort in Mexico
3. Brightwater Senior Living of Stonebridge, Saskatoon's Newest Personal Care and Memory Care, Is Proud To Sponsor The Alzheimer Society of Saskatchewan's Walk For Memories
4. Launches All-New Website for Its Newest Product
5. To Promote It's Newest Xoçai™ Product, Xe Healthy Energy Drink, Marketing Xocolate International Corporation (MXI Corp) Launches Contest, Offers FJ Cruiser As Grand Prize
6. Naturel Collagen Canada Unveils C RUM, the Newest Addition to the Revolutionary Natural Collagen Skin Care Product Line
7. K9 CarFence™ Launches as Newest Innovation in Pet Transportation
8. Reprogramming cells to fight diabetes
9. 1 in 8 Americans Diagnosed With Type 2 Diabetes: Poll
10. Independent panel to present findings on diagnosing gestational diabetes mellitus
11. US Drug Watchdog Now Urges Families Of Diabetics Who Developed Bladder Cancer After Using The Diabetes Drug Called To Call The Johnson Law Group-For A Legal Review
Post Your Comments:
Related Image:
Newest Diabetes Drugs Linked to Higher Pancreatitis Risk
(Date:11/25/2015)... Indianapolis, IN (PRWEB) , ... November 25, 2015 ... ... clean water accessible for all, Water For Empowerment ™ attracts volunteers together ... on clean water by empowering women as key stakeholders in the process. The ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director ... about hair loss treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for ... and fuller hair, without the need for surgery, prescription pills, or topical foams. ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... people across the country to celebrate their sobriety and show through pictures what ... “before and after” photos this Thanksgiving with the hashtag #FacesOfGratitude on their Facebook, ...
(Date:11/25/2015)... ... 2015 , ... On November 23rd 2015 Cozy Products, a division ... business. Cozy Products explains what this means for business moving forward. , The Tri ... Products business model: to sell personal heaters that reduce energy consumption, are economical and ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study conducted by ... Chicago, IL, UV Angel is evaluating the efficacy of its product and its disinfection ... (totaling 30 beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... --> --> Juntendo University ... contrast weighting of MRI for patients with Multiple Sclerosis ... agreement with SyntheticMR in order to use SyMRI in clinical ... to generate multiple contrast images from a single scan and ... making it possible to both fine tune images and recreate ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ( ... "Advanced Wound Care Market by Type (Dressings, Therapy Devices, ... (In-Patient Facility, Out-Patient Facility), and Geography - Global Forecast ... --> --> The purpose ... and forecast of the global advanced wound care market. ...
Breaking Medicine Technology: