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Newest Diabetes Drugs Linked to Higher Pancreatitis Risk
Date:2/25/2013

MONDAY, Feb. 25 (HealthDay News) -- Diabetes patients who take the latest class of drugs to control blood sugar levels are twice as likely to develop pancreatitis as those who take other medications to control blood sugar, according to a new study.

The drugs Januvia (sitagliptin) and Byetta (exenatide) are glucagon-like peptide-1-based (GLP-1) therapies, which are used by millions of Americans with diabetes.

Pancreatitis is inflammation of the pancreas, the organ that releases hormones such as insulin and glucagon, as well as enzymes that help digest food. Pancreatitis is a painful condition that can be dangerous if left untreated. People with diabetes are already at higher risk for pancreatitis because of the role the pancreas plays in the condition.

In this study, researchers from Johns Hopkins University in Baltimore compared nearly 1,300 type 2 diabetes patients who took one of the GLP-1 drugs with the same number of type 2 diabetes patients who took other medications. Those who took the GLP-1 drugs were twice as likely to be hospitalized with acute pancreatitis within 60 days of first taking the drugs than the other group of patients.

The GLP-1 drugs appeared to affect the pancreas in ways that trigger inflammation, according to the study, which was published online Feb. 25 in the journal JAMA Internal Medicine.

Doctors and government regulators have known that pancreatitis could be a side effect of GLP-1 drugs, a risk that was noted in animal studies and reported to the U.S. Food and Drug Administration. The researchers said their study is the first to accurately assess the degree of risk in humans. While their findings showed an association between the drugs and pancreatitis, they did not prove a cause-and-effect link.

"These agents are used by millions of Americans with diabetes. These new diabetes drugs are very effective in lowering blood glucose," study leader Dr. Sonal Singh, an assi
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