Navigation Links
Newer antimalarials more effective than quinine against severe malaria
Date:3/15/2011

Quinine should no longer be the drug of choice for treating severe malaria, according to an updated systematic review by Cochrane researchers. It is now evident that the antimalarial drug artesunate, which is derived from herbs used in Chinese medicine, is more effective at preventing death in patients with severe malaria.

Severe malaria occurs when the disease affects the function of vital organs. It is associated with rarer cerebral malaria, which affects the brain and can lead to long-term disability. More than a million people die each year from severe malaria, the majority in Sub-Saharan Africa. Artesunate was recommended as the preferred treatment for adults with severe malaria by the World Health Organization (WHO) in 2006, but there was insufficient evidence at the time to recommend a change from the standard treatment of quinine in children.

The researchers updated the review of artesunate by adding a new large multicentre trial of African children published in the Lancet in 2010 to the existing 8 trials. The review now includes a total of 1664 adults and 5765 children, from a variety of settings across Africa and Asia. According to the results, taking artesunate reduces the risk of death by 39% in adults and 24% in children compared to quinine. In adults, deaths caused by severe malaria were reduced from 241 per 1000 with quinine to 147 with artesunate. In children, deaths were reduced from 108 per 1000 with quinine to 83 with artesunate.

"There is now enough evidence to be confident of these results in adults and children," said Peter Olumese of the WHO's Global Malaria Programme. "Intravenous artesunate is now being recommended as the treatment of choice for adults and children with severe malaria anywhere in the world."

Although more children given artesunate suffered neurological problems compared to those given quinine, these were largely resolved within a month of treatment, and were outweighed by the increase in survival rates. "The balance of benefits and harms is in favour of treatment with artesunate," said David Sinclair of the Liverpool School of Tropical Medicine in Liverpool, UK, who led the review team.


'/>"/>

Contact: Jennifer Beal
healthnews@wiley.com
44-012-437-70633
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Research shows rapid adoption of newer, more expensive prostate cancer treatments
2. Newer Drug May Help Prevent Fracture in Men With Prostate Cancer
3. Newer, more intense chemotherapy with less radiation not more effective against Hodgkins lymphoma
4. Decrease in suicide not linked to newer antidepressants
5. Newer Drugs Beat Gleevec in Head-to-Head Trials
6. In infant heart surgery, newer technique yields better survival in first year of life
7. Newer Genetic Info Adds Little to Predicting Breast Cancer
8. Newer Blood Thinner Beats Plavix for Bypass Patients
9. Newer Genetic Test for Autism More Effective
10. Newer Blood Test Predicts Diabetes, Heart Disease
11. Newer cornea transplant surgery shows short- and long-term promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... ... The Journal of Pain Research has published the commentary “ Terminology ... author Dr John F. Peppin says “Terminology matters, yet little attention has been paid ... ‘Chronic cancer pain’ and ‘chronic non-cancer pain’ are replete in the literature; however, the ...
(Date:2/9/2016)... ... February 09, 2016 , ... ZipHearing.com is ... to affordable hearing aids , increase industry transparency, and promote awareness of ... States. , “For the average consumer, the hearing aid industry is esoteric and ...
(Date:2/9/2016)... ... ... Two renowned photographers, Robert Caplin (New York, NY) and Peter Lockley (Denver, ... 2016, hosted by Four Seasons Resort Maui at Wailea as part of the luxury ... the Maui Photo Expedition workshop will once again consist of on-location shoots, ...
(Date:2/9/2016)... ... 09, 2016 , ... i2i Systems, an early innovator and developer of population ... the latest KLAS report, Population Health Management 2015: How Far Can Your Vendor Take ... health management (PHM). The latest KLAS Report, leveraging over 200 user interviews, shines ...
(Date:2/8/2016)... ... , ... CURE Media Group , the nation’s leading digital and print ... Awards event , which will annually honor individuals making heroic contributions in the field ... MM Heroes Awards nomination process is officially open through February 17 for patients, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... LONDON , Feb. 9, 2016 The ... in 2014, and it is expected to grow with ... types, the glass prefilled syringes segment dominated the global ... --> --> The global ... significant rate, due to increasing geriatric population, increasing demand ...
(Date:2/9/2016)... , Feb. 9, 2016 The new report "Global Blood Monitoring ... Acuity Business Research & Consulting group reveals that global market for ... million in 2014 and expected to grow to US$ 24,830.1 million ... North America , Europe ... , Middle-East and Africa ...
(Date:2/9/2016)... 9, 2016  Increasingly, health care professionals are enhancing ... with wireless technology. With the Vios Monitoring System from ... and remotely detect problems before they become serious by ... environments. the United States . ... . --> The Vios Monitoring System ...
Breaking Medicine Technology: