Navigation Links
Newer Genetic Info Adds Little to Predicting Breast Cancer
Date:3/17/2010

Data on lesser known variants didn't improve powers of standard risk model

WEDNESDAY, March 17 (HealthDay News) -- Plugging certain genetic data into the standard risk-assessment model for breast cancer won't do much to help gauge a woman's odds for getting the disease, a new study shows.

Assessing a woman's breast cancer risk remains a work in progress for doctors. For years, experts have relied on what's known as the "Gail model," which asks women seven questions related to family history, medical history and other areas, and then predicts her risk for breast cancer.

Experts have also known that women with mutations in the BRCA1 and BRCA2 genes are at much higher breast cancer risk than women without these mutations.

But more recently, scientists have identified several other genetic variants linked with breast cancer.

So, in a study published in the March 18 issue of the New England Journal of Medicine, researchers decided to add these newer variants to the model and see if it could improve prediction of risk over and above the standard Gail model.

"These variants are common," noted study co-author Dr. Patricia Hartge, senior scientist and deputy director of epidemiology and biostatistics at the U.S. National Cancer Institute. The variants are known as SNPs -- single nucleotide polymorphisms.

They're not as powerful, however, as the much-cited BRCA1 and BRCA2 gene mutations, Hartge said, and each SNP boosts a woman's risk much less than the BRCA genes might.

In the study, Hartge and her colleagues evaluated information on both traditional risk factors -- such as those assessed by the Gail model and 10 common SNP genetic variants, deriving information and genetic data from four large U.S.-based studies and one large Polish breast cancer study. Women in the studies ranged in age from 50 to 79.

In all, almost 5,600 women from the studies had breast cance
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Newer antidepressants led to less, not more, teen suicides
2. Newer Antibiotic Speeds TB Healing
3. Newer radiation treatment easier for some throat cancer patients
4. Newer Anticlotting Drug Safe, Effective for Heart Surgeries
5. Newer Sedative Might Help Patients on Ventilators
6. Newer Rheumatoid Arthritis Drugs Lower Production of B Cells
7. Newer Prostate Cancer Treatment Similar to Traditional Surgery
8. Newer Blood Pressure Drug No Better Than Placebo in Preventing Stroke
9. Newer Blood Pressure Drug Better for Some Heart Patients, Diabetics
10. First generation antipsychotic drugs as effective as newer ones in some children
11. Newer antipsychotics no better than older drug in treating child and adolescent schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 Millennium Treatment Group is ... for Florida Mental Health Counselors Association (FMHCA). The addiction ... sponsorship is sure to provide. , FMHCA is an ... Florida’s licensed mental health counselors. The organization was founded ... Association (ACA) and since then, it has served the ...
(Date:8/27/2014)... NY (PRWEB) August 27, 2014 The ... Team ) is holding free events about “ Sexuality ... speaker Liz Treston. These straightforward and entertaining discussions are ... at Bussani Mobility (501 Concord Avenue, Mamaroneck, NY) and ... Central Avenue, Bethpage, NY). , The New York ...
(Date:8/27/2014)... Spring, Md. (PRWEB) August 27, 2014 ... (CHEST) recently released guidelines for the management and ... Pharmacological Therapy for Pulmonary Arterial Hypertension in Adults: ... are free to view for clinicians, and provide ... PAH. , The Pulmonary Hypertension Association ...
(Date:8/27/2014)... Dennis Thompson HealthDay Reporter ... has been mugged in a dark alley will likely never ... fear of being attacked. But neuroscientists working with mice ... are linked with positive and negative emotions. And in rodent ... to a memory. In essence, they made once-reluctant mice ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Michigan Head & ... the children of a local elementary school by ensuring they ... Elementary School has year-round attendance, and Michigan Head & Neck ... meet the new school year. , "There are a lot ... is a great way to give back to our community," ...
Breaking Medicine News(10 mins):Health News:Millennium Treatment Group Sponsors Florida Mental Health Counselors Association 2Health News:Bussani Mobility Sponsors New York Mobility Club Meetings September 9 & October 7 for People with Disabilities, Sexuality & Intimacy Discussed by Advocate Liz Treston 2Health News:Pulmonary Hypertension Association Endorses CHEST Guidelines for Treatment of Pulmonary Arterial Hypertension in Adults 2Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3Health News:Michigan Head & Neck Institute is Conducting Their 2nd Annual School Supplies Drive at Their Facility to Benefit Local Year-Round Elementary School Students 2
... 20 (HealthDay News) -- Most Americans consume too much sodium, ... the amount of dietary salt, according to a new study ... are associated with increased risk of high blood pressure, which ... In general, people aged 2 years and older should limit ...
... 20 (HealthDay News) --,Hospital programs to lessen the overuse ... costs, but too few hospitals have fully implemented such ... -- intended to prevent antibiotic resistance -- for acute ... 2007 by the Infectious Diseases Society of America (IDSA) ...
... UCLA have found a possible explanation for why autistic children ... time, they,ve shown that the connections between brain regions that ... slowly in boys with autism than in non-autistic children. ... journal Human Brain Mapping, senior author Jennifer G. ...
... at NYU Langone Medical Center today announce findings published ... that show for the first time the inhibition of ... oligonucleotides markedly suppress triglyceride levels and cause a sustained ... "The discovery of microRNAs in the last ...
... , THURSDAY, Oct. 20 (HealthDay News) -- The key ... skills and more about controlling negative emotions that make ... suggests. The study found that activation of brain ... math anxiety conquer their fears and succeed in math. ...
... Hospital of Rhode Island has been selected by the National ... Floor Disorders Network (PFDN). Women & Infants is one ... the only one in the Northeast, to work collaboratively to ... floor disorders. Co-principal investigators at Women & Infants are ...
Cached Medicine News:Health News:U.S. Diet Still Has Too Much Salt, CDC Warns 2Health News:Hospital Programs to Reduce Antibiotic Resistance Working: Studies 2Health News:Hospital Programs to Reduce Antibiotic Resistance Working: Studies 3Health News:Autistic brains develop more slowly than healthy brains UCLA researchers say 2Health News:Autistic brains develop more slowly than healthy brains UCLA researchers say 3Health News:Novel therapeutic target identified to decrease triglycerides and increase 'good' cholesterol 2Health News:Afraid to Do the Math? 2
(Date:8/27/2014)... , Aug. 27, 2014  Hill-Rom Holdings, Inc. ... to a management presentation at the Morgan Stanley Global ... EDT. You are invited to listen to ... http://ir.hill-rom.com/events.cfm or access it directly at http://cc.talkpoint.com/morg007/090814a_ac/?entity=26_7CLOGQP ... available one hour after conclusion of the live event ...
(Date:8/27/2014)... , Aug. 27, 2014 Sihuan ... or the "Company"), a leading pharmaceutical company with ... China,s prescription drug market, ... Company and its subsidiaries (collectively the "Group") for ... "Period"). Financial HighlightsFor the Six months ...
(Date:8/27/2014)... Aug. 27, 2014  CVS Caremark (NYSE: ... new clinical affiliation with MedStar Health, a leading health ... and the Washington, DC ... health care services for patients. Through this clinical affiliation, ... clinical support, medication counseling, chronic disease monitoring and wellness ...
Breaking Medicine Technology:Sihuan Pharmaceutical Announces 2014 Interim Results 2Sihuan Pharmaceutical Announces 2014 Interim Results 3Sihuan Pharmaceutical Announces 2014 Interim Results 4Sihuan Pharmaceutical Announces 2014 Interim Results 5Sihuan Pharmaceutical Announces 2014 Interim Results 6Sihuan Pharmaceutical Announces 2014 Interim Results 7CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3
... PALO ALTO, Calif., Feb. 22, 2011 Telik, Inc. (Nasdaq: ... $0.18 per share, for the three months ended December 31, 2010, ... share, for the comparable period in 2009.  For the year ended ... share, compared with a net loss of $23.7 million, or $0.44 ...
... 2011 drugstore.com, inc. (Nasdaq: DSCM ... clinical skincare, and vision products, today announced that ... upcoming events with the financial community: ... & Telecom Conference Date: February 28, 2011Time: 3:20 ...
Cached Medicine Technology:Telik Announces Fourth Quarter and 2010 Year End Financial Results and 2011 Financial Guidance 2Telik Announces Fourth Quarter and 2010 Year End Financial Results and 2011 Financial Guidance 3Telik Announces Fourth Quarter and 2010 Year End Financial Results and 2011 Financial Guidance 4Telik Announces Fourth Quarter and 2010 Year End Financial Results and 2011 Financial Guidance 5drugstore.com to Present at Upcoming Financial Conferences 2
... These Low Contrast Flip charts contain 5 pages ... on each page. Optotype size is 9.5M. Contrast ... These flip charts can be used at several ... the same test. Each offers a different ...
Directional `E' and `C' test....
9" X 14" translucent plastic may be used with illuminated test cabinet or as a wall chart 20/200 to 20/15....
... high-performance recording unit suitable for a wide ... require up to 16 input channels. Examples ... The unit is capable of recording at ... per second continuously to disk, and is ...
Medicine Products: