Navigation Links
Newer Drug Seems Better at Controlling Lupus Kidney Complication
Date:11/16/2011

By Serena Gordon
HealthDay Reporter

WEDNESDAY, Nov. 16 (HealthDay News) -- A newer immune-suppressing drug called mycophenolate mofetil (CellCept) is better at controlling a serious kidney complication from lupus than another commonly used therapy, a new study suggests.

People taking mycophenolate were about half as likely to progress to treatment failure as were people taking azathioprine (Imuran), according to the researchers.

"This study was looking at maintenance therapy for people with lupus nephritis. Was the older drug azathioprine similar or better to the newer drug mycophenolate mofetil [MMF]? We found that MMF was better overwhelmingly," said study author Dr. Mary Anne Dooley, an associate professor of medicine at the University of North Carolina at Chapel Hill.

"There were fewer flares of recurrent nephritis in the group receiving MMF, and more people on MMF went into complete remission. All of the parameters we looked at were going in the same direction," she said.

Results of the study are published in the Nov. 17 issue of the New England Journal of Medicine.

Systemic lupus erythematosus, or lupus, is an autoimmune disease that can cause problems in many areas of the body, including the kidneys. When lupus affects the kidneys, it's called lupus nephritis.

"Lupus nephritis is one of the more serious consequences of lupus. It's associated with significantly increased morbidity and mortality," explained Dr. Cynthia Aranow, an investigator at the Feinstein Institute for Medical Research in Manhasset, N.Y.

Because lupus is an autoimmune disease, healthy cells are mistakenly destroyed by the body's immune system. So, drugs that suppress the immune system dampen the attack on healthy cells, and are the main treatment currently available for lupus nephritis. The drugs are administered in a similar manner to the way they're used for suppressing the immune system after an organ transplant. The initial phase of treatment includes stronger medicines or stronger doses to induce a remission. Once a remission is induced, patients are switched to maintenance therapy.

And, that's what the current study was designed to assess. It included 227 people with lupus nephritis, ranging in age from 12 to 75 years old. One hundred and sixteen were randomly assigned to maintenance treatment with mycophenolate mofetil and 111 were assigned to receive azathioprine.

Aranow explained that lupus nephritis is classified as an "orphan disease," a term used to describe diseases that affect only small numbers of individuals, which makes getting large numbers of people into clinical trials very difficult.

The researchers found that treatment failure occurred in 32.4 percent of people who were taking azathioprine versus 16.4 percent of those taking mycophenolate mofetil. Flare-ups of kidney disease activity occurred in 23.4 percent of those taking azathioprine and 12.9 percent of those on mycophenolate mofetil, according to the study.

Both groups had significant side effects, including minor infections and gastrointestinal disorders. But, serious adverse events were more common in people taking azathioprine compared to those on mycophenolate -- 33.3 percent versus 23.5 percent, respectively.

The study was initially funded by Aspreva Pharmaceuticals, in collaboration with Roche Pharmaceuticals. Roche produces CellCept, which is U.S. Food and Drug Administration-approved for people who've had an organ transplant. Aspreva's agreement with Roche allowed them to seek approval of CellCept specifically for the treatment of lupus nephritis, according to Dooley. During the course of the study, Aspreva went out of business and was acquired by Vifor Pharmaceuticals. Vifor continued funding the study.

Dooley said that right now mycophenolate mofetil is only available as CellCept, and is more expensive than azathioprine. But, she added, it will soon be generic, which should bring the cost closer to azathioprine.

Aranow said this study shows that "progress is being made, and the prognosis for people with lupus nephritis is better than it was years ago. From this study, it appears that CellCept has a slight superiority over Imuran for keeping lupus nephritis in remission."

More information

Learn more about lupus nephritis from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.

SOURCES: Mary Anne Dooley, M.D., M.P.H., associate professor, medicine, University of North Carolina, Chapel Hill; Cynthia Aranow, M.D., investigator, Feinstein Institute for Medical Research, Manhasset, N.Y.; Nov. 17, 2011, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Newer cornea transplant surgery shows short- and long-term promise
2. Newer Blood Test Predicts Diabetes, Heart Disease
3. Newer Genetic Test for Autism More Effective
4. Newer Blood Thinner Beats Plavix for Bypass Patients
5. Newer Genetic Info Adds Little to Predicting Breast Cancer
6. In infant heart surgery, newer technique yields better survival in first year of life
7. Newer Drugs Beat Gleevec in Head-to-Head Trials
8. Decrease in suicide not linked to newer antidepressants
9. Newer, more intense chemotherapy with less radiation not more effective against Hodgkins lymphoma
10. Newer Drug May Help Prevent Fracture in Men With Prostate Cancer
11. Research shows rapid adoption of newer, more expensive prostate cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newer Drug Seems Better at Controlling Lupus Kidney Complication
(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California and its ... cancer. , Gary D. Radine, who recently retired as president and CEO of Delta ... 2015 CEO of the Year , helped lead the effort to raise funds ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating ... a significant number of women and men with eating disorders report a history ... best predicts the development of an eating disorder. , At the 2016 ...
(Date:2/8/2016)... ... February 08, 2016 , ... GrassrootsHealth published data from ... type 2 diabetes in the GrassrootsHealth cohort with substantially higher vitamin D levels ... in public health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety and ...
(Date:2/8/2016)... ... February 08, 2016 , ... Joshua Rosenthal, PhD, Chief Scientific ... can use newly released government data on populations and physicians to better calculate ... capture the value they create to succeed in new economic models for value ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... only four states in the U.S. require dental technicians to be certified or ... the dental industry, NADL created the “What’s In Your Mouth?” campaign to inform ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... Feb. 9, 2016 The global prefilled syringes ... it is expected to grow with a CAGR of ... prefilled syringes segment dominated the global prefilled syringes market, ... --> The global market of prefilled ... to increasing geriatric population, increasing demand for vaccines, increasing ...
(Date:2/9/2016)...  Increasingly, health care professionals are enhancing patient care ... technology. With the Vios Monitoring System from Vios Medical, ... detect problems before they become serious by continuously tracking ... the United States . ... --> The Vios Monitoring System connects patient-worn ...
(Date:2/9/2016)... KONG , Feb. 9, 2016 Athenex, Inc. ... Athenex as Vice President of Corporate Strategy and Business Development ... MSc, MBA has joined as Senior Director and Deputy Head of Clinical ... . Simon Pedder stated, "Athenex has ... for a while. Coupled together with their unique business model ...
Breaking Medicine Technology: