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Newer Drug Beats Tamoxifen for Older Breast Cancer Patients
Date:8/19/2009

er Center in New York City, said the study shows no advantage in starting women on tamoxifen and then switching them to letrozole.

"For postmenopausal people, it becomes clearer and clearer that the treatment of choice is an aromatase inhibitor without the use of tamoxifen," Norton said. "The window of opportunity for tamoxifen is narrowed by this paper."

"For most patients who are postmenopausal, I use an aromatase inhibitor exclusively," Norton added. "But I have used tamoxifen in postmenopausal patients for specific situations, such as extremity fragile bones, or such as intolerance of the aromatase inhibitor."

More information

There's more on breast cancer at the American Cancer Society.



SOURCES: Alan Coates, M.D., co-chair, scientific committee, International Breast Cancer Study Group, and clinical professor, School of Public Health, University of Sydney, Australia; Larry Norton, M.D., deputy physician-in-chief, Breast Cancer Programs, Memorial Sloan-Kettering Cancer Center, New York City; Victor Vogel, M.D., M.H.S., national vice president, research, American Cancer Society; Aug. 20, 2009, New England Journal of Medicine


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