Navigation Links
Newer, more intense chemotherapy with less radiation not more effective against Hodgkin's lymphoma

A lower dose of radiation used to reduce side effects is not as effective as the regular dose when given with the standard chemotherapy in the treatment of Hodgkin's lymphoma patients with early, intermediate-stage disease, according to a first-of-its-kind randomized study presented at the plenary session, November 1, 2010, at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO).

In addition, the trial showed that a more intensive chemotherapy (BEACOPP) is not more effective than the standard chemotherapy treatment (ABVD) for these patients.

"This confirms that four cycles of ABVD, followed by 30 Gy involved field radiation therapy, should continue to be the standard treatment for early intermediate-stage Hodgkin's lymphoma patients," Hans Theodor Eich, M.D., Ph.D. lead author of the study and a radiation oncologist at the University of Cologne, in Cologne, Germany, said. "Prior to the study, it was unclear what the optimal chemotherapy regimen and the most effective dose of radiation was."

Chemotherapy followed by radiation treatment is the standard treatment for intermediate-stage Hodgkin's lymphoma. This group of patients has the disease in one or more lymph nodes on the same side of the diaphragm (the muscle under the lungs), along with other factors associated with a higher risk of the cancer spreading to other parts of the body.

Fortunately, cure rates among these Hodgkin's lymphomas, even those considered "unfavorable" as studied here, is very high. That is why doctors continue to experiment with treatment to maximize the chances for a cure while limiting the risks of long-term side effects.

This randomized study sought to determine the most effective dose of radiation for some Hodgkin's lymphoma patients. Researchers also examined whether a more intensive form of chemotherapy would improve the risk of cancer spreading, compared to the standard chemotherapy regime.

Between 1998 and 2003, 1,395 patients with untreated, early unfavorable Hodgkin's lymphoma were randomized into one of four treatment arms: the standard chemotherapy regime and radiation dose, the standard chemotherapy with a lower radiation dose, a more intensive chemotherapy regime with the standard radiation dose and the more intensive chemotherapy with a lower radiation dose.

Results of the study confirm that the standard chemotherapy, ABVD, used with the standard dose of radiation therapy, is the best treatment for patients with early, intermediate-stage Hodgkin's lymphoma. Findings also show that a more intensive chemotherapy, BEACOPP, is not more effective than the standard chemotherapy in treating this group of patients.


Contact: Beth Bukata
American Society for Radiation Oncology

Related medicine news :

1. Healthier cafeteria food, more intense gym classes lower students diabetes risk
2. Non-intense physical activity to reduce depression and boost recovery of stroke patients
3. "How Facebook Makes Lonely People Even Lonelier" Revealed by Distinguished University of Chicago Professor in Interview with Brian Vaszily on
4. Intense Cholesterol, Blood Pressure Therapies Dont Help Type 2 Diabetics
5. Chemotherapy plus radiation prevents bladder cancer recurrences
6. Girls with ovarian germ-cell tumors can safely skip chemotherapy unless disease recurs
7. Women fight the effects of chemotherapy long after treatment ends
8. New lung cancer research finds half of advanced lung cancer patients receive chemotherapy
9. IU researchers: Chemotherapy alters brain tissue in breast cancer patients
10. Lung cancer survival rates improved through use of individualized chemotherapy
11. Ancient Chinese medicine may help chemotherapy patients
Post Your Comments:
(Date:11/27/2015)... ... ... According to an article published November 15th by ABC News, ... in light of the recent terrorist attacks in Paris, other cities are taking extra ... from reaching U.S. soil. Especially around special events that may be high-profile in nature, ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... Lizzie’s ... , The company is offering customers 10% off of their purchase of lice treatment ... treatment at full price. According to a company spokesperson. “Finding lice is a sure ...
(Date:11/27/2015)... ... 2015 , ... Intellitec Solutions announced today that they have ... as Microsoft’s official group for end users of Dynamics SL ERP software, the ... experts and representatives. Intellitec Solutions’ membership status demonstrates their ongoing commitment to the ...
(Date:11/27/2015)... ... 2015 , ... The men and women on this list ... the country. They have overseen financial turnarounds, shown commitment to their community through ... as a whole through their advocacy and professional efforts. , Becker's Hospital Review ...
(Date:11/26/2015)... Las Vegas, NV (PRWEB) , ... November 26, 2015 , ... ... holiday shopping strategy. Many customers choose to buy during the Black Friday and ... holiday gifts. Shoppers don’t need to search the Internet high and low to find ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Nov. 26, 2015 ... of the "2016 Global Tumor Marker ... Volume and Sales Segment Forecasts, Innovative Technologies, ... report to their offering. --> ... the "2016 Global Tumor Marker Testing ...
(Date:11/26/2015)... UTRECHT , Nederland, November 26, 2015 ... --> Een nieuwe aanpak combineert ... van gevorderde kanker. ... -->      (Photo: ... van het Leids Universitair Medisch Centrum (LUMC) ...
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
Breaking Medicine Technology: