Navigation Links
Newborns of Smokers Have Abnormal Blood Pressure
Date:1/25/2010

Researchers say aberrations persisted, could raise risk for heart disease later

MONDAY, Jan. 25 (HealthDay News) -- Babies of women who smoked during pregnancy have blood pressure problems at birth that persisted through the first year of life, a new study finds.

"What is of concern is that the problems are present at birth and get worse over time," said Gary Cohen, a senior research scientist in the department of women and child health at the Karolinska Institute in Stockholm, and lead author of a report in the Jan. 25 online edition of Hypertension. "They're not going away, they're getting worse."

The study led by Cohen compared 19 infants of nonsmoking couples with 17 infants born to women who smoked an average of 15 cigarettes a day during pregnancy. At one week of age, the infants of nonsmoking mothers experienced a 2 percent increase in blood pressure when tilted upright, with a 10 percent increase at one year. The pattern for the children of smoking mothers was reversed: a 10 percent blood pressure increase at one week, a 4 percent increase at one year.

And the heart rate response to tilting of the children of mothers who smoked was abnormal and exaggerated, the report said.

It's not possible to say whether the abnormalities seen in the babies will lead to trouble later in life, Cohen said. But, he noted, "the extent of the condition at one year suggests that it is not going to disappear quickly."

The reason why exposure to tobacco in the womb affects blood pressure is not clear, Cohen said. A leading possibility is that "smoking might damage the structure and function of blood vessels," he said, mainly by damaging the endothelium, the delicate layer of cells that line the interior of blood vessels.

Whether that damage will persist is not known. "We're only up to 12 months at the moment," he said. "We plan to follow them."

The damage seen in the Karolinska study is similar to that observed in babies born to mothers whose pregnancies were marked by such abuses as drug use, said Barry M. Lester, a professor of psychiatry and pediatrics at Brown Medical School, and director of the Brown Center for the Study of Children at Risk.

"Early kinds of natal insults can cause reprogramming of brain circuitry," Lester explained. He has led studies of the long-term effects of cocaine and amphetamine use during pregnancy. Many women who take such drugs also smoke, Lester added.

"When we isolated tobacco effects, we showed that there are inborn neural effects of tobacco exposure similar to what we see in cocaine and methamphetamine abuse," he said.

Some research has connected such problems to overproduction of cortisol, a "stress hormone" that plays an important role in regulation of blood pressure and the immune system, Lester said. "Cortisol overexposure is one hypothesis," he said. "There is a lot of evidence showing that too much cortisol is damaging."

It is a reasonable hypothesis, Cohen said. Babies born preterm have problems with blood pressure that have been linked to overproduction of cortisol by the adrenal glands, he noted, "and there are some parallels between tobacco smoke exposure and preterm babies of the same age."

Whatever the mechanism of damage, treatment to eliminate the problems after birth does not seem possible, Cohen added.

"What we know from studies in older kids is that even if you remove them from an environment of exposure to tobacco smoke, it is unlikely you will get full restoration of normal function," he said. "The best intervention to solve these problems is prevention. Women who are pregnant need to avoid exposure to tobacco smoke in the air. Passive smoke exposure can be as bad as being an active smoker."

More information

Problems related to smoking during pregnancy are described by the U.S. Centers for Disease Control and Prevention.



SOURCES: Gary Cohen, Ph.D., senior research associate, department of women and child health, Karolinska Institute, Stockholm, Sweden; Barry M. Lester, Ph.D., professor, psychiatry and pediatrics, Brown Medical School, and director, Brown Center for the Study of Children at Risk, Providence, R.I.; Jan. 25, 2010, Hypertension, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Immune Deficiency Foundation Praises ACHDNC Recommendation for SCID Screening in Newborns
2. Red Reflex Vision Exam Should Be Given to All Newborns, Report Recommends
3. Cooling May Reduce Brain Lesions in Newborns
4. Maternal HIV-1 treatment protects against transmission to newborns
5. Cooling Helps Oxygen-Deprived Newborns
6. Improved Screening for Jaundice Can Protect Newborns
7. Antidepressants Linked to Heart Defects in Newborns
8. Injections May Benefit Oxygen-Deprived Newborns
9. New groundbreaking treatment for oxygen-deprived newborns
10. Screen All Newborns for Hip Dysplasia, Study Urges
11. All Fifty States to Screen Newborns for Cystic Fibrosis by 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
Breaking Medicine Technology: