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Newborn's Placenta May Predict Autism Risk, Study Suggests
Date:4/25/2013

four or more of the inclusions predicted an infant with at least a 74 percent probability of being at risk for autism, the researchers said.

"There were no [placentas from pregnancies not at risk] that had more than two of the folds," Kliman said.

The study only predicted risk of autism, however, not actual autism. The researchers will continue to follow the children.

The testing can't be done before delivery, Kliman said. "You need enough placenta [to examine]."

But the test could help spot at-risk children much earlier than is now possible, Kliman suggested. "There is no way [currently] to know at birth that your child might have autism," he said. "If you know you have a child who is at risk for autism at birth, you are ahead of the game." Interventions can begin early, when the brain is more open to change.

How the folds in the placenta relate to autism risk isn't clear, Kliman said. He and others speculated that the abnormalities in the placentas and the brains of the children affected with autism are marked by increased cellular growth, which then leads to the unusual folding. "The heads of children with autism are bigger," he said. Their brains grow rapidly early in life.

"I'd like to see it as a routine test," Kliman said. The test is labor intensive and requires pathology, however, and Kliman estimated it could cost $2,000 or more.

This isn't the first study to link placental abnormalities with autism risk, said Geraldine Dawson, chief science officer for Autism Speaks, an advocacy and research group. "However, it is one of the largest studies to confirm this finding," she said.

But more research is needed to confirm the findings, she said.

It is too soon to suggest this as a routine test, said Dr. Daniel Coury, medical director of the group's Autism Treatment Network and chief of developmental and behavioral pediatrics at Nationwide Children's Hospital in Columbus, Ohio. He praised the study, but also
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