Navigation Links
Newborn brain cells modulate learning and memory
Date:1/30/2008

La Jolla, CA Boosted by physical and mental exercise, neural stem cells continue to sprout new neurons throughout life, but the exact function of these newcomers has been the topic of much debate. Removing a genetic master switch that maintains neural stem cells in their proliferative state finally gave researchers at the Salk Institute for Biological Studies some definitive answers.

Without adult neurogenesis literally the birth of neurons genetically engineered mice turned into slow learners that had trouble navigating a water maze and remembering the location of a submerged platform, the Salk investigators report in the Jan. 30 Advance Online Edition of Nature. The findings suggest that, one day, researchers might be able to stimulate neurogenesis with orally active drugs to influence memory function, the researchers say.

Our study directly establishes that neurogenesis plays an important role in a defined process, the acquisition and storage of spatial memory, says Howard Hughes Medical Investigator Ronald M. Evans, Ph.D., a professor in the Salk Institutes Gene Expression Laboratory, who, together with his Salk colleague Fred H. Gage, Ph.D., a professor in the Laboratory of Genetics, directed the study.

This finding puts us in a new and important position to exploit the potential of stem cell-based therapies to improve brain function in neurodegenerative diseases such as Alzheimers that are accompanied by a loss of memory, Evans says.

In an earlier collaboration, Evans and Gage had discovered that TLX, a so-called orphan receptor is crucial for maintaining adult neural stem cell in an undifferentiated, proliferative state. Orphan receptors are structurally related to the well-known hormone receptors that mediate steroid and thyroid signaling. In contrast, a TLX regulatory molecule has not yet been identified.

Now, the Salk team wanted to learn more about TLXs biology and function. However, the global deletion
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New research explores newborn in-hospital weight loss
2. Group B Strep: A Threat to Newborns That Doesnt Have to Be
3. Genes Give Clues to Newborn Lung Disease
4. Survival of newborns with abdominal holes differs according to hospital, Hopkins research shows
5. Elective Caesareans Raise Risk of Breathing Problems in Newborns
6. Wisconsin First State in Nation to Screen Newborns for Bubble Boy Disease
7. Better access to cool caps improves outcomes, lowers cost of treating asphyxia in newborns
8. Simple test accurately predicts risk of serious jaundice in newborns
9. Montana Passes Newborn Screening Law for Cystic Fibrosis
10. Draining away brains toxic protein to stop Alzheimers
11. Vision restoration therapy shown to improve brain activity in brain injured patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... new analysis has found that rates of testicular cancer ... Hispanic American men, but not among their non-Hispanic counterparts. ... journal of the American Cancer Society, the findings indicate ... of testicular cancer in Hispanic adolescents and young adults, ... cause of this trend. , Testicular cancer is one ...
(Date:7/14/2014)... EurekaMag.com has newly published results of 64,900 ... disease that ranges in severity from a mild ... illness that attacks the liver. An estimated 3.2 million ... virus infection of which approximately 80% of people develop ... all studies on Hepatitis C , the Life, Earth ...
(Date:7/14/2014)... Wa (PRWEB) July 14, 2014 ... Violet Protocol book review recently updated by ... consists of a wide range of simple ... of endometriosis including:, ... meat and dairy products ,     Increasing ...
(Date:7/14/2014)... 2014 Carepoint has been designed ... by combining an intuitive interface for recording, sending, ... service tracking and reporting features. , Hall mc ... teamed up with Rebecca de Witte to create ... organizations. , Carepoint provides seamless, real-time ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 Vaginal ... continues against seven different pelvic mesh manufacturers in the ... Wright & Schulte LLC. The federal complaints are pending ... No. 2327), American Medical Systems (MDL No. 2325), and ... 16th, there are 58,262 Vaginal Mesh lawsuit claims pending, ...
Breaking Medicine News(10 mins):Health News:Testicular cancer rates are on the rise in young Hispanic Americans 2Health News:EurekaMag.com Publishes 64,900 New Studies on Hepatitis C 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 3Health News:Home Health Care Professional and Marketing Firm Team Up to Create New Homecare Communication App 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 4Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 5
... Committee handed a major victory to the health care industry ... a "public option" to compete against private health insurance providers ... system. The industry has fought the public option with lobbying ... fearing that the proposed policy would cut into their record ...
... ROCKVILLE, Md., Sept. 30 The U.S. Food and ... Consumer Update videos. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ... , http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm182842.htm , ... Approximately 30,000 Americans go to the emergency room each ...
... Corporation ("Select") (NYSE: SEM ), the parent of Select ... public offering of common stock at a price of $10.00 ... Select,s stock began trading on the New York Stock ... Total net proceeds to Select from the offering, after deducting ...
... Simmons firm, a leading national law firm in the fight ... Miles for Meso 5K run/walk on Sunday, October 11, in ... www.milesformeso.org . , The Simmons firm ... in Alton, Ill. Nearly 500 runners and walkers registered, and ...
... ... ), a comprehensive New Jersey anti-poverty charity, is serving more than 500 hot meals ... Services Corp. ( http://www.servicer.com ) and Rapid Pump & Meter Service Co., Inc., ( ... , ...
... problems later , WEDNESDAY, Sept. 30 (HealthDay News) -- New ... reduces the risk for neurological problems later. , Unfortunately, the ... disability. , Still, the findings, appearing in the Oct. 1 ... help fill a crucial gap in the effort to treat ...
Cached Medicine News:Health News:Insurance Industry Successful in Initial Fight Against Public Option; Public Feels Left Out 2Health News:Insurance Industry Successful in Initial Fight Against Public Option; Public Feels Left Out 3Health News:FDA Consumer Health Information Updates: New Web Videos Educate Consumers About Food and Medical Product Safety 2Health News:Select Medical Holdings Corporation Successfully Completes Initial Public Offering of Common Stock 2Health News:Simmons Law Firm Presents Second 'Miles for Meso' Walk/Run Fundraiser for Mesothelioma Research 2Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 2Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 3Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 4Health News:Cooling Helps Oxygen-Deprived Newborns 2Health News:Cooling Helps Oxygen-Deprived Newborns 3
(Date:7/11/2014)... 11, 2014 The consumer marketing playbook ... industry sectors to better identify winning tools and ... engage with and understand consumers, as new technologies ... critical purchasing decisions. According to ... one area where organizations can observe a deep ...
(Date:7/11/2014)... -- Research and Markets has announced the ... Film Industry Report 2014" report to their offering. ... Global And Chinese Medical X-Ray Film Industry Report 2014 ... state of the Global medical X-ray film industry with ... provides a basic overview of the industry including definitions, ...
(Date:7/11/2014)... , July 11, 2014 Research and ... Hypodermic Needles Market 2014-2018" report to their offering. ... A hypodermic needle is a hollow needle commonly used ... or or to extract fluids from it. A hypodermic ... to inject substances that cannot be ingested. Hypodermic needles ...
Breaking Medicine Technology:New Technologies Transforming Consumer Marketing Research Playbook 2Global and Chinese Medical X-ray Film Industry Report 2014 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3
... River Systems, Inc. announces today that it has ... Massachusetts Institute of Technology (M.I.T.) to utilize advanced ... and Fusion Center in collaboration with Still River. ... with its own leading-edge developments in its groundbreaking ...
... 22, 2011 CardioFocus, Inc., developer of the HeartLight™ ... fibrillation (AF), announced today that its technology will be ... European Heart Rhythm Association (EHRA) EUROPACE 2011 congress, June ... is a unique catheter ablation technology that incorporates an ...
Cached Medicine Technology:Still River Systems Sign Patent License Agreement With the Massachusetts Institute of Technology 2CardioFocus HeartLight™ Endoscopic Ablation System to be Featured at EHRA EUROPACE 2011 2CardioFocus HeartLight™ Endoscopic Ablation System to be Featured at EHRA EUROPACE 2011 3
Solid steel construction for lifelong quality. Strong, smooth and quiet electro-mechanical up/down movement. Dual castor, locking wheels for use on carpet or tile flooring. Easy cleaning, deluxe lami...
Trial lens set +/- Cyl....
... control panel with 3 charging wells. Available ... Colonial Blue and Cinnamon. Spring balanced refractor ... and steel construction for lifelong quality. Sealed ... up/down chair movement. Chair back reclines manually ...
Our Ophthalmic Diagnostic Sets offer everything an eye care specialist needs. Complete your set with your choice of ophthalmoscope, retinoscope, handle, and case....
Medicine Products: