Navigation Links
Newborn brain cells modulate learning and memory
Date:1/30/2008

La Jolla, CA Boosted by physical and mental exercise, neural stem cells continue to sprout new neurons throughout life, but the exact function of these newcomers has been the topic of much debate. Removing a genetic master switch that maintains neural stem cells in their proliferative state finally gave researchers at the Salk Institute for Biological Studies some definitive answers.

Without adult neurogenesis literally the birth of neurons genetically engineered mice turned into slow learners that had trouble navigating a water maze and remembering the location of a submerged platform, the Salk investigators report in the Jan. 30 Advance Online Edition of Nature. The findings suggest that, one day, researchers might be able to stimulate neurogenesis with orally active drugs to influence memory function, the researchers say.

Our study directly establishes that neurogenesis plays an important role in a defined process, the acquisition and storage of spatial memory, says Howard Hughes Medical Investigator Ronald M. Evans, Ph.D., a professor in the Salk Institutes Gene Expression Laboratory, who, together with his Salk colleague Fred H. Gage, Ph.D., a professor in the Laboratory of Genetics, directed the study.

This finding puts us in a new and important position to exploit the potential of stem cell-based therapies to improve brain function in neurodegenerative diseases such as Alzheimers that are accompanied by a loss of memory, Evans says.

In an earlier collaboration, Evans and Gage had discovered that TLX, a so-called orphan receptor is crucial for maintaining adult neural stem cell in an undifferentiated, proliferative state. Orphan receptors are structurally related to the well-known hormone receptors that mediate steroid and thyroid signaling. In contrast, a TLX regulatory molecule has not yet been identified.

Now, the Salk team wanted to learn more about TLXs biology and function. However, the global deletion
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New research explores newborn in-hospital weight loss
2. Group B Strep: A Threat to Newborns That Doesnt Have to Be
3. Genes Give Clues to Newborn Lung Disease
4. Survival of newborns with abdominal holes differs according to hospital, Hopkins research shows
5. Elective Caesareans Raise Risk of Breathing Problems in Newborns
6. Wisconsin First State in Nation to Screen Newborns for Bubble Boy Disease
7. Better access to cool caps improves outcomes, lowers cost of treating asphyxia in newborns
8. Simple test accurately predicts risk of serious jaundice in newborns
9. Montana Passes Newborn Screening Law for Cystic Fibrosis
10. Draining away brains toxic protein to stop Alzheimers
11. Vision restoration therapy shown to improve brain activity in brain injured patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... (PRWEB) November 27, 2014 Jeffrey ... years in the Charlotte area providing audits, reviews, ... services to businesses of varying size across numerous ... owners to meet all of their accounting and ... through the QuickBooks ProAdvisor Program. When asking Mr. ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 VogueQueen.com is ... items for ladies across the world. As the premier ... accessories, VogueQueen.com is proud to release a huge selection ... high quality outfits, it is also providing many beautiful ... VogueQueen prom gowns at discounted prices. , “VogueQueen.com ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 Dr. Ronald Receveur, ... has a few oral health tips before patients dig ... offers Louisville and New Albany affordable cosmetic dentistry, ... high in starch and sugar. While the staff wishes everyone ... helpful tips for how patients can enjoy a feast that ...
(Date:11/27/2014)... children to help with chores while they are home from ... boosts self-esteem, and above all, helps parents maintain a somewhat ... how do you encourage your children to want to help? ... Child Development Journal, there is. The study found that adults’ ... to lend a hand. , The study found that ...
(Date:11/27/2014)... Ethane Web Technologies, which is an ... reputation management service. , The company has designed ... world of internet marketing and algorithms of major search ... Web Technologies does not work with the same strategy ... to reach a conclusion what will work for the ...
Breaking Medicine News(10 mins):Health News:Jeffrey Carlini becomes Intuit Proadvisor and receives QuickBooks certification 2Health News:A New Collection of Sexy Prom Dresses Has Been Released by the Reliable Online Supplier VogueQueen.com 2Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 2Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 3Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 4Health News:Ethane Web Technologies Announces Online Reputation Management Service 2
... reports little coronary benefit, regardless of when treatment begins , ... not lower the odds of heart trouble in women who ... of menopause, a new study reports. , In fact, the ... attacks for the first two years of use. , ...
... ... Awards (FOYA) were announced by the program’s sponsors, ISPE, INTERPHEX, and Pharmaceutical Processing ... their operations to yield top quality products. Two of this year’s winning companies ... ...
... ... Green” to the Next Level., , ... Tampa, FL (PRWEB) February 18, 2010 -- Super Green Technologies, ... tankless water heaters on the market today. Super Green Technologies water heaters utilize ...
... Van Andel Research Institute (VARI) researchers have found a ... currently the first line of defense against clear cell renal ... Most patients who show a positive response to sunitinib develop ... Kidney cancer is among the 10 most common cancers ...
... due to complications arising from pregnancy and childbirth. Half of ... the King Juan Carlos University (URJC) in Madrid says these ... but rather from a lack of basic healthcare measures. ... situation and of the inequalities between men and women", Jos ...
... ... Global Business to Business (B2B) Video Network , ... Toronto, Canada (PRWEB) February 18, 2010 -- BCS Global ... telepresence solutions, today announced that it has launched the PSVN (Public Switched Video Network) ...
Cached Medicine News:Health News:Early On, Hormone Therapy May Raise Women's Heart Risks 2Health News:Early On, Hormone Therapy May Raise Women's Heart Risks 3Health News:Awards Strengthen Stonhard's Reputation for High-Performing Floors in the World's Most Prominent Pharmaceutical Facilities 2Health News:First Breakthrough in Water Heating Technology! 2Health News:First Breakthrough in Water Heating Technology! 3Health News:VARI findings may help patients with deadly kidney cancer 2Health News:Most maternal deaths in sub-Saharan Africa could be avoided 2Health News:BCS Global Launches PSVN (Public Switched Video Network), an Initiative to Provide a Framework for Inter-Connecting Business to Business Video Networks 2Health News:BCS Global Launches PSVN (Public Switched Video Network), an Initiative to Provide a Framework for Inter-Connecting Business to Business Video Networks 3Health News:BCS Global Launches PSVN (Public Switched Video Network), an Initiative to Provide a Framework for Inter-Connecting Business to Business Video Networks 4Health News:BCS Global Launches PSVN (Public Switched Video Network), an Initiative to Provide a Framework for Inter-Connecting Business to Business Video Networks 5
(Date:11/26/2014)... Texas , Nov. 26, 2014 ... today announced the completion of previously announced concurrent ... million.  After fees and estimated offering expenses, Lexicon ... the transactions.  The transactions consisted of: ... common stock, pursuant to a registration statement that ...
(Date:11/26/2014)...  Over 100 million adults suffer from chronic pain ... daily. Chronic and acute pain dramatically impacts quality of ... fulfill the need for non-surgical, interventional solutions and medication ... On October 28th, a new pain management center opened ... community.  This new facility boasts cutting edge technologies ...
(Date:11/26/2014)... 2014  BioScrip ® , Inc. (NASDAQ: BIOS ) ... Executive Officer, will present at the Bank of America Merrill Lynch ... , Date: , , , Wednesday, December 3, 2014 , ... , , , Location: , , , Boca Raton Resort ... Inc. BioScrip, Inc. is a leading national ...
Breaking Medicine Technology:Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3New Pain Management Center Opens in Cumberland, Md. 2
... flexible, total solution. , ,Kojair Tech Oy has ... A major part of our production is marketed ... the different areas of clean-air needs are a ... is a comprehensive supplier. We are able to ...
... 95% media meets today's ASHRAE ... contaminant reduction. The unique, patented ... DEFIANT filters creates a media ... respect to initial efficiency, average ...
The Universal Knee Positioner(s)™ reduces surgeon fatigue while assisting in the stabilization of a patient's leg during surgury....
BRAT 2 Autologous Blood Recovery System gives performance, speed, versatility, and quality processing. , ,The BRAT 2 is now available with on-board Vacuum, programmability, plasma sequestration, Data...
Medicine Products: