Navigation Links
New weapon against highly resistant microbes within grasp
Date:5/27/2010

An active compound from fungi and lower animals may well be suitable as an effective weapon against dangerous bacteria. We're talking about plectasin, a small protein molecule that can even destroy highly resistant bacteria . Researchers at the Universities of Bonn, Utrecht, Aalborg and of the Danish company Novozymes AS have shed light on how the substance does this. The authors see plectasin as a promising lead compound for new antibiotics.

These results will be published in Science journal on 28th May.

More and more bacteria are becoming resistant to normal antibiotics. This is especially true for the methicillin-resistant Staphylococcus aureus (MRSA). Most of the pharmaceutical weapons are now useless against these MRSA strains . According to estimates, as many as every second patient in the USA treated by intensive-care medicine comes down with an MRSA infection.

Plectasin could shift the balance of power back in the doctors' favour. But how exactly does the little protein molecule do that? The Bonn researchers in Dr. Tanja Schneider and Professor Hans-Georg Sahl's team have answered these questions together with Danish and Dutch colleagues. Thus plectasin disrupts the forming of the cell wall in bacteria so that the pathogens can no longer divide.

Theft at the bacteria's construction site

In this process, plectasin behaves like a thief which steals the stones off a mason. 'It binds to a cell-wall building block called lipid II and thus prevents it from being incorporated ,' Professor Sahl explains. 'However, bacteria cannot live without a cell wall.' It comes as no surprise that the most famous antibiotic penicillin also inhibits cell-wall synthesis.

Yet plectasin is more similar in its mode of action to another widely used drug, vancomycin. Vancomycin had been the drug of choice in combating MRSA strains since the 1980s. Meanwhile, though, there are more and more bacteria that are also resistant to vancomycin. 'However, these strains are still susceptible to plectasin,' Dr. Tanja Schneider emphasises. Nevertheless, there is no permanent solution to the resistance problem even with a new antibiotic . 'It is always just a question of time until the pathogens mutate and become insensitive ,' she says. 'It's a never ending arms race.'

Plectasin belongs to the class of defensins. These defence molecules are widespread among fungi, animals and also plants. Humans, for example, produce defensins on their skin and in this way nip infections in the bud. 'Defensins not only kill pathogens but also alert the immune system', Dr. Hans-Henrik Kristensen from the Danish company Novozymes AS explains. 'So the pharmaceutical industry is setting its hopes on them.'


'/>"/>

Contact: Dr. Hans-Georg Sahl
hgsahl@uni-bonn.de
49-228-737-941
University of Bonn
Source:Eurekalert

Related medicine news :

1. The almond trees secret weapon
2. A Healthy Diet Remains Your Best Weapon Against the #1 Killer: Heart Disease
3. Stents May Be Effective Weapon Against Stroke
4. Keeping the Boston Bruins Healthy. Their New - Very Cold - Secret Weapon Against Injuries
5. Global Aids Alliance Celebrates the Introduction of the International Violence Against Women Act, Urges Swift Passage
6. More than 30 Percent of Seniors Are Not Immunized Against Pneumonia in 36 States; New Report Finds Low Adult Vaccination Rates in U.S.
7. More than 30 percent of seniors are not immunized against pneumonia in 36 states
8. Acupuncture found effective against depression during pregnancy
9. Tobacco Heir to Speak Out Against Tobacco at Saint Francis Hospital
10. Black Community Unites Against HIV/AIDS Epidemic
11. Luis Tiant and Sunridge International Partner to Provide Medical Relief in Cuba: Former Star Pitcher for the Red Sox and Yankees Leads the Fight Against Glaucoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a ... of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners ... October 11, 2017. , The annual award competition recognizes editorial and design excellence across ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based workplace ... Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored at ... from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra ... care advancements to physician colleagues, skilled nursing facility medical directors and other clinicians ... Waters of Wound Care." , "At many of these conferences we get to ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: