Navigation Links
New ways to protect female fertility
Date:9/21/2012

New research offers hope to women whose fertility has been compromised by the side-effects of cancer therapy or by premature menopause.

In a study published today in Molecular Cell, researchers from the Walter and Eliza Hall Institute (WEHI), Monash University and Prince Henry's Institute of Medical Research found that two proteins, PUMA and NOXA, cause the death of egg cells in the ovaries. Blocking the activity of the proteins may lead to new strategies to protect women's fertility.

The team, including Associate Professor Jeffrey Kerr from Monash, Associate Professor Clare Scott, Dr Ewa Michalak and Professor Andreas Strasser from WEHI and Dr Karla Hutt and Professor Jock Findlay from PHI, focused their studies on egg cells called primordial follicle oocytes, which provide each woman's lifetime supply of eggs. Low numbers of these egg cells can also cause early menopause.

Associate Professor Clare Scott, an oncologist at The Royal Melbourne and Royal Women's hospitals, said the research showed that when the DNA of egg cells is damaged following exposure to radiation or chemotherapy, PUMA and NOXA trigger the death of the damaged eggs, leading to infertility in many female cancer patients.

"PUMA and NOXA can trigger cell death, and have been found to be necessary for the death of many different cell types in response to DNA damage," Associate Professor Scott said.

"This removal of damaged cells is a natural process that is essential to maintaining health but, for women undergoing cancer treatment, can be devastating when it leads to infertility."

Associate Professor Kerr said that when these egg-producing cells were missing the PUMA protein they did not die after being exposed to radiation therapy.

"This might ordinarily be cause for concern because you want damaged egg cells to die so as not to produce abnormal offspring," he said.

"To our great surprise we found that not only
'/>"/>

Contact: Emily Walker
emily.walker@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sexting May Go Hand-in-Hand With Unprotected Sex Among Teens
2. Whooping Cough Vaccine Protection Fades Over Time: Study
3. Weapon-wielding marine microbes may protect populations from foes
4. Stem-cell-protecting drug could prevent the harmful side effects of radiation therapy
5. Canada needs national approach to protect against drug shortages
6. Some Families May Have Natural Protection Against Dementia
7. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
8. Mediterranean diet enriched with olive oil may protect bone
9. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
10. Rejected drug may protect against toxic substance common to Alzheimers and Parkinsons diseases
11. New Vaccine May Offer Protection From Deadly Nipah Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... ... Trenton Health Team has been certified by the New Jersey Department of ... State, serving the greater Trenton community. The ACO pilot is for a three-year ... collaborative structure of THT, bringing together the vast majority of Trenton’s primary and specialty ...
(Date:6/30/2015)... ... June 30, 2015 , ... Today, Grand Terrace Health Care ... Care Center.” Each year, Medicare ranks care centers around the country in an ... their needs. Grand Terrace prides itself on quality in each of Medicare’s evaluation ...
(Date:6/30/2015)... Sacramento, CA (PRWEB) , ... June 30, 2015 ... ... on YouTube titled, “University Post-Acute Rehab”. The video focuses on the rehab center’s ... Five-Star rating, indicating it provides the best quality of services available. Each patient ...
(Date:6/30/2015)... , ... June 30, 2015 , ... On June 26, ... Acne ,” listed five triggers that most people would not expect to cause ... and toothpaste. The primary causes of acne are clogged pores and bacteria ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... eyeglasses online , finally its here, http://www.express-glasses.com is proud to ... for many location, ask about shipping with DHL Express when calling or visiting ...
Breaking Medicine News(10 mins):Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 2Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 3Health News:Grand Terrace Health Care Center Announces Five-Star Rating in YouTube Video 2Health News:Patients of University Post-Acute Rehab Support Five-Star Rating in New Video 2Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2Health News:Eyeglasses Online - Express Glasses Announcing New International Shipping Using DHL 2
... infants and children in India over the past 20 years ... a new study led by researchers at the Harvard School ... births occurring between 1985 and 2005, the researchers found that ... female children, but not male children, in both the first ...
... of Medicine has developed the first web-based screening tool ... been used by soldiers returning from the wars in ... Road to Recovery Conference and Tribute in Orlando to ... brain injury is underdiagnosed, and left untreated can have ...
... a thermostatic mixer valve to control the maximum temperature ... of hot bath water and should reduce the risk ... Nottingham. The study, carried out in partnership with ... mixing valve (TMV) fitted to the hot and cold ...
... (HealthDay News) -- People enrolled in Medicare Advantage private ... plans, but a national consumer group urges a careful ... what the Medicare agency calls the Medicare Advantage Disenrollment ... only to traditional Medicare coverage administered by the federal ...
... the varicella, or chickenpox, vaccine provide excellent protection in children ... To be published in the February 1 issue of The ... two-dose vaccine regimen recommended in the United States since 2006. ... The Centers for Disease Control and Prevention (CDC) began ...
... Mozes HealthDay Reporter , TUESDAY, Jan. 4 ... in a newly identified stem cell defect, a finding ... the road, a new study reveals. Researchers say ... by which hair follicle stem cells turn into hair-producing ...
Cached Medicine News:Health News:Violence against mothers linked to 1.8 million female infant and child deaths in India 2Health News:Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury 2Health News:Thermostatic mixer valves could significantly reduce the risk of scalding in children, study finds 2Health News:Thermostatic mixer valves could significantly reduce the risk of scalding in children, study finds 3Health News:People Dropping 'Medicare Advantage' Urged to Analyze Options 2Health News:Study confirms 2 vaccine doses protect children from chickenpox 2Health News:Stem Cell Defect Might Help Spur Common Baldness 2Health News:Stem Cell Defect Might Help Spur Common Baldness 3
(Date:6/30/2015)... , June 30, 2015  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that the ... 14, 2015, from 8:00 a.m.- 1:00 pm EDT in ... The Ardelyx senior management team will present an ... compound, tenapanor, which has completed Phase 2b clinical trials ...
(Date:6/30/2015)... JERUSALEM , June 30, 2015 ... http://www.oramed.com ), a clinical-stage pharmaceutical Company focused on the ... the first patient has been screened in the Company,s ...  This U.S. based study will be performed under the ... the U.S. Food and Drug Administration (FDA). ...
(Date:6/30/2015)... 2015 /PRNewswire/ – Small Cap IR issues report. Recently, ... custom Arrayit blood card technology to Vivos, Global Genome ... Vivos offers an impervious, impenetrable and permanent DNA storage ... child on Earth, a safe and secure nuclear blast-proof, ... allow the rapid collection, separation, drying and storage of ...
Breaking Medicine Technology:Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 2Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 3Small Cap IR - Empowering the Age of Genetic Enlightenment 2
The adult blanket provides full coverage for patients of all sizes. The generous size and versatility of these blankets include extra material for the shoulders and feet. The foot drape also reduces ...
This revolutionary system combines the CSZ Head Wrap and Patient Vest for a non-invasive whole body hypothermia system. This method of cooling the patient allows for early treatment that is fast, cos...
The fabric is antistatic and non-linting and is both oil and water repellent.These superior blankets are an environmental friendly alternative to disposable blankets....
The Bair Hugger outpatient blanket makes it easy to give your patients the benefit of prewarming and enhance patient comfort during outpatient procedures....
Medicine Products: