Navigation Links
New ways to protect female fertility
Date:9/21/2012

New research offers hope to women whose fertility has been compromised by the side-effects of cancer therapy or by premature menopause.

In a study published today in Molecular Cell, researchers from the Walter and Eliza Hall Institute (WEHI), Monash University and Prince Henry's Institute of Medical Research found that two proteins, PUMA and NOXA, cause the death of egg cells in the ovaries. Blocking the activity of the proteins may lead to new strategies to protect women's fertility.

The team, including Associate Professor Jeffrey Kerr from Monash, Associate Professor Clare Scott, Dr Ewa Michalak and Professor Andreas Strasser from WEHI and Dr Karla Hutt and Professor Jock Findlay from PHI, focused their studies on egg cells called primordial follicle oocytes, which provide each woman's lifetime supply of eggs. Low numbers of these egg cells can also cause early menopause.

Associate Professor Clare Scott, an oncologist at The Royal Melbourne and Royal Women's hospitals, said the research showed that when the DNA of egg cells is damaged following exposure to radiation or chemotherapy, PUMA and NOXA trigger the death of the damaged eggs, leading to infertility in many female cancer patients.

"PUMA and NOXA can trigger cell death, and have been found to be necessary for the death of many different cell types in response to DNA damage," Associate Professor Scott said.

"This removal of damaged cells is a natural process that is essential to maintaining health but, for women undergoing cancer treatment, can be devastating when it leads to infertility."

Associate Professor Kerr said that when these egg-producing cells were missing the PUMA protein they did not die after being exposed to radiation therapy.

"This might ordinarily be cause for concern because you want damaged egg cells to die so as not to produce abnormal offspring," he said.

"To our great surprise we found that not only did the cells survive being irradiated, they were able to repair the DNA damage they had sustained and could be ovulated and fertilised, producing healthy offspring. When the cells were also missing the NOXA protein, there was even better protection against radiation."

Future treatments could block the function of PUMA, preventing egg cell death in patients undergoing chemotherapy or radiation.

Professor Jock Findlay, head of the Female Reproductive Biology Group at PHI, said the study could also have implications for delaying menopause.

"We know that the timing of menopause is influenced by how many egg cells a female has," he said. "Interventions that slow the loss of egg cells from the ovaries could delay premature menopause, prolonging female fertility, such a treatment could have the potential to reduce menopause-associated health conditions, such as osteoporosis and heart disease."


'/>"/>

Contact: Emily Walker
emily.walker@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Related medicine news :

1. Sexting May Go Hand-in-Hand With Unprotected Sex Among Teens
2. Whooping Cough Vaccine Protection Fades Over Time: Study
3. Weapon-wielding marine microbes may protect populations from foes
4. Stem-cell-protecting drug could prevent the harmful side effects of radiation therapy
5. Canada needs national approach to protect against drug shortages
6. Some Families May Have Natural Protection Against Dementia
7. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
8. Mediterranean diet enriched with olive oil may protect bone
9. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
10. Rejected drug may protect against toxic substance common to Alzheimers and Parkinsons diseases
11. New Vaccine May Offer Protection From Deadly Nipah Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: