Navigation Links
New ways to protect female fertility
Date:9/21/2012

New research offers hope to women whose fertility has been compromised by the side-effects of cancer therapy or by premature menopause.

In a study published today in Molecular Cell, researchers from the Walter and Eliza Hall Institute (WEHI), Monash University and Prince Henry's Institute of Medical Research found that two proteins, PUMA and NOXA, cause the death of egg cells in the ovaries. Blocking the activity of the proteins may lead to new strategies to protect women's fertility.

The team, including Associate Professor Jeffrey Kerr from Monash, Associate Professor Clare Scott, Dr Ewa Michalak and Professor Andreas Strasser from WEHI and Dr Karla Hutt and Professor Jock Findlay from PHI, focused their studies on egg cells called primordial follicle oocytes, which provide each woman's lifetime supply of eggs. Low numbers of these egg cells can also cause early menopause.

Associate Professor Clare Scott, an oncologist at The Royal Melbourne and Royal Women's hospitals, said the research showed that when the DNA of egg cells is damaged following exposure to radiation or chemotherapy, PUMA and NOXA trigger the death of the damaged eggs, leading to infertility in many female cancer patients.

"PUMA and NOXA can trigger cell death, and have been found to be necessary for the death of many different cell types in response to DNA damage," Associate Professor Scott said.

"This removal of damaged cells is a natural process that is essential to maintaining health but, for women undergoing cancer treatment, can be devastating when it leads to infertility."

Associate Professor Kerr said that when these egg-producing cells were missing the PUMA protein they did not die after being exposed to radiation therapy.

"This might ordinarily be cause for concern because you want damaged egg cells to die so as not to produce abnormal offspring," he said.

"To our great surprise we found that not only did the cells survive being irradiated, they were able to repair the DNA damage they had sustained and could be ovulated and fertilised, producing healthy offspring. When the cells were also missing the NOXA protein, there was even better protection against radiation."

Future treatments could block the function of PUMA, preventing egg cell death in patients undergoing chemotherapy or radiation.

Professor Jock Findlay, head of the Female Reproductive Biology Group at PHI, said the study could also have implications for delaying menopause.

"We know that the timing of menopause is influenced by how many egg cells a female has," he said. "Interventions that slow the loss of egg cells from the ovaries could delay premature menopause, prolonging female fertility, such a treatment could have the potential to reduce menopause-associated health conditions, such as osteoporosis and heart disease."


'/>"/>

Contact: Emily Walker
emily.walker@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Related medicine news :

1. Sexting May Go Hand-in-Hand With Unprotected Sex Among Teens
2. Whooping Cough Vaccine Protection Fades Over Time: Study
3. Weapon-wielding marine microbes may protect populations from foes
4. Stem-cell-protecting drug could prevent the harmful side effects of radiation therapy
5. Canada needs national approach to protect against drug shortages
6. Some Families May Have Natural Protection Against Dementia
7. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
8. Mediterranean diet enriched with olive oil may protect bone
9. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
10. Rejected drug may protect against toxic substance common to Alzheimers and Parkinsons diseases
11. New Vaccine May Offer Protection From Deadly Nipah Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... ... the certification process to promote standards of excellence for the field of eating ... for March 22 – 25, 2018 in Orlando, Florida at the Omni Resort ...
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “The Journey: ... faced every danger possible to save lost souls in the Philippines. “The Journey: From ... Carole is a dedicated teacher of the Bible. She has taught all ages and ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
(Date:10/2/2017)... -- AllianceRx Walgreens Prime, the combined central specialty pharmacy and ... manager Prime Therapeutics LLC (Prime), today officially began the ... of new signage at its headquarters in ... few other company-owned facilities across the country. This also ... whom will begin to see the AllianceRx Walgreens Prime ...
Breaking Medicine Technology: