CHAMPAIGN, Ill. The news a cancer patient most fears is that the disease has spread and become much more difficult to treat. A new method to isolate and grow the most dangerous cancer cells could enable new research into how cancer spreads and, ultimately, how to fight it.
University of Illinois researchers, in collaboration with scientists at the Huazhong University of Science and Technology in China, published their results in the journal Nature Materials.
"This may open the door for understanding and blocking metastatic colonization, the most devastating step in cancer progression," said Ning Wang, a professor of mechanical science and engineering who co-led the study.
The most dangerous cancer cells are the ones that can break away from the primary tumor and travel through the body to form a new tumor in another tissue, a process called metastasis. Fortunately, only a small percentage of cancer cells have the ability to become new tumors. Unfortunately, the tumor-seeding cells are the ones hardest to kill with chemotherapy and it only takes a lone survivor to mount a resurgence.
Cancer researchers have theorized that these elusive tumor-spreading cells may be responsible for recurrences after surgery or treatment. They are very interested in studying these cells in hopes of better understanding and ultimately combating them. However, identifying and isolating metastatic cells from a general cancer cell population is very difficult.
One hotly debated question is whether metastatic cells share characteristics of stem cells, and if so, to what extent. Some studies have found cancer cells with stem-cell markers, others have displayed stem-cell-like behavior, and yet others have suggested that cells can spontaneously switch from a primary cancer cell to a stem-cell-like cancer cell and back.
Wang's group at the U. of I. had previously found that stem cells grow better in a soft gel than on a rigid
|Contact: Liz Ahlberg|
University of Illinois at Urbana-Champaign