Navigation Links
New way to diagnose Alzheimer's disease promises earlier treatment
Date:9/17/2007

Physicians may be able to detect and treat Alzheimers Disease (AD) in its earliest stages, when patients are experiencing only mild degrees of cognitive impairment, thanks to new diagnostic criteria proposed by an international group of researchers.

Published in Lancet Neurology, the development of new guidelines was co-led by Dr. Howard Feldman, head of the Div. of Neurology in the University of British Columbias Faculty of Medicine. Feldman, who directs the Clinic for Alzheimers Disease and Related Disorders at Vancouver Coastal Health, co-authored the paper with French researcher Dr. Bruno Dubois and investigators from countries that include Japan, the U.S. and England. Feldman is a member of Vancouver Coastal Health Research Institute (VCHRI).

The proposed criteria are based on examining the structure and function of the brain using advanced brain imaging techniques as well as looking at spinal fluid for the imprint of the disease. Early detection will allow researchers to test vaccines that might be used preventively or to treat fully affected individuals, or other drug treatments that are directed at the earliest stages of the disease the best time to reduce symptoms.

Existing criteria, established in 1984, involve a two-step approach of evaluating functional disability and then looking for a cause, meaning diagnosis and treatment is delayed until patients have significant dementia symptoms. Integrating the profound neurobiological advances of the last 20 years allow for diagnoses based on more than declining functional ability, says Feldman, a senior investigator with the Brain Research Centre (BRC) at UBC Hospital. We now have advanced diagnostic tools distinctive and reliable biological indicators that can be detected before the patient crosses the dementia threshold of disability.

The new criteria the researchers are proposing to the scientific community via the article represent a significant shift and will direct scientists and clinicians to a different focus than has been pursued over the last decade, he adds.

New diagnostic measures include a clinical core of early, progressive and significant episodic memory loss plus one or more abnormal biomarkers (biological indicators) characteristic of AD, including atrophy (wasting) of the temporal lobe as shown on Magnetic Resonance Imaging; abnormal amyloid Beta protein concentrations in the cerebrospinal fluid; a specific pattern showing reduced glucose metabolism on Positron Emission Tomography scans of the brain; and a genetic mutation for AD within the immediate family.

AD is a neurodegenerative disease characterized by progressive cognitive deterioration and is the most common form of dementia. The Alzheimer Society of Canada estimates that the disease affects more than 238,000 Canadians and that by 2031 about 750,000 Canadians will suffer from AD and related dementias. Approximately $5.5 billion per year is spent caring for persons with AD and related dementias in Canada. The Alzheimers Association in the U.S. estimates there are approximately 500,000 Americans younger than 65 with Alzheimers or other dementia.

Validation studies are needed to further explore the criteria and improve their sensitivity, specificity and accuracy, say the researchers.


'/>"/>

Contact: Hilary Thomson
Hilary.thomson@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Related medicine news :

1. How to diagnose heart failure?
2. Pain-Free Heart Attacks Often Misdiagnosed
3. New technique to diagnose heart disease
4. Blood test diagnoses heart failure in short time
5. Heart disease diagnosed by dentist?
6. A Simple Exercise Can Uncover Undiagnosed Asthma
7. Breast Cancer Diagnosed Late In Men
8. Imaging Modality That Might Help Diagnose Depression
9. Restless leg syndrome may remain under-diagnosed in many
10. Stroke In The Right-Brain Can Remain Undiagnosed
11. Eye Diseases Diagnosed Through Genetical Testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... ... “The Perfect Gift”: a customizable and interactive Bible study guide for children. “The Perfect Gift” ... She has always accepted Christ as her Savior, yet never studied His word, surrendered ... when she wrote this book to her children, so they would know the importance of ...
(Date:7/24/2017)... , ... July 24, 2017 , ... “A Short Walk ... to the Mailbox” is the creation of published author, Ed Clark. Ed Clark ... Methodist, and Christian Reformed churches as a minister of music and worship leader for ...
(Date:7/24/2017)... ... 24, 2017 , ... The Center for Addiction Recovery Training ... host a second Multiple Pathways of Recovery Conference on October 23-26, 2017. This ... from CCAR’s foundational principle – a belief in multiple pathways of recovery, aims ...
(Date:7/23/2017)... IL (PRWEB) , ... July ... ... of Eating Disorders Professionals ™(iaedp), the leading provider of education and training ... training in preparation for competency for Traditional Certification: the iaedp™ Core Curriculum. ...
(Date:7/23/2017)... ... July 23, 2017 , ... Scientists from the University of ... bursts of high-intensity, weight-bearing activity equivalent to a medium-paced run for pre-menopausal women, or ... surgeon who specializes in total spine care, I understand the importance exercise can play ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... BOTHELL, Wash. , July 5, 2017   ... a leading developer, manufacturer and marketer of proprietary clinical ... cryopreservation freeze media ("BioLife"), today announced that ... ("WAVI") its debt holder and largest shareholder, to modify ... Pursuant to the modification, WAVI agreed to ...
(Date:6/30/2017)... 30, 2017  AVACEN Medical (AVACEN) announced the publication of new ... the use of its AVACEN Treatment Method to significantly ... ... AVACEN Medical ... widespread pain. It affects approximately 200 to 400 million people worldwide according ...
(Date:6/27/2017)... Calif. , Jun 27, 2017   NuEyes ... round of funding to fuel its growth in helping the ... ODG (Osterhout Design Group), the leading developer of augmented, ... NuEyes technology sits. The undisclosed funding amount was ... capital firm, Arab Angel, with offices in Abu ...
Breaking Medicine Technology: