Navigation Links
New view of tumors' evolution
Date:3/13/2014

CAMBRIDGE, MA -- Cancer cells undergo extensive genetic alterations as they grow and spread through the body. Some of these mutations, known as "drivers," help spur cells to grow out of control, while others ("passengers") are merely along for the ride.

MIT cancer biologists at the Koch Institute for Integrative Cancer Research and geneticists from the Broad Institute have now performed the most comprehensive analysis to date of these changes in mice programmed to develop cancer. The team discovered mutations and other genetic disturbances that arise at certain stages of lung cancer development; the researchers were also able to identify tumor cells that broke free to spread to other organs.

The findings, described in the March 13 issue of Cell, suggest possible new targets for drugs for this aggressive form of cancer, known as small cell lung cancer. There are now very few targeted drugs for small cell lung cancer, a highly lethal form of lung cancer that is associated with tobacco use and is usually treated with chemotherapy drugs that have severe side effects.

"Right now, small cell lung cancer is really lagging behind with respect to therapies that target a specific mutation or genetic alteration in the tumors, because we don't know a lot about the drivers in these cancers," says David McFadden, a postdoc at MIT's Koch Institute for Integrative Cancer Research and one of the lead authors of the Cell paper.

Other lead authors of the paper are Koch Institute postdoc Thales Papagiannakopoulos and Broad Institute researchers Amaro Taylor-Weiner, Chip Stewart, and Scott Carter. Senior authors are Tyler Jacks, the David H. Koch Professor of Biology and director of the Koch Institute, and Gad Getz, director of cancer genome computational analysis at the Broad Institute and director of the bioinformatics program at Massachusetts General Hospital.

Tracking cancer progression

The research team
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy
2. Going viral to target tumors
3. Robert Avery, D.O., M.S.C.E., studies innovations to improve vision in children with tumors
4. Study reveals mechanisms cancer cells use to establish metastatic brain tumors
5. Cancer vaccine could use immune system to fight tumors
6. Tumors light up with new, unique imaging system using scorpion venom protein and a laser
7. Targeting tumors: Ion beam accelerators take aim at cancer
8. DNA-built nanostructures safely target, image cancer tumors
9. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
10. Neuro-Oncology Pioneer Who Defined Standard of Care for Brain and Spinal Tumors Joins Capital Institute for Neurosciences
11. Study finds that carbon monoxide can help shrink tumors and amplify effectiveness of chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Albuquerque, New Mexico (PRWEB) December 19, 2014 ... pain relief industry is excited to announce a new ... gauss rare earth magnets. These are the strongest neodymium ... therapy necklace. Pain Free Living developed the Superior Magnetics ... magnets. , “Pain Free Living performs magnetic therapy using ...
(Date:12/19/2014)... From November 24, 2014, Siddhi Yoga ... 2014 in its Goa retreat . This is the ... winters, from November to March, Siddhi Yoga will organize four ... Goa. The Goa training sessions will conclude in March 2015. ... training, the 10th intake is also a 200 YTT ...
(Date:12/19/2014)... After a 13-year absence from active touring, the ... stage to entertain his many worldwide fans. Trisha Yearwood ... successful tour has been steadily expanding since the very ... Ticketability.com for a large inventory of Garth Brooks ... , Music fans have had a long wait for ...
(Date:12/19/2014)... Consilium Staffing, Your Partner in Locum ... Federal Health Professionals annual meeting in Washington, D.C., ... and federal healthcare providers. , In addition, ... Engagement (NVSBE) conference last week in Atlanta, Georgia. ... solution in addressing our nation’s shortage of physicians,” ...
(Date:12/19/2014)... good shape seems to reduce your risk of high blood ... than 57,000 Americans, including more than 35,000 with high blood ... Those in the poorest shape had a more than 70 ... of the study, compared to a 50 percent chance for ... than 8,000 people diagnosed with high blood pressure during the ...
Breaking Medicine News(10 mins):Health News:New Superior Magnetic Necklace Relieves Migraine Headache 2Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 2Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 3Health News:Garth Brooks Tickets for Joe Louis Arena: Ticketability.com Becomes a Popular Destination for Discount Tickets for Garth Brooks’ Detroit Concerts Set for February 27-28 2Health News:Consilium Staffing Increasing Awareness of Locum Tenens through Conference Appearances 2Health News:Being Fit Keeps Blood Pressure in Check 2
... For many years, consumers have,been able to take out ... cosmetic surgeries, but they haven,t been able to borrow,money ... could save their,lives., As a result, many drug ... they need., The federal government is aware of ...
... May 14 An estimated 130,000 North,Carolinians suffer ... Easley and his wife Mary are joining the ... of,fibromyalgia during National Women,s Health Week. "It is ... diagnosis and treatment of,fibromyalgia as it often takes ...
... Duska Therapeutics,Inc. (OTC Bulletin Board: DSKA.OB) ... from the University of Pennsylvania,s Center for,Research ... the results of,the Company,s sponsored study showing ... and increases fertilizing,capability in mice., The ...
... Marcy Kaptur (D-Ohio) received the annual Joseph F. Boyle ... of Physicians (ACP) last night. The award is given ... an official capacity who has provided outstanding public service ... presenting the award to Rep. Kaptur, David L. Bronson, ...
... The latest information on the biology and treatment of testicular ... presented at the Symposium on Testicular Cancer organized by the ... 15-16 May in Munich, Germany. , "Testicular cancer is the ... and thirty-five and has seen the strongest increase in incidence ...
... /Xinhua-PRNewswire-FirstCall/ -- China Nepstar,Chain Drugstore Ltd. (NYSE: ... drugstore chain in China based on the number ... with the Shenzhen Charity,Federation to organize a program ... earthquake in Sichuan province, China. Specifically, the program ...
Cached Medicine News:Health News:A Better Tomorrow Becomes One of the First Rehabilitation Clinics in the Nation to Offer Financing for Its Drug, Alcohol and Gambling Treatment Programs 2Health News:Triangle Group Raises Awareness of Fibromyalgia 2Health News:Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals 2Health News:Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals 3Health News:Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals 4Health News:Ohio congresswoman cited by American College of Physicians 2Health News:Symposium focuses on curable cancer that affects young men 2Health News:China Nepstar Chain Drugstore Organizing An Earthquake Relief Program 2Health News:China Nepstar Chain Drugstore Organizing An Earthquake Relief Program 3
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, ... (CTMC), and Integrated Clinical Trial Services, LLC (ICTS), ... for clinical trials announce that they have formed ... Services (i-CTMS). i-CTMS will provide a broad range ... biotechnology and medical device companies. i-CTMS ...
(Date:12/15/2014)... 12, 2014 Research and Markets ( ... "Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram Devices ... 2016. The North America accounts ... while Europe claims approximately 27% ...
(Date:12/15/2014)... YORK and HERZLIYA PITUACH, Israel ... "Company") (NASDAQ: IMNP ) announced today that its ... the Board succeeding Dr. Daniel Teper who continues ... a member of Immune,s Board of Directors since 2013. ... "I am delighted to represent the interest of shareholders and ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4
... LAKE, N.J., Jan. 3, 2012  Arena Pharmaceuticals, Inc. (NASDAQ: ... has submitted its response to the Complete Response Letter (CRL) ... review of the lorcaserin New Drug Application (NDA). Lorcaserin is ... weight loss, in patients who are obese (Body Mass Index, ...
... Jan. 3, 2012 IDEXX Laboratories, Inc. (NASDAQ: ... 30 th Annual J.P. Morgan Healthcare Conference. Jonathan W. ... on the Company on Monday, January 9, 2012 at 2:30 ... California. Individuals can access the live audio webcast of the ...
Cached Medicine Technology:Arena Submits Response to FDA Complete Response Letter for Lorcaserin 2Arena Submits Response to FDA Complete Response Letter for Lorcaserin 3Arena Submits Response to FDA Complete Response Letter for Lorcaserin 4Arena Submits Response to FDA Complete Response Letter for Lorcaserin 5Arena Submits Response to FDA Complete Response Letter for Lorcaserin 6
Porous foundation 470 series....
The Opteon stem meets the challenge of providing a high-quality, cost-effective hip implant for the moderate demand patient....
Exactech's AcuMatch C-Series (cemented femoral stem) is designed to provide solutions to the problems which compromise both the short and long term successful outcome of cemented hip arthroplasty....
The link ribbed hip stem for cementless primary hip replacement surgery....
Medicine Products: