Navigation Links
New vaccine technology protects mice from hepatitis C virus
Date:2/23/2011

the inner genes, they will respond. Actually, the response is extremely potent, and one of the things it does is summon the specialised CD8 killer cells.

"We took a dead common cold virus, an adenovirus that is completely harmless and which many of us have met in childhood," Associate Professor Pravsgaard Christensen explains.

"We hid the gene for one of the HCV's internal molecules inside it. At the same time we attached a special molecule on the internal molecule so that when the cells of the mouse body tried to take a sample, they would extract a more extensive section. The immune defences would then be presented with a larger section of the molecule concerned. You may say that the immune defences were given an entire palm print of the internal genes instead of just a single fingerprint."

This strategy resulted in two discoveries from the team. Firstly, the mice were vaccinated for HCV in a way that meant that protection was independent of variations in the surface molecules of the virus. Secondly, the immune defences of the mice saw such an extensive section of the internal molecule that even though some aspects of it changed, there were still a couple of impressions the immune defences could recognise and respond to.

The new technology to be tested in monkeys

Another virus that mutates its surface molecules with extreme rapidity is HIV. It changes skin in the space of 24 hours, and like HCV, we do not yet have a cure or a vaccine. The researchers think that HIV originally migrated to man from monkeys in the 1930s, when it was the simian Immunodeficiency virus that still circulates among a number of species of wild African monkeys.

"The Danish Medical Research Council (DMRC) has given postdoc Peter Holst a grant to test our technology for a SIV vaccine for macaque monkeys in the US," says Associate Professor Pravsgaard Christensen.

The University of Copenhagen is also currently negotiating the
'/>"/>

Contact: Associate Professor Jan Pravsgaard Christensen
jpc@sund.ku.dk
453-058-9945
University of Copenhagen
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Supreme Court Rejects Vaccine-Safety Lawsuit
2. MIT engineers design new nanoparticle that could lead to vaccines for HIV, malaria, other diseases
3. Efficacy of tuberculosis vaccine enhanced
4. Universal flu vaccine study yields success in mice
5. International Vaccine Institute announces launch of Dengue Vaccine Initiative
6. Universal Flu Vaccine Shows Promise in Early Trial
7. HPV vaccine works for boys: Study shows first clear benefits
8. H1N1 Flu Vaccine Very Effective: Study
9. Last Years H1N1 Flu Vaccine Was Safe, Study Finds
10. Gardasil Vaccine Guards Against HPV in Boys
11. New study identifies potential vaccine to prevent gastritis, ulcer disease, gastric cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... David Cooke presented two scientific posters ... looked at the clinical benefits of MPI gated studies ... function. In conjunction with colleagues at Emory University, Cooke ... LVEF by echo (>50%). Each patient had same-day 99mTc ... Emory Toolbox 4.0 was used to analyze ...
(Date:9/20/2014)... Baja, Mexico (PRWEB) September 20, 2014 ... announced the resort did not experience any damage in ... all amenities and activities available. , Hurricane Odile struck ... bringing intense wind, rain and powerful surf conditions. Located ... del Palmar Islands of Loreto experienced some heavy rain, ...
(Date:9/20/2014)... Ticket Down is a dependable ... This popular ticket exchange is offering their customer appreciation promo ... schedule of tours is beginning to fill up. Many of ... to hit the road, including 21-year-old pop superstar, Ariana Grande. ... Tour,” which will take her to 25 cities across the ...
(Date:9/20/2014)... 20, 2014 On Monday, September 22, ... pediatric cancer research grant from Hyundai Hope on Wheels ... Children’s Hospital located on 11234 Anderson St., in Loma ... Kimberley Payne, Associate Professor at Loma Linda University and ... leukemia in children. , Loma Linda University ...
(Date:9/20/2014)... The print component of “Work-Life ... the Calgary Herald, with a circulation of approximately ... The digital component is distributed nationally through a ... of top news sites and partner outlets. To ... http://www.worklifebalanceinfo.ca . , The publication features an ...
Breaking Medicine News(10 mins):Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 3Health News:Villa del Palmar at the Islands of Loreto Fully Functioning After Hurricane 2Health News:Villa del Palmar at the Islands of Loreto Fully Functioning After Hurricane 3Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 2Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 3Health News:Loma Linda University Medical Center Receives $250,000 Research Grant From Hyundai Hope On Wheels In Honor Of National Childhood Cancer Awareness Month 2Health News:Loma Linda University Medical Center Receives $250,000 Research Grant From Hyundai Hope On Wheels In Honor Of National Childhood Cancer Awareness Month 3Health News:Getting ‘Wellthy’: Mediaplanet’s “Work-Life Wellness” campaign puts stock in the personal and economic gains of healthy, vital workplace environments for Canadians 2
... go for the veggies , , WEDNESDAY, March 19 (HealthDay News) ... decidedly the carnivores while women prefer leaner, greener fare, a ... play a role, but "more obvious are cultural influences, which ... manly," according to Dr. David L. Katz, director of the ...
... The eighth annual American,Transplant Congress 2008 (ATC) ... field of basic and clinical transplantation,science and medicine. ... Canadian transplant and fittingly, the meeting travels to ... Centre in Toronto,Ontario hosts ATC 2008 from Saturday, ...
... PHILADELPHIA Researchers at the University of Pennsylvania School ... detailed look at the molecular pathways underlying sleep apnea, ... the National Institutes of Health. Sleep apnea is a ... which disruptions can occur dozens or even hundreds of ...
... of Surveyed Physicians Anticipate an Increase in the, Number of ... 19 Percent of Surveyed MCOs Will Not Add Novel ... According to a New Report ... Resources, one of the,world,s leading research and advisory firms for ...
... in Comprehensive Report Comparing SSO and ... Healthcare Industry, ANDOVER, Mass., March 19 ... Sign-On (SSO), announced today that it ranked ... comparing SSO and,context management vendors performance. The ...
... Eight out of 10,Americans are concerned about access ... cuts to physicians caring for Medicare patients,according to a ... (AMA). On July 1, Medicare payments to physicians will ... cuts will grow to about 40,percent while medical practice ...
Cached Medicine News:Health News:The Gender Divide Starts Over Dinner 2Health News:The Gender Divide Starts Over Dinner 3Health News:American Transplant Congress 2008 - Critical New Data to be Revealed in Toronto 2Health News:Molecular biology of sleep apnea could lead to new treatments 2Health News:One-Third of U.S. Primary Care Physicians and Cardiologists Do Not Currently Prescribe Treatment to Meet HDL Cholesterol Targets as Recommended By National Guidelines 2Health News:One-Third of U.S. Primary Care Physicians and Cardiologists Do Not Currently Prescribe Treatment to Meet HDL Cholesterol Targets as Recommended By National Guidelines 3Health News:Sentillion Ranked #1 Vendor in KLAS' Single Sign-On & Context Management Report 2Health News:Sentillion Ranked #1 Vendor in KLAS' Single Sign-On & Context Management Report 3Health News:New Poll Shows Public Worried About Medicare Cuts Impact on Seniors, Boomers - Wants Congress To Act 2
(Date:9/19/2014)... 19, 2014 Today, iHealth Lab Inc. announced it ... Ltd. for its first institutional round of funding. The ... global reach, accelerate growth and innovation, and invest in ... investment, Xiaomi Ventures will join iHealth,s board of directors, ... and ecommerce. "We are very pleased to ...
(Date:9/19/2014)... Kiromic, LLC, a Lubbock bio-pharmaceutical company, ... former chancellor of Texas Tech University, to its board as ... after raising $1.2 billion for the university. "Kiromic ... most successful chancellor in the history of Texas Tech University, ... but also as our new vice chairman of the board. ...
(Date:9/19/2014)... , Sept. 19, 2014  For Cloud ... drug design and development, partnering is an integral ... is to design new drugs and identify early ... partners to further their development. The company also ... To support this business model, Cloud Pharmaceuticals will ...
Breaking Medicine Technology:iHealth Raises $25 Million to Fuel Growth and Global Market Share 2Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2
... Knee Brace uses muscle power to place ... MA) directed force against the knee during ... mild to moderate symptomatic lateral or medial ... Bledsoe has engineered the Thruster 2.,Indications,Aligner LA ...
... The Bledsoe Sport & Sport Max patellofemoral ... meniscal and/or collateral injuries. Patients with minor ... damage can benefit from added support to ... brace designs to provide the right kind ...
... The Bledsoe Original Knee Brace gives ... For positive ROM control, this brace features ... extension and flexion from 0-120, and positively ... Designed with two eccentric cam slots, the ...
... Bledsoe Revolution Knee Brace ... fitting under post-op conditions. ... surgeon or authorized technician ... fitting and application that ...
Medicine Products: