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New vaccine candidate shows strong potential to prevent highly contagious norovirus
Date:3/15/2011

virus-like particles should function," Li said. "The virus-like particles can be continually produced in animals or humans for several weeks and stimulate strong immune responses. That's the advantage of using VSV."

Li said the VSV-based recombinant is also considered a powerful application because it can essentially be used as a bioreactor to facilitate large-scale production of these specific virus-like particles. In addition, it saves time: The viral vector developed virus-like particles within two days.

For comparison purposes in this study, Li and Ma also created a more traditional vaccine candidate by inserting a human norovirus gene into a different type of virus: a baculovirus, which is rod-shaped. It took six days for these viruses to grow enough to be used as a vaccine candidate, and the production level was comparatively low.

The scientists then conducted an animal study to observe what kind of immune response the VSV-based norovirus vaccine candidate could generate. Mice received either the VSV-based vaccine or various types of control substances for comparison, including one group that received the vaccine created with the more traditional technique. The substances were given orally or through the nose.

Weekly blood samples showed that two weeks after receiving the vaccines, the mice given the VSV-based norovirus vaccine had developed and sustained a high level of antibodies against the human norovirus about 25 times higher levels of antibodies than those induced by the traditionally prepared vaccine candidate.

"This might be the most important advantage of the VSV-based norovirus vaccine candidate: It prepares a high concentration of norovirus-specific antibodies that can assist with virus detection, disease diagnosis and therapy," Li said.

In addition, the mice vaccinated with VSV-based vaccine generated a T cell immune response that was two times higher than the T cell response produced in mi
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Contact: Jianrong Li
li.926@osu.edu
614-688-5728
Ohio State University
Source:Eurekalert

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