Navigation Links
New upper limit defined for normal ALT in adolescent males
Date:12/3/2007

A new cohort study of adolescent offenders in Australia has identified an upper limit for ALT that is more sensitive for the diagnosis of liver disease. The findings could facilitate targeted interventions for the youths in this group, who are at high risk for HCV infection and obesity-related liver disease. The study is in the December issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (http://www.interscience.wiley.com/journal/hepatology).

Few studies have examined the liver health of at-risk adolescents, or reported associations between liver biochemistry and hepatitis C virus or metabolic liver disease. Researchers Dr David van der Poorten and Professors Dianna Kenny and Jacob George of Sydney University, analyzed data from a large cohort of young male offenders under supervision by the New South Wales Department of Juvenile Justice in Australia, who took part in a comprehensive health study, funded by the Australian Research Council, NSW Department of Juvenile Justice and Justice Health. The researchers sought to create a new definition for the normal upper limit of liver biochemistry; to define the associations and implications of raised ALT; and to understand the risk factors and associations with hepatitis C.

They examined the results of liver tests and lipid studies from blood samples of 439 young male offenders serving community orders who agreed to participate in the health survey between October 2003 and December 2005. They also considered clinical, demographic, and lifestyle data and performed statistical analyses to determine relevant associations.

They determined the upper limit of normal for liver enzymes using the liver tests of the participants at lowest risk of liver disease. These young men had normal BMI, cholesterol, triglycerides, and blood pressure; and did not have hepatitis B or C infection, or high alcohol consumption. The researchers determined that the upper limit of normal was 28 IU/L for ALT; 32 IU/L for AST; and 29 IU/L for GGT. These are significantly lower than current upper limits for these tests which usually range from 45-55 IU/L.

Applying these cutoffs to all participants, they found that 17 percent had raised ALT, and compared to those with normal ALT, there was a strong association for overweight or obesity, the authors report. To prevent further hepatic damage and to minimize cardiovascular and diabetes risk, targeted interventions in adolescents at the earliest stages of metabolic dysfunction are a particularly high priority.

The new upper limits also detected 80 percent of the HCV-infected patients, who were significantly more likely to have injected drugs in the last 12 months. A one-year follow-up blood test of 81 of the original participants showed additional incidents of HCV antibodies, suggesting a new infection rate of at least 3.7 percent per year.

The results indicate a concerning level of HCV exposure among this population. Hence, greater education regarding blood borne viruses, risk factors for transmission and implementing harm minimization strategies in this population is crucial, the authors write. They also suggest routine hepatitis B vaccination.

In conclusion, they write, this study has provided a wealth of clinical and health related data relevant to adolescents. The new definition of normal adolescent ALT allows greater sensitivity in diagnosing early liver disease. By identifying those with hepatitis B, C and obesity related liver disease; targeted interventions can and should be implemented to minimize future health-related morbidity.


'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Fat on chest and upper back increases risk of insulin resistance
2. Patients may have sweet and effective way to prepare for upper GI endoscopy: an anesthetic lollipop
3. Supratek Pharma Inc. announced today that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for SP1049C for the treatment of metastatic adenocarcinoma of the upper gastrointestinal tract
4. Don Messer Will Speak in Upper Room Chapel to Observe World AIDS Day
5. Prominent Orthopaedic Hand and Upper Extremity Surgeon Joins Radlink Board of Directors
6. GERD Not Limited to Grownups
7. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
8. Limiting Residents Hours Has Little Impact on Patient Mortality
9. Study finds limiting work hours for surgical residents enhances training
10. Severe heart attack damage limited by hydrogen sulfide
11. Limiting refined carbohydrates may stall AMD progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
Breaking Medicine Technology: