Navigation Links
New universal platform for cancer immunotherapy developed by Penn-led team
Date:3/5/2012

tained in the universal immune receptor. Since nearly any molecule can be biotin labeled, the number of antigens that can be targeted by T cells carrying the biotin-binding immune receptor is nearly infinite. The versatility afforded by this biotin-binding receptor permitted the targeting of a combination of distinct antigens all at once, and even one after another, notes Powell.

The findings demonstrate that a universal T cell can significantly extend conventional CAR approaches, allowing the team to generate T cells of unlimited antigen specificity. This process is geared to make T cell therapy more available to patients and to improve the effectiveness of T-cell immunotherapies for cancer.

First author post-doctoral fellow Katarzyna Urbanska, Ph.D. continues optimization of the universal receptor approach by looking for different ways to improve the interaction of T cells with tumor cells, and how to better direct the T cells and the biotin-labeled molecules to tumor cells in the body.

In the future, Powell and colleagues predict a highly personalized platform for cancer therapy that begins when patient tumors are analyzed for their expression of specific antigens at the Department Pathology and Laboratory Medicine's new Center for Personalized Diagnostics. When the antigens expressed by a patient's tumor cells are determined, their T cells will be engineered to express the universal immune receptor, which will be given back to them in combination with biotin-labeled molecules to attach to patients' tumor antigens for an individualized tumor attack.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study finds shifting disease burden following universal Hib vaccination
2. Researchers Closer to Developing Universal Meningitis B Vaccine
3. Universal flu vaccine clinical trials show promise
4. Brazils health care system vastly expands coverage, but universality, equity remain elusive
5. Universal screening programs can uncover abuse, study finds
6. Internists remind physicians about universal ethical principles
7. Universal flu vaccine study yields success in mice
8. Universal Flu Vaccine Shows Promise in Early Trial
9. Pandemic flu strain could point way to universal vaccine
10. Universal standards proposed for prescription container labels to help reduce medication misuse
11. World Health Report 2010 balanced but incomplete account of how to achieve universal health coverage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New universal platform for cancer immunotherapy developed by Penn-led team
(Date:7/11/2014)... Even the hot Texas sun won’t keep ... . The school had previously invested in a ... from APCPLAY, but recently asked for an innovative solution to ... Godley Elementary School chose a Rectangular Shade from APCPLAY as ... on their playground. The shade measures 24’W x 34’H ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Based in ... care to residents of Brazoria County and surrounding counties. ... the clinic is now accessible from Northbound Highway 288 ... a center where patients can get low-cost urgent care ... far from rare, finding places that can match the ...
(Date:7/10/2014)... 2014 Fatigue, lack of safety ... number of accidents in the workplace, according to ... articles highlight safety issues that contribute to the ... occur on the job annually, according to the ... explore "preventable workplace accidents." , Safety Issue: "Extended ...
(Date:7/10/2014)... 2014 According to a new ... Platforms (Land, Airborne, Naval), Application (Software Defined Radios, ... Geography (North America, Asia-Pacific, Europe, the Middle East ... by MarketsandMarkets, the market is estimated to be ... register a CAGR of 5.56% to reach $39.52 ...
(Date:7/10/2014)... 2014 Parker Waichman LLP, a ... of victims injured by defective medical devices, reports ... allegations that the woman’s hidden, aggressive leiomyosarcoma was ... used during a routine laparoscopic supracervical hysterectomy procedure. ... Medical Instruments Corporation over its Wolf Power Morcellator ...
Breaking Medicine News(10 mins):Health News:Cool Fun Under the Texas Sun: Godley Elementary School Purchases Shade Structure from APCPLAY© 2Health News:Prime Urgent Care Announces New Access to the Clinic, Available from Northbound Highway 288 2Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 2Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 2Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 3Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 5
... , This release is available in Spanish ... have a powerful effect on formation of strong, healthy bones, ... hold true for humans. Jin-Ran Chen and his ... U.S. Department of Agriculture (USDA) at the Arkansas Children,s Nutrition ...
... tsunamis to war and genocide which wreak devastation on millions ... from the headlines. But how do policymakers, charities and medics ... influences their tactics and the style of humanitarian aid? ... London School of Hygiene & Tropical Medicine, with Boris Martin, ...
... In the 1983 movie "A Man with Two Brains," Steve Martin ... two brains inside his own skull as we all do, ... it comes to seeing the world around us, each of our ... working memory. Normally, it takes years or decades after a ...
... By Steven Reinberg HealthDay Reporter , MONDAY, ... increasingly popular, inflatable models, pose serious risks to young children, ... Children,s Hospital in Columbus, Ohio, detail the drowning deaths of ... a variety of above-ground pools, some large and deep, others ...
... substitutes used in low-calorie potato chips and other foods ... according to a study published by the American Psychological ... challenges the conventional wisdom that foods made with fat ... fat substitutes can interfere with the body,s ability to ...
... of medicine and community health sciences at Boston University ... Institute on Drug Abuse (NIDA) International Program 2011 Awards ... and investment in mentoring scientists in their pursuits in ... who is also chief of the Section of General ...
Cached Medicine News:Health News:Blueberries help lab rats build strong bones 2Health News:New book shines light on French versus British models of humanitarian aid 2Health News:Picower: 1 skull + 2 brains = 4 objects in mind 2Health News:Picower: 1 skull + 2 brains = 4 objects in mind 3Health News:Portable Pools Pose Drowning Risk for Young Kids 2Health News:Portable Pools Pose Drowning Risk for Young Kids 3Health News:Fat substitutes linked to weight gain 2Health News:BU'S Jeffrey H. Samet, M.D., selected as a 2011 NIDA International Program Awards of Excellence winner 2
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... its store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ... upgrade and policy support, China,s ... years, with total market size rising from 3.28 billion ...
(Date:1/15/2014)... Jan. 15, 2014  Novation, the leading health care supply ... IT value-added reseller (VAR) national contracts that expand its ... services at lower costs. These include manufacturer product and ... initiative assistance and ongoing IT consulting support. ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... April 9, 2008 Dutch biotechnology,company Crucell N.V., ... South,African Tuberculosis Vaccine Initiative (SATVI) present a progress ... tuberculosis vaccine study at the,biennial "Tuberculosis Vaccines for ... today. The study, conducted in Worcester, South,Africa and ...
... NEW YORK, April 9, 2008 Intra-Cellular ... its ongoing development,programs for ITI-007, the Company,s ... (DPPM), and ITI-722,a low-dose formulation of ITI-007, ... disorders, respectively. These new data demonstrate,ITI-007 has ...
Cached Medicine Technology:Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 2Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 3Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 4Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 5Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 6Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722 2Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: