Navigation Links
New universal platform for cancer immunotherapy developed by Penn-led team
Date:3/5/2012

tibody onto an immune cell. This allows the patients' T cells to recognize tumor antigens and kill their tumor cells.

For therapy, a large number of tumor-specific, cancer-fighting CAR T cells can be generated in a specialized lab using patients' own T cells, which are then infused back into them. This approach has shown promising results in patients whose tumors all express the same antigen.

Despite these encouraging findings, currently made CARs have a fixed antigen specificity, which means only one type of tumor antigen can be targeted at a time. Tumor cells that lack that selected antigen can then escape recognition by immune cells and replicate, limiting what might otherwise have been an effective therapy if multiple tumor antigens had been targeted. For this reason, the team sought to make a more generalized receptor framework that is able to produce T cells capable of targeting large panels of known tumor antigens.

To that end, the team developed a new platform from which they could eventually target a variety of tumor antigens, either simultaneously or sequentially. So far, they have engineered T cells against the antigens mesothelin, present on several tumor cell types; epCAM, present on epithelial cell cancers; alpha folate, present on ovarian cancer cells; and, more recently, CD19 on lymphoma cells.

The universal immune receptor recognizes molecules attached to tumor antigens on the surface of tumor cells. When this happens, the T cells produce inflammatory response proteins called cytokines and pore-forming proteins. Those proteins cause the release of enzymes through those pores into tumor cells, thereby killing them.

The new engineered T cells described in the Cancer Research paper recognize and bind exclusively to cancer cells pre-targeted with biotin-labeled molecules, such as antibodies. Biotin is a B complex vitamin necessary for cell growth that can be bound by a molecule called avidin, which is con
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Study finds shifting disease burden following universal Hib vaccination
2. Researchers Closer to Developing Universal Meningitis B Vaccine
3. Universal flu vaccine clinical trials show promise
4. Brazils health care system vastly expands coverage, but universality, equity remain elusive
5. Universal screening programs can uncover abuse, study finds
6. Internists remind physicians about universal ethical principles
7. Universal flu vaccine study yields success in mice
8. Universal Flu Vaccine Shows Promise in Early Trial
9. Pandemic flu strain could point way to universal vaccine
10. Universal standards proposed for prescription container labels to help reduce medication misuse
11. World Health Report 2010 balanced but incomplete account of how to achieve universal health coverage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New universal platform for cancer immunotherapy developed by Penn-led team
(Date:5/24/2013)... May 24, 2013 Western University of ... status of “Full Accreditation” for the next seven years ... Education (COE). , “This is a magnificent achievement, and ... work and student outcomes,” said College of Veterinary Medicine ... my appreciation to the faculty, staff, preceptors, and students ...
(Date:5/24/2013)... 2013 The Mirena IUD lawyers ... that the FDA has received more than 59,229 complaints since ... the intrauterine birth control device known as the Mirena IUD.* ... reported by the women “included ‘expulsion,’ where the IUD came ... occurring,” according to an ABC News article. “Abdominal pain is ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Gift ... Cards, major competitors in sustainable card material, are ... using forest materials as a sustainable gift card ... to identify industry challenges and increase education and ... programs to support the reduction of carbon footprint ...
(Date:5/24/2013)... of highly respected Alzheimer,s researchers failed to replicate what ... this brain disease when they were published last year ... presented online Feb. 9, 2012, suggested that the drug ... of beta amyloid plaques (Aβ) a pathological hallmark ... According to the authors of the 2012 report, drug ...
(Date:5/24/2013)... Mr. Brian Su, CEO of Artisan ... Investment Summit: Dealmakers Conference in Long Beach, California on ... exploring alternative finance through EB-5 immigrant investors program. The ... information, and updates to project developers, regional center executives, ... , "Our goal is to assist EB-5 projects in ...
Breaking Medicine News(10 mins):Health News:Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 3Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3Health News:Brian Su Organizes 3rd Annual EB-5 Investment Conference in Long Beach, California 2
... PAUL, Minn., Dec. 1 Acuo Technologies(R), developers,of ... tools and services, today announced the contracting with ... for a new vendor neutral archiving,solution which becomes ... The archiving solution is based on the ...
... recognition of World AIDS Day, Charlotte Bobcats, Emeka Okafor, will be ... Million African Lives Initiative (OMALI), a program of the Safe Blood ... to save one million lives in Africa by 2011 by working ... , , OMALI will be collecting ...
... MONICA, Calif., Dec. 1 TOMS Shoes, the philanthropic,footwear ... people to Spend Less and Give More this holiday ... TOMS is asking holiday,shoppers to help give 30,000 pairs ... disease that is 100% preventable by wearing shoes. By,purchasing ...
... include economical options , , , ... a new pair of pajamas or a video game are all quick ... But this year, why not give something more healthy and beneficial to ... , Staying healthy around the holidays can ...
... 1 TorreyPines Therapeutics, Inc.,(Nasdaq: ... of NGX426, an,AMPA/kainate-type glutamate receptor antagonist, demonstrated ... (abnormally increased,pain state) and allodynia (pain resulting ... to placebo following intradermal injections of capsaicin ...
... as Vice President of Preclinical Sciences and Marie Green, ... , CAMBRIDGE, Mass., Dec. 1 ... team with the appointment of Jeffrey T. Walsh as ... additions of Christopher Horvath, D.V.M., as vice president of ...
Cached Medicine News:Health News:Acuo Technologies Announces Vendor Neutral Archiving Contract With Rush University Medical Center 2Health News:Acuo Technologies Announces Vendor Neutral Archiving Contract With Rush University Medical Center 3Health News:In Recognition of WORLD AIDS DAY, Charlotte Bobcats' Power Forward, Emeka Okafor, Launches Mobile Texting Campaign in Support of the One Million African Lives Initiative 2Health News:TOMS Shoes Embarks on a Holiday Mission: Give 30,000 Pairs in 30 Days! 2Health News:Giving the Gift of Health This Holiday Season 2Health News:Giving the Gift of Health This Holiday Season 3Health News:Giving the Gift of Health This Holiday Season 4Health News:TorreyPines' NGX426, an Oral AMPA/Kainate Receptor Antagonist, Meets Primary Endpoints in Reducing Capsaicin-Induced Pain in Healthy Subjects 2Health News:TorreyPines' NGX426, an Oral AMPA/Kainate Receptor Antagonist, Meets Primary Endpoints in Reducing Capsaicin-Induced Pain in Healthy Subjects 3Health News:TorreyPines' NGX426, an Oral AMPA/Kainate Receptor Antagonist, Meets Primary Endpoints in Reducing Capsaicin-Induced Pain in Healthy Subjects 4Health News:TorreyPines' NGX426, an Oral AMPA/Kainate Receptor Antagonist, Meets Primary Endpoints in Reducing Capsaicin-Induced Pain in Healthy Subjects 5Health News:Taligen Therapeutics Advances Corporate Growth Plan with Appointment of Jeffrey T. Walsh as Chief Business Officer 2Health News:Taligen Therapeutics Advances Corporate Growth Plan with Appointment of Jeffrey T. Walsh as Chief Business Officer 3
(Date:5/23/2013)... 23, 2013 Hearing health affects a man,s lifestyle, ... remain socially and professionally engaged, he should address any hearing ... that the Better Hearing Institute (BHI) is delivering ... Men,s Health Week , which leads up to and includes ... June 10 through June 16. To help ...
(Date:5/23/2013)... More than half of women diagnosed with ... and still have excellent outcomes. To educate women, Agendia, ... largest sources of online consumer information about breast cancer ... provide recently diagnosed women with information sources, to help ... "We anticipate these innovative social media campaigns will ...
(Date:5/23/2013)... , May 23, 2013  Hologic, Inc. ... ), a leading developer, manufacturer and supplier of ... with an emphasis on serving the healthcare needs ... observational study in a U.S. clinical practice comparing ... (breast tomosynthesis) with conventional 2D mammography alone showed ...
Breaking Medicine Technology:Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 2Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... CLARA, Calif. and TEL AVIV, Israel, May 22, ... focused on delivering mixed-signal semiconductors, modules and subsystems ... that it has signed a distribution agreement with ... and distributor, will be a key partner driving ...
... 2012  Today ZocDoc introduces its service ... access to appointments with Greater Denver,s leading doctors, ... launch, this free service provides patients with their ... primary care doctors, obstetrician-gynecologists, dermatologists and eye doctors ...
Cached Medicine Technology:Cephasonics Inks Distribution Deal With Tritech To Extend Worldwide Sales Reach Into Israel 2Denver Patients Can Now Easily Find Doctors and Schedule Appointments Online 2Denver Patients Can Now Easily Find Doctors and Schedule Appointments Online 3Denver Patients Can Now Easily Find Doctors and Schedule Appointments Online 4
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Medicine Products: